openPR Logo
Press release

New Therapy For Lung Cancer And Related Secondary Tumors

New Therapy For Lung Cancer And Related Secondary Tumors

In 20 - 40% of patients with cancer, metastasis (the development of secondary tumors) in the central nervous system (CNS) occurs. CNS metastatis impacts negatively on a patient's quality of life, and is associated with a poor health prognosis. In a form of cancer known as ALK-rearranged non-small-cell lung cancer (NSCLC), CNS metastasis is known to persist when drugs targeting primary tumors are used. Now, Seiji Yano from Kanazawa University and colleagues have investigated the origins for the resistence to such drugs, and tested a new therapeutic strategy on a mouse model.

The researchers looked at the drug alectinib. Although used in standard treatments for advanced ALK-rearranged NSCLC, approximately 20 - 30% of patients treated with alectinib develop CNS metastatis, which is attributed to acquired resistance to the drug.

By treating mice first injected with tumor cells with alectinib daily for 16 weeks, the scientists obtained a mouse model displaying alectinib resistance. By biochemical analyses of the mouse brains, Yano and colleagues were able to link the resistance to the activation of a protein known as epidermal growth factor receptor (EGFR). This activation is, in turn, a result of an increase in production of amphiregulin (AREG), a protein that binds to EGFR and in doing so 'activates' it.
Based on this insight, the researchers tested the effect of administering drugs used for inhibiting the action of EGFR in combination with alectinib treatment. The experiments showed that a combination treatment of alctinib with either erlotinib or osimertinib -- two existing EGFR-inibiting drugs -- prevented the progression of CNS metastasis, controlling the condition for over 30 days.

The scientists conclude that the combined use of alectinib and EGFR-inhibitors could overcome alectinib resistance in the mouse model of leptomeningeal carcinomatosis (LMC), a particular type of CNS metastasis.

Background

Non-small-cell lung cancer

Non-small-cell lung carcinoma (NSCLC) and small-cell lung carcinoma (SCLC) are the two types of lung cancer. 85% of all lung cancers are of the NSCLC type. NSCLCs are less sensitive to chemotherapy than SCLCs, making drug treatment of the highest importance. Alectinib is a drug used for treating NSCLC, with good efficiency. However, 20-30% of patients taking the drug develop secondary cancer in the central nervous system (CNS), which is associated with an acquired resistance to alectinib. Seiji Yano from Kanazawa University and colleagues have now made progress towards a novel therapy against this resistance: a combination of alectinib with other drugs.

Epidermal growth factor receptor inhibitors

The drugs that Yano and colleagues tested in combination with alectinib on a mouse model were of a type known as epidermal growth factor receptor (EGFR) inhibitors, including osimertinib and erlotinib. Both are being used as medication for treating NSCLC. The former was approved in 2017 as cancer treatment by the U.S. Food and Drug Administration and the European Commission. Yano and colleagues obtained results showing that EGFR inhibitors counteract resistance to alectinib and have therefore potential in novel therapies for NSCLC and secondary cancers in the CNS.

Huateng Pharma is a professional pharmaceutical intermediates supplier with a 34000m2 industrial park and a 5000m2 R&D base. We are able to provide Anti-Cancer intermediates such as Carfilzomib intermediates, Elagolix intermediates, Palbociclib intermediates, Alectinib intermediates and so on.

About us
Hunan Huateng Pharmaceutical Co. Ltd.
Lugu Business Plaza E1, Yuelu District, Changsha City, Hunan Province, P.R. China
zip code: 410205
Telephone: +86 731 89916275
Fax: +86 0731-82251112-818
Website: https://en.huatengsci.com
Email:sales@huatengusa.com

Huateng Pharma is a leading and professional manufacturer which can provide PEG derivatives, biochemical reagents, pharmaceutical intermediates, APIs, Vitamin D Derivatives and targeted anti-tumor drugs. It is committed to providing cost-effective pharmaceutical products and services to customers around the world with the belief of “Strive for the Human Health".

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release New Therapy For Lung Cancer And Related Secondary Tumors here

News-ID: 2197042 • Views: 499

More Releases from Hunan Huateng Pharmaceutical Co. Ltd.

Huateng Pharma Develops Systemic Antiparasitic Agent Fluralaner
Fluralaner is a systemic insecticide and acaricide that can be administered orally or topically. Bravecto is the trade name. The U.S. Food and Drug Administration (FDA) approved it for flea treatment in dogs under the trade name Bravecto in May 2014 and for topical treatment in cats in November 2019. Fluralaner is a novel isooxazoline broad-spectrum insecticide that acts on γ-aminobutyric acid (GABA) receptors and has good activity against ticks, fleas,
Huateng Pharma Develops Intermediates of Carfilzomib For Multiple Myeloma
Carfilzomib, a proteasome inhibitor, is indicated for the treatment of patients with multiple myeloma. Multiple myeloma (multiple myeloma, MM) is a malignant tumor originating from the B cell lineage, characterized by the clonal proliferation of malignant plasma cells in the bone marrow microenvironment, causing fractures and bone marrow failure, and is the second most common blood system disease in the world Tumors cannot be cured by traditional chemotherapy regimens. Bortezomib is the
Huateng Pharma Develops Intermediates of Semaglutide For TD2
According to the latest IDF Diabetes map, the global prevalence of diabetes reached 10.5% in 2021, with 537 million adults living with diabetes. China has become a disaster zone for diabetes, with the largest number of adults with diabetes in the world. In the past 10 years (2011-2021), the number of people with diabetes in China increased from 90 million to 140 million, an increase of 56%. The total number
The Future of Treatment For Type 2 Diabetes
Although the treatment of type 2 diabetes (T2DM) has made impressive progress in the past few decades, researchers are constantly searching for new treatments. How to better control blood glucose and reduce diabetes-related complications has become a hot topic in the field of T2DM research. Previously, The Lancet Diabetes Endocrinology published an in-depth review detailing novel therapeutic targets for T2DM, mechanisms of drug action, and corresponding hypoglycemic efficacy. It involves innovation

All 5 Releases


More Releases for SCLC

Small Cell Lung Cancer (SCLC) Therapeutics Market Research & Outlook 2020
Impact Analysis of Coronavirus Disease (Covid-19) on Small Cell Lung Cancer (SCLC) Therapeutics Market Facto Market Insights published a title on “Small Cell Lung Cancer (SCLC) Therapeutics Market – 2020-2026”, to its collection. The study on the small cell lung cancer (SCLC) therapeutics market defines the analysis of all the segments, along with the market sizing, year-over-year growth analysis and structure of the industry. The research report also includes the analysis
OpportunityAnalyzer: Small Cell Lung Cancer (SCLC) - Opportunity Analysis and Fo …
Researchmoz added Most up-to-date research on "OpportunityAnalyzer: Small Cell Lung Cancer (SCLC) - Opportunity Analysis and Forecasts to 2024" to its huge collection of research reports. Initially considered a curable disease due to substantial sensitivity to first-line chemotherapies, small cell lung cancer (SCLC) remains a fatal disease with poor outcomes due to high relapse rates, with the majority of patients surviving one year or less after diagnosis. Unlike non-small cell lung
Overview of Small cell lung cancer (SCLC) Industry : Market Development, Analysi …
ALBANY, NY, April 5, 2017 : ResearchMoz presents professional and in-depth study of "Small cell lung cancer (SCLC)- Market Insights, Epidemiology and Market Forecast-2023". DelveInsights Small cell lung cancer (SCLC) - Market Insights, Epidemiology and Market Forecast-2023 Reports provides an overview of the disease and global market trends of the Indication for the seven major markets ie: United States, EU5 (France, Germany, Italy, Spain, UK) and Japan. The Report covers
Pipeline Analysis Of Small Cell Lung Cancer (SCLC) Market - Insights, Epidemiolo …
ResearchMoz presents this most up-to-date research on "Pipeline Analysis Of Small Cell Lung Cancer (SCLC) Market - Insights, Epidemiology And Forecast To 2023". DelveInsights Small cell lung cancer (SCLC) - Market Insights, Epidemiology and Market Forecast-2023 Reports provides an overview of the disease and global market trends of the Indication for the seven major markets ie: United States, EU5 (France, Germany, Italy, Spain, UK) and Japan. The Report covers the therapeutics
Small cell lung cancer (SCLC)- Market Insights, Epidemiology and Market Forecast …
DelveInsights Small cell lung cancer (SCLC) - Market Insights, Epidemiology and Market Forecast-2023 Reports provides an overview of the disease and global market trends of the Indication for the seven major markets ie: United States, EU5 (France, Germany, Italy, Spain, UK) and Japan. The Report covers the therapeutics market revenue; average cost of therapy, treatment practice and Small cell lung cancer (SCLC) forecasted market share for ten years to 2023
Small Cell Lung Cancer (SCLC) Treatment Market Revenue and Value Chain 2016-2026
According to the World Health Organization (WHO), 8.2 million people died from cancer around the world in 2012, and cancer is now one of the leading causes of death. Lung cancer is the leading cancer type and caused 1.59 million deaths in 2012. Small cell lung cancer is two types - Oat cancer Combiner small cell cancer The major risk factors for small cell lung