openPR Logo
Press release

Safety And Effectiveness Of First-line Antihypertensive Drug Classes

Safety And Effectiveness Of First-line Antihypertensive Drug

For those with extremely high blood pressure, or hypertension, there are many initial medication options -- so many that it can be hard to know which one to use. Now, a Yale-coauthored paper in Lancet provides more information about the relative safety and effectiveness of different hypertension drugs in order to inform this critical treatment decision. The study reveals that angiotensin converting enzyme (ACE) inhibitors may not be the best choice for initial treatment.

Unprecedented in scale, the Lancet study pulled together the data of 4.9 million patients from nine institutional databases across four countries. The researchers used that data to compare the safety and effectiveness of the five classes of first-line hypertension drugs, including the popular ACE inhibitors. They were looking at how well each drug prevented the three main health consequences of hypertension -- heart attack, heart failure, and stroke -- and to what extent each drug caused 46 unwanted side-effects.

“This is a remarkable, massive, multinational study that has provided insights that can inform patient choices about hypertension treatment. What is distinctive is not only the size, but the advanced methods that optimize the trustworthiness of the results" said Dr. Harlan Krumholz, Yale cardiologist and author on the Lancet study.

The big data revealed patterns that would otherwise have taken 22,000 typical observational studies to spot, say the researchers. One key finding was that thiazide or thiazide-like diuretics are better at preventing heart attack, heart failure, and stroke than ACE inhibitors, while also being safer than ACE inhibitors. Taken individually, the differences in safety and effectiveness of the treatments might seem small, say the scientists, but at scale, they become significant. The researchers report that if the 2.4 million people in the study currently using ACE inhibitors had instead been using thiazide or thiazide-like diuretics, more than 3,100 major cardiovascular events could potentially have been avoided.

"Given that these drugs are inexpensive and have a long track-record, the findings should clearly turn us away from the prevalent practice of starting with ACE inhibitors. These findings support people opting for a thiazide diuretic over an ACE inhibitor for the initial treatment of hypertension," Krumholz concludes.

The paper was co-authored by members of the Observational Health Data Science and Informatics (OHDSI) network, a research and data-sharing collaborative based out of Columbia University, and is part of OHDSI's ongoing Large-Scale Evidence Generation and Evaluation across a Network of Databases (LEGEND) project, which uses big-data analysis to conduct observational research studies on hundreds of millions of patient records.

Distinctly dedicated to bringing differentiated and high-quality services to our global clients, Huateng Pharma is a highly proved provider of comprehensive pharmaceutical services. As a pharmaceutical intermediates manufacturer, we have very copious experience in regard to intermediates for the synthesis of drug substances. We can provide the synthesis of intermediates for antihypertensive drugs such as Selexipag, Olmesartan, Moxonidine, Valsartan and so on.

Lugu Business Plaza E1, Yuelu District, Changsha City, Hunan Province, P.R. China

Company name: Hunan Huateng Pharmaceutical Co. Ltd.
Address: Lugu Business Plaza E1, Yuelu District, Changsha City, Hunan Province, P.R. China
Zip code: 410205
Telephone: +86 731 89916275
Fax: +86 0731-82251112-818
Website: https://en.huatengsci.com
Email:sales@huatengusa.com

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Safety And Effectiveness Of First-line Antihypertensive Drug Classes here

News-ID: 2119008 • Views:

More Releases from Hunan Huateng Pharmaceutical Co. Ltd.

Huateng Pharma Supplies Minoxidil Intermediate 2,4-Diamino-6-chloropyrimidine (CAS NO.156-83-2)
Huateng Pharma Supplies Minoxidil Intermediate 2,4-Diamino-6-chloropyrimidine (C …
Minoxidil was first introduced by Upjohn Company of the United States, and was first used as an oral drug for the treatment of refractory hypertension in the 1970s. In later clinical applications, doctors observed hair regrowth and generalized excessive hair in balding patients, which led to the development of minoxidil preparations. Minoxidil can increase local blood supply, stimulate the proliferation and differentiation of hair follicle epithelial cells, so as to promote
Huateng Pharma Supplies Anti-diabetic API Intermediates With Huge Stock
Huateng Pharma Supplies Anti-diabetic API Intermediates With Huge Stock
Diabetes is a serious chronic disease characterized by elevated blood sugar concentrations associated with the effects of abnormal beta cell biology on insulin action. Diabetes occurs when the pancreas does not produce enough insulin or the body does not use the insulin it does produce efficiently. The most common forms of diabetes are type 1 diabetes and type 2 diabetes. Type 1 diabetes is characterized by insufficient insulin production and
Huateng Pharma Supplies Some Intermediates of CDK4/6 Inhibitors for Treatment of Advanced Breast Cancer
Huateng Pharma Supplies Some Intermediates of CDK4/6 Inhibitors for Treatment of …
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. In 2018, it is estimated that 627,000 women died from breast cancer - that is approximately 15% of all cancer deaths among women. While breast cancer rates are higher among women in more developed regions, rates are increasing in nearly every region globally. The majority
ADC Drugs For HER2 Positive Breast Cancer
ADC Drugs For HER2 Positive Breast Cancer
According to the latest data, breast cancer has overtaken lung cancer to become the most common cancer among women, and the death rate is the second highest among female tumors, seriously affecting the physical and mental health of women around the world. Patients with abnormal expression of human epidermal growth factor receptor (HER2) account for 15%-20% of all breast cancers, which is highly invasive and has poor prognosis. Although more drug

All 5 Releases


More Releases for ACE

Global Construction Insurance Market 2018-2025 | Allianz, AIG, Tokio Marine, ACE …
Researchmoz added Most up-to-date research on "Global Construction Insurance Market Size, Status and Forecast 2018-2025" to its huge collection of research reports. An insight on the important factors and trends influencing the market. This report focuses on the global Construction Insurance status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Construction Insurance development in United States, Europe and China. In 2017, the global Construction
Feel Ace NoBueno’s Tracks with your Soul
Trap is a musical genre influenced from hip hop and with a touch of Electronic Dance Music. Originated from South America, this genre has influences from dubstep and trance music as well. Trap music got its popularity in recent times. The dance music culture has got a smooth momentum via this genre’s fame. This genre is named Trap because it was grown by the rappers gathered in traps to express
ACE Health Solutions Goes Live
ACE Health Solutions (AHS), a full-service consulting company enabling independent physicians and multi-specialty clinics to optimize business practices, launched in late 2012. Since the launch, AHS has been working with local practices helping them implement electronic medical records (EMR) services and providing an array of other services. J. Chawla, ACE’s CEO and Founder, who has several years of experience working for successful healthcare organizations, is quoted in saying “the healthcare
Ace Appliance Repair
Ace Appliance Repair, an appliance repair service in Pittsburgh, PA, recently partnered with Prospect Genius, an online marketing firm, to assist area homeowners searching for low-priced appliance repairs. Through targeted search engine optimization (SEO) tactics, ACE Appliance repair is making it easier and quicker for local homeowners to locate them when performing Internet searches for appliance repair services and other needs, such as water heater installation. Joe Sazio, owner and founder
Ace Fancy Dress Eye Up Contact Lenses
Ace Fancy Dress has revealed that they have been super-busy planning for Halloween 2011 after a manic Halloween period in 2010. The website's merchandise team has been put through its paces as customers have shown a huge interest in contact lenses for Halloween resulting in a quest to source the scariest Halloween contact lenses that UK suppliers have to offer. With so many different styles, director Toby Spoerer indicated that
Ace Parking Expands to it's 7th State
SAN DIEGO, CA – Ace Parking Management, Inc., one of North America’s largest privately-owned parking management companies, now has operations in Omaha, Nebraska, which is the company’s 7th state in which they operate. “February 1st, 2011 was an exciting day for Ace Parking as we expanded operations into Nebraska,” said Keith Jones, Managing Principle. “When my grandfather started Ace Parking in 1950 with one parking lot in downtown San Diego, I