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Press Releases from Hunan Huateng Pharmaceutical Co. Ltd. (26 total)

Huateng Pharma Develops Intermediates of Semaglutide For TD2

According to the latest IDF Diabetes map, the global prevalence of diabetes reached 10.5% in 2021, with 537 million adults living with diabetes. China has become a disaster zone for diabetes, with the largest number of adults with diabetes in the world. In the past 10 years (2011-2021), the number of people with diabetes in China increased from 90 million to 140 million, an increase of 56%. The total number

The Future of Treatment For Type 2 Diabetes

Although the treatment of type 2 diabetes (T2DM) has made impressive progress in the past few decades, researchers are constantly searching for new treatments. How to better control blood glucose and reduce diabetes-related complications has become a hot topic in the field of T2DM research. Previously, The Lancet Diabetes Endocrinology published an in-depth review detailing novel therapeutic targets for T2DM, mechanisms of drug action, and corresponding hypoglycemic efficacy. It involves innovation

Huateng Pharma Supplies PEG Products As Ingredients In mRNA COVID-19 Vaccines

Since the COVID-19 epidemic, Pfizer and Moderna have used mRNA technology in a vaccine to help humans fight COVID-19. While mRNA technology is new to the public, the research has been around since the early 1990s. What is an mRNA vaccine? An mRNA vaccine is a vaccine that uses a molecular copy of messenger RNA (mRNA) to generate an immune response. Such vaccines deliver mRNA molecules into the body's immune cells, where

A Review of Therapies For Alzheimer's Disease

Alzheimer's disease (AD) is a progressive, irreversible neurodegenerative disease clinically manifested by cognitive impairment, behavioral abnormalities, and social deficits. It is predicted that by 2050, the number of people 65 and older with dementia in the United States could reach 13.8 million. In China, more than 15.07 million elderly people aged 60 or over suffer from dementia, of which about 9.83 million suffer from AD. At present, the pathogenesis of AD

Huateng Pharma Supplies Intermeidates of Pemetrexed Against NSCLC

Pemetrexed disodium is a drug successfully developed by Eli Lilly in the United States for the treatment of tumors, patent protection to January 2017. Pemetrexed disodium is a multi-targeted anti-folate agent with a core pyrrolopyrimidine moiety in its structure. It is a dual inhibitor of nucleotide synthase/dihydrofolate reductase, which inhibits cell replication by disrupting the normal process of folate-dependent metabolism in cells and simultaneously blocking three different enzyme targets critical

Huateng Pharma Supplies Canagliflozin Intermediates With Commercial Scale Produc …

Canagliflozin is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. Mechanism action of Canagliflozin Canagliflozin is a sodium-glucose cotransporter (SGLT2) inhibitor. Glucose filtered in the renal tubular lumen is mainly reabsorbed by SGLT2 expressed in the proximal renal

Huateng Pharma Supplies Ensitrelvir Intermeidates Against COVID-19

Ensitrelvir (code name S-217622, brand name Xocova), is a new inhibitor of the SARS-CoV-2 major protease (Mpro), also known as 3C-like protease, has been shown to reduce the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters. In cells, low nanomolar to sub-micromolar doses of Ensitrelvir suppress viral growth. In hamsters, oral treatment of Ensitrelvir showed excellent pharmacokinetic qualities and hastened recovery from acute SARS-CoV-2 infection. Ensitrelvir

Huateng Pharma Develops Caronic Anhydride & Derivatives As Paxlovid Intermediate …

On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM). This NEJM article published viral load data that Paxlovid reduced viral load by 0.868 log10 compared to controls for 5 days of treatment, which equates to a remarkable 7.38-fold reduction in viral load. This pivotal study (NCT04960202) enrolled 2,246 patients with COVID-19, 1,120 received

The Basic Information About Orlistat

According to statistics from the World Health Organization (WHO), nearly 2 billion people are overweight or obese worldwide. Every year, overweight or obesity causes 2.8 million deaths. What 's Orlistat ? Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes. It was originally approved by the FDA in 1999 as the prescription drug Exenical, was approved in 2007 as the over-the-counter

Eating Fruit Every Day Can Reduce The Risk of Developing Type 2 Diabetes

Eating at least two serves of fruit daily has been linked with 36 percent lower odds of developing type 2 diabetes, a new Edith Cowan University (ECU) study has found. The study, published today in the Journal of Clinical Endocrinology and Metabolism, revealed that people who ate at least two serves of fruit per day had higher measures of insulin sensitivity than those who ate less than half a serve. Type 2

Is There A Link Between COVID-19 And Parkinson's Disease

Case reports of younger COVID-19 patients developing Parkinson’s disease within weeks of contracting the virus led researchers to investigate a possible link between the two conditions. Scientists recently demonstrated that, in the test tube, the SARS-CoV-2 N-protein interacts with a neuronal protein known as α-synuclein and boosts the development of amyloid fibrils—the pathological protein bundles characteristic of Parkinson’s disease. Along with causing respiratory symptoms, SARS-CoV-2 can induce neurological problems, like headaches,

Dolutegravir is a first-line treatment for newly diagnosed HIV patients

A new study by UBC researchers is set to change international treatment recommendations for people who are newly diagnosed with HIV--an update that could affect nearly two million people per year worldwide. The study found that dolutegravir is the optimal medication for first-line treatment for people newly diagnosed with HIV, a choice that has not been clear over the past several years. Dolutegravir (DTG), sold under the brand name Tivicay, is

Vitamin D May Prevent Severe COVID-19 Disease And Death

New research from Trinity College and University of Edinburgh has examined the association between vitamin D and COVID-19, and found that ambient ultraviolet B (UVB) radiation (which is key for vitamin D production in the skin) at an individual's place of residence in the weeks before COVID-19 infection, was strongly protective against severe disease and death. Previous studies have linked vitamin D deficiency with an increased susceptibility to viral and bacterial respiratory

Existing Drugs May Inhibit SARS-CoV-2 Virus

The COVID-19 pandemic has caused more than 600,000 deaths in the United States since the start of 2020 and more than 4 million globally. The search for effective treatments against the disease are ongoing, and one hurdle is that SARS-CoV-2, the virus that causes COVID-19, has a number of tricks up its molecular sleeve when it comes to infecting people. In a recent study published in Nature Communications Biology, researchers from

Disguised Protein May Be A New Target For Cancer Immunotherapy

Researchers at the Francis Crick Institute have identified a protein that helps tumors evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments. A crucial part of the immune system's response to cancer is a group of white blood cells, called CD8+ T-cells, which kill tumor cells. Before they launch their anti-tumor response,

Lipid Nanoparticles, Key Component of COVID-19 mRNA Vaccines

Lipid nanoparticles have been developed as vehicles for small molecule delivery by the nanomedicine and materials communities and are now a key component of COVID-19 mRNA vaccines. Vaccines against COVID-19 have been developed with unprecedented speed. In particular, mRNA vaccines — a technology already in clinical trials for other infectious diseases, such as influenza — have shown impressive efficacy in clinical trials.  mRNA vaccines rely on the delivery of mRNA into the

Most People Are Susceptible To Type 2 Diabetes

A recent study from scientists at Indiana University School of Medicine, the University of Michigan and Case Western Reserve University has determined that the sequence of insulin has become entrenched at the edge of impaired production, an intrinsic vulnerability unmasked by rare mutations in the insulin gene causing diabetes in childhood. The study exploits biophysical concepts and methods to relate protein chemistry to the emerging field of evolutionary medicine. Insulin is

Potential of Anti-influenza Drugs For The Control of High Pathogenicity Avian In …

Scientists have discovered a route of introduction for High Pathogenicity Avian Influenza Virus (HPAIV) H5N8 into Japan and, in parallel, have investigated the potential of two human anti-influenza drugs for the control of HPAI in birds. Since October 30, 2020, there have been over 30 recorded outbreaks of High Pathogenicity Avian Influenza (HPAI) in domestic poultry and wild fowl in Japan. This outbreak was caused by the influenza A virus H5N8,

The Relationship Between Vitamin D Deficiency And Type 1 Diabetes

Genetically determined vitamin D levels do not have a large effect on risk of type 1 diabetes in Europeans, according to a study published 25th February 2021 in the open-access journal PLOS Medicine by Despoina Manousaki from the CHU Sainte Justine and the University of Montreal, Canada and colleagues. Type 1 diabetes, once known as juvenile diabetes or insulin-dependent diabetes, is a chronic disease in which the pancreas produces little or no insulin. Type 1

New Drug Combination Could Control Blood Sugar And Weight In Diabetes

Scientists have shown that adding an experimental cancer drug to a widely used diabetes treatment improves blood sugar control and weight loss in mice, according to a study published on 22nd, Dec. in eLife. The results pave the way for clinical studies of the new drug combination as a more effective long-term treatment for millions of people with diabetes and obesity. Glucagon-like peptide 1 agonists (GLP-1 analogs) are a relatively new class of

New Therapy For Lung Cancer And Related Secondary Tumors

In 20 - 40% of patients with cancer, metastasis (the development of secondary tumors) in the central nervous system (CNS) occurs. CNS metastatis impacts negatively on a patient's quality of life, and is associated with a poor health prognosis. In a form of cancer known as ALK-rearranged non-small-cell lung cancer (NSCLC), CNS metastasis is known to persist when drugs targeting primary tumors are used. Now, Seiji Yano from Kanazawa University

A New Antiviral Strategy Was Discovered For Treating COVID-19

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19. They discovered that a class of metallodrugs currently used in the treatment

Professional Pharmaceutical Intermediates Supplier Huateng Pharma Has Its Own Fa …

Hunan Huateng Pharmaceutical Co., Ltd. is a leading and professional manufacturer which can provide PEG derivatives, biochemical reagents, pharmaceutical intermediates, APIs, Vitamin D Derivatives and targeted anti-tumor drugs. Today, Huateng Pharma has an R&D base of 5,000 square meters and a smart pharmaceutical industrial park with an investment of RMB 300 million and an industrial park of 34,000 square meters that has been completed and will be put into operation soon.

Safety And Effectiveness Of First-line Antihypertensive Drug Classes

For those with extremely high blood pressure, or hypertension, there are many initial medication options -- so many that it can be hard to know which one to use. Now, a Yale-coauthored paper in Lancet provides more information about the relative safety and effectiveness of different hypertension drugs in order to inform this critical treatment decision. The study reveals that angiotensin converting enzyme (ACE) inhibitors may not be the best

A Flu Drug Baloxavir Marboxil Can Reduce Spread Within Households

A single dose of the flu drug baloxavir marboxil can reduce the spread of the illness within households, new research concludes. A study examining 752 household contacts of 545 patients with the flu found that flu infections were much less common in household members who received the drug than among those who received a placebo. Only 1.9% of uninfected household contacts who took a single dose of baloxavir marboxil came down

The Things You Need To Know About Boronic Acids

A boronic acid is a compound related to boric acid in which one of the three hydroxyl groups is replaced by an alkyl or aryl group. As a compound containing a carbon–boron bond, members of this class thus belong to the larger class of organoboranes. What's the function about boronic acid? Boronic acids act as Lewis acids. Their unique feature is that they are capable of forming reversible covalent complexes with sugars,

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