openPR Logo
Press release

Progressive Supranuclear Palsy Headed Toward Cure

07-17-2019 03:15 PM CET | Health & Medicine

Press release from: PHarma Proff

Progressive supranuclear palsy (PSP) is a brain disorder which impacts vision, cognition, movement, and speech. This disease results in weakness by affecting certain parts of the brain above the cell clusters, known as nuclei (supranuclear), which are involved in controlling eye movements. It usually manifests in mid-to late adulthood, and the survival rate of people suffering from PSP is five to nine years after the disease first appears. It is also referred to as Steele–Richardson–Olszewski syndrome.

Download the report sample at:

Signs and Symptoms

The signs and symptoms of PSP vary on an individual basis, and the first symptom is usually the loss of balance while walking. Patients may experience unexplained falls or stiffness in gait. With disease progression, problems in controlling eye movements and blurring of vision become the common observations. Slowing of the eye movements is the definitive clue for a proper PSP diagnosis. Alterations of mood and behavior, such as apathy and depression, are also exhibited by patients. Other symptoms of PSP are a mask-like facial expression, slowed movements, and monotone speech.


The exact cause of PSP is not yet established; the symptoms are caused by the gradual deterioration of brain cells in certain areas, specifically the brain stem. Abnormal tau protein deposits in the nerve cells are the hallmark of the disease. This protein is associated with microtubules, which help the axons transmit information through the nerves. Abnormal protein aggregates in the surrounding cells to form protein clumps, thereby spreading throughout the nervous system. Another possible theory is that of cellular damage by free radicals, which are continuously generated by cells during normal metabolism; these damage other molecules under certain circumstances.

Diagnostic Tests

There are no specific laboratory or imaging tests currently available for a definitive PSP diagnosis. It is often misdiagnosed as the symptoms are comparatively rare and similar to other movement disorders, such as Parkinson’s disease. Brain shrinkage may show on magnetic resonance imaging (MRI) scans, and a positron emission tomography (PET) scan may be used to detect early signs that may not appear on the MRI.


No medication or surgical procedure is available for PSP currently, and the treatment is done based on the appearance of symptoms. Antiparkinsonian agents such as levodopa help in managing stiffness, slowness, and balance, but the effect is minimal and doesn’t last long. Anti-depressants are also prescribed to control excessive drooling and for pain relief, whereas botulinum injections are used for treating excessive eye closing.

Get the detailed analysis at:

PSP therapeutics Pipeline

The PSP therapeutics pipeline is witnessing growth due to the receipt of the orphan drug status by several pharmaceutical companies for their under-development drugs. A provision of the U.S. Food and Drug Administration, the Orphan Drug Act grants a special status to a biological product or drug for the treatment of a rare condition upon a sponsor’s request. Certain incentives, such as tax credits, federal grants and a waiver of the filing fees, which is mentioned in the Prescription Drug User Fee Act, are provided under this designation.

One of the drugs in the PSP therapeutics pipeline is BIIB092. Being developed by Biogen Inc., it was under the Phase II development stage in November 2017. Also known as BMS-986168, it is a humanized monoclonal antibody, which works by inhibiting the tau protein. It is being developed to be administered through the intravenous route. Bristol-Myers Squibb Company gave the drug licensing rights to Biogen Inc.

Therefore, with the entry of more companies, the pipeline would advance, hopefully finding a definitive treatment for PSP.

Contact Us:
Pharma Proff
Toll-free: +1-888-778-7886 (USA/Canada)
International: +1-347-960-6455

About Us:
Pharma Proff, is a frontline market intelligence and consulting solutions provider catering to the information and data needs of burgeoning sectors across the world, including pharmaceutical and healthcare. With meticulously curated research reports on the industry landscape, we empower companies in the healthcare and pharmaceutical sectors to make informed business decisions and base their marketing strategies with astuteness.

This release was published on openPR.

Permanent link to this press release:

Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Progressive Supranuclear Palsy Headed Toward Cure here

News-ID: 1806161 • Views: 652

More Releases from PHarma Proff

Interleukin-6 (IL-6) Inhibitors Analysis, Clinical Trails and Developments
Interleukin-6 (IL-6) inhibitors currently exhibit a proliferating pipeline with 25+ therapeutic candidates. IL-6 is a cytokine encoded by IL-6 gene, which helps in the maturation of B cells and is actively involved in the inflammatory response. The IL-6 protein is primarily produced at the sites of acute and chronic inflammation, where it is secreted into the serum and brings a transcriptional inflammatory response through IL-6? receptor. This protein is assumed to
Retinitis Pigmentosa Therapeutics Analysis, Clinical Trials and Other Developmen …
Retinitis pigmentosa therapeutics currently exhibits a proliferating pipeline with 25+ therapeutic candidates. Retinitis pigmentosa (RP) is a group of hereditary disorders that lead to the breakdown and loss of cells in the retina. Mutation in genes encoding the proteins required by retinal cells for their proper functioning, results in occurrence of RP. The disease results in partial vision loss during the earlier stage of the disease, which may lead to complete
Probiotics Therapeutics -Pipeline Analysis 2018, Clinical Trials & Results, Pate …
Probiotics are live microorganisms that produces beneficial effects in human gut. Probiotics can be taken as a dietary supplement. They prevent diarrhoea and help to reduce the symptoms of irritable bowel syndrome. Download the sample report at: Probiotics comprise of a variety of microorganisms belonging to the Lactobacillus and Bifidobacterium groups. The only yeast probiotic that has proven to be effective is Saccharomyces boulardii. According to researchers, probiotics are effective in
Niemann-Pick Disease Type C (NPC) Therapeutics Pipeline to Witness Significant G …
Niemann-Pick disease is divided into four main types: type A, type B, type C1, and type C2. These types are classified on the basis of genetic cause and signs and symptoms of the disease. NPC is identified as a rare genetic disorder in which the body is unable to transport cholesterol and lipids inside the cells. This causes accumulation of these substances within various tissues of the body. These substances

All 5 Releases

More Releases for PSP

Global Progressive Supranuclear Palsy Market Propelled by the Rising Incidences …
Market Overview Progressive supranuclear palsy (PSP) is an uncommon moderate condition that can create some issues with balance, development, vision, discourse, and swallowing. It is also known as the Steele-Richardson-Olszewski condition. It is caused because of expanding quantities of synapses getting harmed over the long run. Basically, it is an extraordinary brain issue that causes significant issues with walking, harmony, and eye advancements. The issue results from the breaking down of
Progressive Supranuclear Palsy (PSP) Market Latest Trends and Future Growth Stud …
Palsy is a class of neuro-degenerative disorders affecting many people worldwide. Frequently seen among the geriatric population, palsy is not necessarily endemic to older generation or a specific race, infact they have also been reported in much younger populations, although the reason may be different (trauma/abuse). Progressive supranuclear palsy is a type of palsy, specific to older populations, wherein certain sections of the brain die due to various, yet unknown
Discover the Growth of the Progressive Supranuclear Palsy (PSP) Market
Palsy is a class of neuro-degenerative disorders affecting many people worldwide. Frequently seen among the geriatric population, palsy is not necessarily endemic to older generation or a specific race, infact they have also been reported in much younger populations, although the reason may be different (trauma/abuse). Progressive supranuclear palsy is a type of palsy, specific to older populations, wherein certain sections of the brain die due to various, yet unknown
Membership Website Offers Unlimited PSP and Xbox 360 Game Downloads
Vancouver, BC – PSP and Xbox 360 gamers are able to download unlimited legal games from a membership website. The innovative web site at offers games for the Xbox 360, Play Station 2, PS2, PSP, Xbox, GameCube, and more. “We give gamers what they want – unlimited downloads,” said Cary Cross, owner of the web site. “These are complete games, not demos. We offer legal software from a list of hundreds
Sony PSP Movie Web Site Offers Unlimited Free Movie Downloads to Members
Chicago -- Capitalizing on the latest high-tech trend, a new web site is providing the owners of Sony PSP with something irresistible -- free PSP movie downloads. "We have given extensive study to this rapidly growing market. These are the same people who download music and games. They do not like to pay for downloads one at a time, so that is why we have created a membership site. They want
Unlimited Downloads: Members of Web Site Get Unlimited PSP Games and Movies
Chicago -- PSP owners can download an unlimited number of movies, TV shows, games, and music as a member of a new web site created just for them. Members pay a small, one-time fee at and then receive instant access to millions of downloads. The quality videos are available in HD and DVD. "We have every type of game available on our site, including the most popular action, strategy, role-playing, sports,