Vascular Disrupting Agents Market Competitive Landscape Analysis with Forecast by 2025
Vascular disrupting agents are of two types: small-molecule and ligand-directed vascular disrupting agents. Small-molecule vascular disrupting agents have been further classified into tubulin-binding agents and flavonoids. Tubulin binding agents act by selectively binding to the β-tubulin colchicine binding site, which weakens microtubules and leads to change in the 3-dimensional shape of endothelial cells. Endothelial cells interrupt the tumor blood vessel, thereby leading to necrosis of cancer cells within the tumor. Examples of tubulin-binding agents include combretastatin, crolibulin, verubulin, and fosbretabulin.
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The other type of small-molecule vascular disrupting agents are flavonoids, which promote localized release of the tumor necrosis factor TNFα from nearby activated macrophage cells. Examples of flavonoids include 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and icaritin/pexastimogene devacirepvec. Ligand-directed vascular disrupting agents primarily act by delivering toxic effects to tumor endothelium. The small-molecule vascular disrupting agents segment is expected to expand significantly during the forecast period, as a majority of molecules in the pipeline are small molecules. Additionally, high incidence and prevalence rate of cancer, increase in the demand for newer treatment options, and the large number of ongoing clinical trials boost the Vascular Disrupting Agents Market. However, unsatisfactory results of clinical trials and low availability of safety data restrain the vascular disrupting agents market.
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In terms of geography, the global vascular disrupting agents market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America leads the global market, followed by Europe. Growth of the market in North America is attributable to high incidence and prevalence rate of cancer, rise in the geriatric population, and increase in the demand for advance treatment options in the region. Asia Pacific is an emerging market for vascular disrupting agents, due to developing health care infrastructure, increasing patient awareness, and rising government expenditure on health care in the region. However, low awareness among patients, high cost of therapy, and lack of availability of treatment options are factors restraining the vascular disrupting agents market in regions such as Middle East & Africa and Latin America.
Major players operating in the global vascular disrupting agents market include Mateon Therapeutics, Immune Pharmaceuticals, Nereus Pharmaceuticals, Madrigal Pharmaceuticals, Inc., Celgene Corporation, Bionomics Ltd., and Lees Pharmaceutical Holdings.
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