Press Releases from Pharma Proff (76 total)
Interleukin-6 (IL-6) Inhibitors Analysis, Clinical Trails and Developments
Interleukin-6 (IL-6) inhibitors currently exhibit a proliferating pipeline with 25+ therapeutic candidates.
IL-6 is a cytokine encoded by IL-6 gene, which helps in the maturation of B cells and is actively involved in the inflammatory response. The IL-6 protein is primarily produced at the sites of acute and chronic inflammation, where it is secreted into the serum and brings a transcriptional inflammatory response through IL-6? receptor. This protein is assumed to…
Retinitis Pigmentosa Therapeutics Analysis, Clinical Trials and Other Developmen …
Retinitis pigmentosa therapeutics currently exhibits a proliferating pipeline with 25+ therapeutic candidates.
Retinitis pigmentosa (RP) is a group of hereditary disorders that lead to the breakdown and loss of cells in the retina. Mutation in genes encoding the proteins required by retinal cells for their proper functioning, results in occurrence of RP. The disease results in partial vision loss during the earlier stage of the disease, which may lead to complete…
Probiotics Therapeutics -Pipeline Analysis 2018, Clinical Trials & Results, Pate …
Probiotics are live microorganisms that produces beneficial effects in human gut. Probiotics can be taken as a dietary supplement. They prevent diarrhoea and help to reduce the symptoms of irritable bowel syndrome.
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Probiotics comprise of a variety of microorganisms belonging to the Lactobacillus and Bifidobacterium groups. The only yeast probiotic that has proven to be effective is Saccharomyces boulardii. According to researchers, probiotics are effective in…
Niemann-Pick Disease Type C (NPC) Therapeutics Pipeline to Witness Significant G …
Niemann-Pick disease is divided into four main types: type A, type B, type C1, and type C2. These types are classified on the basis of genetic cause and signs and symptoms of the disease. NPC is identified as a rare genetic disorder in which the body is unable to transport cholesterol and lipids inside the cells. This causes accumulation of these substances within various tissues of the body. These substances…
Hepatorenal Syndrome Therapeutics Pipeline Analysis 2018, Clinical Trials & Resu …
Hepatorenal syndrome (HRS) is a reversible functional renal impairment, that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure. It is characterized by a marked reduction in glomerular filtration rate and renal plasma flow, in the absence of other causes of renal failure.
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The symptoms of hepatorenal syndrome are fatigue, abdominal pain, malaise, ascites, jaundice, splenomegaly, and hepatomegaly. There are two…
Progressive Supranuclear Palsy Headed Toward Cure
Progressive supranuclear palsy (PSP) is a brain disorder which impacts vision, cognition, movement, and speech. This disease results in weakness by affecting certain parts of the brain above the cell clusters, known as nuclei (supranuclear), which are involved in controlling eye movements. It usually manifests in mid-to late adulthood, and the survival rate of people suffering from PSP is five to nine years after the disease first appears. It is…
Novel Drug Delivery Systems to Augment Presbyopia Therapeutics Pipeline
Presbyopia is a common vision disorder that manifests with increasing age. With age, the ciliary muscles of the eye start losing their flexibility that leads to the eye lens losing its flexibility as well. The eye gradually loses its ability to focus light directly on to the retina, and the image ends up forming behind it. This results in poor visibility of objects that are close to the eye. The…
Interleukin-6 Inhibitors Therapeutics Pipeline a Solution to Various Diseases
Interleukin-6 (IL-6), an inflammatory cytokine involved in various biological processes, ranging from immune system activation and hematopoiesis to inflammation and regulating oncogenesis by taking part in gene activation and cell proliferation, survival, and differentiation. The receptor for this ligand (IL-6) is composed of two subunits — an alpha subunit responsible for ligand specificity, and glycoprotein (GP) 130, a receptor that other cytokines in the IL-6 family share. The Ras-mediated and…
Herpes Simplex Virus (HSV) and Human Papilloma Virus (HPV) Infections Epidemiolo …
HPV is a group of more than 200 related viruses, which spreads mostly through anal, oral, and vaginal sex. The sexually transmitted HPV infections are categorized into two groups: low-grade, and high-grade HPVs. HPV is generally transmitted through vaginal intercourse, oral and anal sex, and also by intimate skin-to-skin contact. The condoms and dental dams can reduce the likelihood of HPV transmission. Some of the risk factors of this infectious…
Friedreich’s Ataxia (FRDA) Therapeutics Pipeline to Witness Significant Growth …
Friedreich’s ataxia (FRDA) is an inherited autosomal recessive genetic condition that progressively damages the nervous system, with a typical age of onset between 10 years and 15 years. The risk factors associated with FRDA are diabetes mellitus and heart diseases, including cardiomyopathy and cardiac arrhythmias. FRDA occurs due to mutation in the frataxin (FXN) gene, which is inherited from parents, leading to the presence of mutations in both copies of…
Strategic Advancements in Drug Development are Beholding the Growth of Proteasom …
Proteasomes are small, barrel-formed structures found in cells having a function of degrading the misfolded and non-useful proteins inside the cells. Proteasome inhibitors focus on proteasomes in the disease cells and hinder their action by binding to them. Once, proteasome action is lost, the proteins begin to assemble inside the malignant cells and later burst due to overaccumulation, causing cell death. The proteasome inhibitors are being considered for the treatment…
Neurofibromatosis (NF) Therapeutics Pipeline to Witness Significant Growth due t …
Neurofibromatosis (NF) is a genetic disorder that causes tumors on nerve tissues. These are usually non-cancerous, but few can be developed into cancer. The disorder becomes prominent by the age of 10–15 years. The NF is of three types: NF1, NF2, and schwannomatosis. NF1 is caused due to the defect in chromosome 17, NF2 is a result of defect in chromosome 22, and schwannomatosis is a rare form of NF…
Oral Mucositis Therapeutics Pipeline to Witness Significant Growth due to Positi …
Oral mucositis is an acute inflammation of the oral mucosa, which is a common side effect of chemotherapy and radiotherapy. The inflammation leads to the formation of ulcers and infections in mouth. It usually occurs in the people with head and neck cancer and lasts for one week to six weeks or more. Lack of nutrition due to inability to eat and severe pain in mouth are some of the…
Strategic Advancements in Drug Development are Beholding the Growth of OX40 Rece …
OX40 receptor holds a place in the tumor necrosis factor (TNF) superfamily whose interactions play an essential role in causing of different immune system ailments. OX40 interactions are amongst the most critical pathways that decide the extent of CD4 and CD8 T cell resistance. OX40 interactions also possess a crucial role in T cell immunity. OX40 is a co-stimulatory receptor that binds to OX40-Ligand (OX40L) to initiate a cascade, which…
PKD Therapeutics Pipeline Analysis by Phase, Molecule Type, Route of Administrat …
Polycystic kidney disease (PKD) is a genetic disorder that primarily affects kidneys. It causes fluid-filled cysts to grow inside the kidneys, which increase the size and damage tissues of the kidneys. Symptoms of the disease include abdomen and back pain, urinary tract infection, frequent urination, blood in urine, kidney stones, and others. There are mainly two types of PKD: autosomal dominant PKD (ADPKD) and autosomal recessive PKD (ARPKD). The main…
Angiopoietin (ANG) Inhibitors Therapeutics Clinical Trials & Results | Regeneron …
Angiopoietin (ANG) receptor plays a crucial role in regulation of vascular permeability and pathological vascular remodelling during tumour angiogenesis, metastasis and inflammation. Thus, it has emerged as a new clinical approach for the development of therapeutics which treat cancer and ophthalmological diseases.
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The exclusive function of these receptors in vascular stabilization also makes it an attractive target in organ transplantation, sepsis, vascular complications of diabetes…
Spleen Tyrosine Kinase (Syk) Inhibitor Therapeutics Clinical Trials & Results | …
Spleen tyrosine kinase (Syk) is a protein that belongs to the family of tyrosine kinases with an ability to initiate the inflammatory responses, by connecting immune cell receptors to intracellular signaling pathways. Therefore, Syk is an attractive target for improving the symptoms related to acute and chronic inflammation. In addition, the role of protein is recognized as a promoter in various types of cancers ranging from leukemia to retinoblastoma.
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Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors Therapeutics Clinical Trial …
Glycogen synthase kinase 3 beta (GSK-3β) is an attractive target for the treatment of psychiatric disorders and neurodegenerative diseases. Many GSK-3β inhibitors have been developed for the treatment of different central nervous system disorders. But, for an effective therapy, high IC50 values should be avoided and ATP-competition should be reduced during enzyme-compound binding. Studies suggested that ATP non-competitive GSK-3 inhibitors such covalent inhibitors and allosteric modulators are emerging as a…
Clinical Trials & Results of Hepatocyte Growth Factor (HGF) Inhibitor Therapeuti …
Hepatocyte growth factor (HGF) is secreted by human pancreatic stellate cells and present predominantly on cancer cells. Thus, HGF inhibitors has emerged as an effective therapy in preventing local tumor growth. Also, studies have demonstrated that HGF inhibitors are significantly more effective than Gemcitabine in inhibiting tumor angiogenesis and metastasis.
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Studies have demonstrated that the HGF inhibitor can be a novel therapeutics that can be developed…
Hyperlipidemia Therapeutics Pipeline to Witness Significant Growth due to Positi …
Hyperlipidemia is unsuitable increase of cholesterol in blood, which can be inherited or acquired. Hypertriglyceridemia, and hypercholesterolemia are the two types of hyperlipidemia. Hyperlipidemia can be a result of various food products such as ice cream, cheese, red meat, and others. Furthermore, accumulation of cholesterol takes place even in arteries, which can result in high blood pressure. This can also result in clotting of blood, which may eventually lead to…
Pancreatic Cancer Therapeutics Market to Witness Significant Growth due to Incre …
Pancreatic cancer occurs when malignant cells develop in the part of pancreas, resulting in the formation of a tumor. Pancreatic cancer typically spreads rapidly to nearby organs. It is rarely detected in its early stages.
Diabetes is one of the major signs of pancreatic cancer, especially occurs with weight loss, jaundice or pain in the upper abdomen that spreads to the back. Jaundice, digestive problems, blood clots, and pancreatitis are some…
Hyperhidrosis Therapeutics Pipeline to Witness Remarkable Growth due to Increase …
Hyperhidrosis refers to excessive sweating from some body parts, including palms, heads, feet, or underarms. It is mainly categorized into two types: primary hyperhidrosis and secondary hyperhidrosis. It can be diagnosed by physical examinations of the excessively sweating body parts and by conducting a sweat test. The available treatment options for hyperhidrosis include Botulinum toxin, prescription medicines, antiperspirants, and iontophoresis.
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Botox injection (Allergan plc) and Qbrexza…
Positive Clinical Trials are Responsible for the Growth of Diabetic Foot Ulcer T …
A diabetic foot ulcer is an open sore or wound that occurs in approximately 15% of patients with diabetes and is commonly located in the bottom of the foot. People with diabetes are at higher risk of developing neuropathy as increased blood glucose levels lead to nerve damage. Poor blood circulation, hyperglycemia, and deprived nutrition are some other risk factors associated with the onset of diabetic foot ulcer.
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Pancreatic Cancer Epidemiology Analysis by Stage, Sex & Age Group
Pancreatic cancer is defined as the development of tumor and uncontrolled growth of cells in the pancreas. There are mainly two different types of pancreatic cancer: exocrine and endocrine, depending upon the part of pancreas affected. Some of the risk factors associated with pancreatic cancer include environmental toxins; hereditary factors; age; gender; and lifestyle factors, such as smoking, excess weight, and high consumption of alcohol. The disease is observed to…
Benign Prostatic Hyperplasia (BPH) Therapeutics Pipeline to Witness Significant …
BPH can be identified as enlargement of prostate gland, a condition affects majority of male population. It is non-cancerous and goes through two main growth periods as a man age. The first phase begins in puberty, when the size of prostate becomes double. The second phase of prostate growth normally begins in the second decade of life. It is observed that men with a family history of BPH and chronic…
Bronchiectasis Therapeutics Pipeline to Witness Significant Growth due to Positi …
Bronchiectasis, a chronic airways infection, affects lungs and widens bronchial trees. This leads to gradual loss of mucus clearing ability, which increases growth of bacteria. Bronchiectasis can lead to serious health problems such as respiratory failure, heart failure, and atelectasis. The disease often begins in childhood and can be acquired or congenital. Signs and symptoms of bronchiectasis are excessive tiredness or difficulty in concentrating and breathing, anxiety, cough incontinence, depression,…
Various Advancements in the Drug Development Technologies are Beholding the Grow …
Presbyopia is an age-related eye disorder, which affects the near sight vision. Primary cause of the disease is loss of flexibility of eye lenses present in cornea. Due to this, patients face difficulty in day-to-day activities like reading, blurred vision, headaches, and eyestrain. Side-effects of drugs such as diuretics, anti-depressants, and anti-histamines can also lead to the occurrence of presbyopia. Additionally, diseases, such as diabetes, cardiovascular diseases, and multiple sclerosis,…
Hemochromatosis Therapeutics Pipeline to Witness Significant Growth due to Posit …
Hemochromatosis, also known as iron overload, is identified as increased level of iron in the body. It has symptoms such as joint pain, weight loss, erectile dysfunction in men, and irregular menstrual cycle in women. Hemochromatosis can be categorized into two types: primary hemochromatosis and secondary hemochromatosis. Primary hemochromatosis is genetic disorder; however, secondary hemochromatosis occurs due to medical conditions such as anemia, thalassemia, and others.
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Androgenetic Alopecia Therapeutics Pipeline to Witness Significant Growth due to …
Androgenetic alopecia is a genetic disorder of patterned hair loss that affects both men and women. The disorder shortens hair growth cycle due to excess of androgen, which eventually delays hair growth. Some of the major symptoms include gradual recession of frontal hairline, increased hair fall, bitemporal recession of hair, and thinning of the hair. The symptoms start appearing at the age of 20 and are seen to be prominent…
Hyperinsulinemia Therapeutics Pipeline Analysis 2018
Hyperinsulinemia is a medical condition which is characterized by increased amount of insulin in blood. The primary cause of the disease is insulin resistance, which can also result in the development of type 2 diabetes.
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Insulinoma and nesidioblastosis are some other causes of hyperinsulinemia. Major symptoms of the disease are intense hunger, concentration difficulties, fatigue and obesity. People who have higher triglyceride and uric acid level,…
Hepatorenal Syndrome Therapeutics Pipeline Analysis 2018 | Cumberland Pharmaceut …
Hepatorenal syndrome (HRS) is a reversible functional renal impairment, that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure. It is characterized by a marked reduction in glomerular filtration rate and renal plasma flow, in the absence of other causes of renal failure.
Download the sample report at: https://www.pharmaproff.com/request-sample/1030
The symptoms of hepatorenal syndrome are fatigue, abdominal pain, malaise, ascites, jaundice, splenomegaly, and hepatomegaly. There are two…
Hepatitis E Therapeutics Pipeline Analysis 2018
Hepatitis E is a liver disease caused by infection due to a virus known as hepatitis E virus (HEV). This disease can cause swelling in liver. Some of the common symptoms are mild fever, feeling of tiredness, feeling sick to stomach, and belly pain.
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The World Health Organization (WHO) estimates released in 2018 stated that, every year, an estimated 20 million HEV infections worldwide, leading to…
Gastroenteritis Therapeutics Pipeline Analysis 2018
Gastroenteritis, also known as infectious diarrhoea, is an inflammatory disease caused by bacteria, viruses, or parasites through contaminated food and water.
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The disease can be symptomatized by vomiting, nausea, cramping, and diarrhoea. Dehydration, joint inflammation, conjunctivitis, salmonella infection, persistent diarrhoea syndrome, lactose intolerance, and irritable bowel syndrome are among the several complications associated with gastroenteritis.
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The treatment medications for the disease…
Functional Dyspepsia Therapeutics- Pipeline Analysis 2018
Functional dyspepsia, also known as non-ulcer dyspepsia, is a gastrointestinal disorder that causes peristalsis and sensations in the upper digestive tract. Inflammation of the stomach or duodenum, excessive acid secretion, psychological factors, lifestyle and diet influences, food allergies, Helicobacter pylori infection, and side effects of medications are some causes of functional dyspepsia.
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The risk factors associated with this disease are smoking, consumption of alcohol, consumption of…
Wegener’s Granulomatosis Therapeutics - Pipeline Analysis 2018, Clinical Trial …
Wegener’s granulomatosis, also known as granulomatosis with polyangiitis, is a type of an inflammatory and autoimmune disorder that limits the blood flow to organs, leading to organ damage.
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Some signs and symptoms observed in the patients are sinus pain, discolored body fluid, rhinorrhea, joint pain, skin lesions, and tiredness. Some of the complications associated with the diseases are hearing loss, proptosis, blindness, end-stage renal disease,…
Sarcoidosis Therapeutics - Pipeline Analysis 2018, Clinical Trials & Results
Sarcoidosis is an inflammatory disorder that affects many organs in the body, such as lymph glands and lungs. Abnormal nodules are formed in the affected organs, impacting the structure and function of the organ during sarcoidosis.
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The symptoms associated with this disease are fatigue; cough; swollen and painful joints; red and teary eyes or blurred vision; tender reddish bumps or patches on the skin; enlarged…
Primary Immune Deficiency Diseases Therapeutics - Pipeline Analysis 2018, Clinic …
Primary immune deficiency diseases are rare and genetic disorders, that are characterized by an impaired immune system. Some of the symptoms observed in the patients with these diseases are blood disorders, autoimmune disorders, recurrent pneumonia, inflammation of internal organs, and digestive problems.
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Primary immune deficiency diseases can occur due to B-cell deficiencies, T-cell deficiencies, defective phagocytes, combination of B- and T-cell deficiencies, and complement deficiencies.…
Kidney Transplant Rejection Therapeutics - Pipeline Analysis 2018, Clinical Tria …
Kidney transplant rejection occurs due to an immune response toward the foreign antigens from the donor kidney. It is categorized into three different types; hyper-acute, acute, and chronic kidney transplant rejection.
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Immunosuppressants are commonly prescribed to suppress the immune system, allowing the kidney to function in the recipient. Some other factors that may contribute to kidney transplant rejection are blood clot after surgery, fluid collection and…
Hypersensitivity Therapeutics - Pipeline Analysis 2018, Clinical Trials & Result …
Hypersensitivity is a group of undesirable reactions that are produced by normal immune systems, due to allergies and autoimmune disorders in body. These are considered as an over-reaction by the immune system and can be damaging, uncomfortable, or occasionally incurable.
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Hypersensitivity is also defined as an abnormal or pathologic immune reaction that is caused by an immune response to repeated exposure to an antigen. It…
Bacterial Endocarditis Therapeutics - Pipeline Analysis 2018, Clinical Trials & …
Bacterial endocarditis is an infection of inner lining of the valves and heart chamber. This infection can cause serious inflammation in heart and can develop fatal complications.
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It has been observed that patients who have undergone implantations like heart valve replacement, or have congenital heart defects are more susceptible to this disease. Bacterial endocarditis can be diagnosed by blood tests, echocardiography, and electrocardiogram.
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Blepharitis Therapeutics- Pipeline Analysis 2018, Clinical Trials & Results
Blepharitis is an inflammatory disorder of eyelids and can be categorized into two types; anterior and posterior blepharitis. The inflammation at the outside front of the eyelid is anterior blepharitis, whereas, inflammation at the inner eyelid is posterior blepharitis.
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The major complications associated with blepharitis are the sty (acute infection of oil glands in eye), chalazion (painless lump due to inflammation of oil glands in eye),…
Chagas Disease (American Trypanosomiasis) Therapeutics- Pipeline Analysis 2018, …
Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening condition caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). Chagas disease occurs principally in the continental part of Latin America, and not in the Caribbean isles.
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Chagas disease presents itself in two phases including acute and chronic phase. The initial acute phase lasts for about two months after infection.
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The…
Community Acquired Pneumonia Therapeutics- Pipeline Analysis 2018, Clinical Tria …
Community acquired pneumonia is a type of pneumonia acquired in extended care facilities. This condition can cause decreased lung function, fever, chest pain, dyspnea, and cough.
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The sign and symptoms of community acquired pneumonia include chest pain, coughing, fever, shallow breathing, diarrhea, nausea, vomiting, excessive fatigue, hemoptysis, and joint pain. Community acquired pneumonia is generally caused by Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumonia,…
Cryptosporidiosis Therapeutics- Pipeline Analysis 2018, Clinical Trials & Result …
Cryptosporidiosis is a severe form of illness caused by parasites of various Cryptosporidium species. A person can be infected by parasites by having contaminated food and water or coming in contact with contaminated places.
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Some of the symptoms observed in people with cryptosporidiosis are fever, nausea, vomiting, stomach pain, and weight loss. People with weakened immune system, acquired immunodeficiency syndrome (AIDS), cancer, or who have…
Diphtheria Therapeutics- Pipeline Analysis 2018, Clinical Trials & Results
Diphtheria is an infectious and vaccine preventable disease caused by Corynebacterium diphtheriae. It is generally characterized by upper respiratory tract infection, and the most common sites for this disease are pharynx and tonsils.
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Some of the symptoms include fever, sore throat, swollen glands, and weakness. Corynebacterium diphtheriae is a gram-positive bacterium that carries a gene for diphtheria toxin.
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Most of…
Gram-Positive Bacterial Infections Therapeutics- Pipeline Analysis 2018, Clinica …
Gram-positive bacterial infections are caused by gram-positive bacteria, such as Staphylococcus aureus and Enterococcus spp. This infection sometimes become fatal in the immune-compromised person, and it is generally found in new-born.
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The infection when contracted during pregnancy can cause chorioamnionitis and postpartum infections. Further, urinary tract infections associated with the bacteria can also cause premature birth.
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Some of the characteristics…
Haemophilus Infections Therapeutics- Pipeline Analysis 2018, Clinical Trials & R …
Haemophilus infections are the bacterial infections including septic arthritis, meningitis, pneumonia, otitis media, sinusitis, conjunctivitis, tracheobronchitis, and acute epiglottitis caused by the Haemophilus sp.
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There are several pathogenic species of Haemophilus and the most common is H. influenzae with six different encapsulated serotypes and numerous strains. Haemophilus infections can be diagnosed by culture of blood and body fluids and is treated usually by various antibiotics depending…
Herpes Labialis Therapeutics- Pipeline Analysis 2018, Clinical Trials & Results
Herpes labialis, also known as oral herpes, is a mouth infection which leads to the development of small, painful blisters on gums, throat, and lips. The blisters are caused by herpes simplex virus, which is highly contagious and is known to infect a larger portion of population in the U.S.
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The common symptoms observed during this infection are appearance of small painful blisters, fever, sore…
Hospital Acquired Pneumonia (HAP) Therapeutics- Pipeline Analysis 2018, Clinical …
Hospital acquired pneumonia (HAP) is a lung infection that occurs during hospital stay. HAP can spread via health care workers, who may pass germs from their hands or clothes from one patient to another.
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This is why hand-washing, wearing gowns, and using other safety measures is so important in hospitals and other healthcare settings. It has been observed that HAP may develop at least 48…
Bone Metastases Therapeutics- Pipeline Analysis 2018, Clinical Trials & Results, …
Bone metastases is a common form of cancer of the skeleton that inhabits in bone marrow and stimulates the local bone activity.
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In this condition, the normal bone homeostasis disrupts which leads to the development of the tumour. Some of the major symptoms observed in patients with bone metastases are bone pain, spinal cord compression, and high blood calcium levels.
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