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Cyclic Olefin Use in Primary Containers Positioned to Grow as Initial Deployments Yield Reliability Data

06-07-2017 12:56 PM CET | Health & Medicine

Press release from: Applied Market Data

(Nashua, NH) – Medical device manufacturers are gradually turning to new materials such as cyclic olefin polymers and copolymers (/COPs/COCs) for primary drug container applications. COCs and other new plastics offer high heat resistance and a low level of extractables and leachables, and are less permeable to water. Because of their inert surface and break resistance these syringes are considered suitable for use in the demanding area of cytostatics and biopharmaceutics. Because of the technology capabilities required to successfully qualify a new non-glass prefillable device, it’s not uncommon for container developers to partner with leading materials companies.

Cyclic olefins as alternatives to glass for prefilled formats are gaining attention because of the increasing prevalence of protein- and peptide-based drugs, which can adsorb or bind to the surface of glass syringes. These drugs are also more likely to be sensitive to leached components from glass. Olefins such as COC and COP are relatively inert materials that minimize leaching of container components. In packaging of nonbuffered water diluents, they eliminate the pH shift caused by alkali leaching from glass. COC and COP can also be processed to provide glasslike transparency for assisting users in checking drug levels, quality, and particulate concentrations. Because of their inert surface and break resistance these syringes are considered suitable for use in the demanding area of cytostatics and biopharmaceutics.

While most interest has focused on the inroads to mainstream parenteral drug delivery by COC/COPs and attempts to dislodge Type 1 Glass as the ‘gold standard’ for primary drug containers, much of the success of cyclic olefins in injectable devices has come in wearable devices. Plastic has a distinct advantage in this segment because of their ability to support delivery of drugs with high viscosities and/or large volumes.

The geographical center for the cyclic olefin market is in Asia, more specifically Japan, which is home to six of the ten largest cyclic olefin suppliers. Not surprisingly, Japan is the largest single market for COC/COP devices.

Much of the recent research in cyclic olefin drug containers has been in the area of multilayer vials and cartridges – devices that combine multiple material layers to provide additional features and functionality while eliminating some of the limitations of single material containers. As drug developers and their device partners pursue solutions to the hundreds of biological drugs currently in the pipeline, the degree of flexibility that designing in plastics provides is expected to lead to novel container approaches and allow cyclic olefins to gain credibility via actual user experience and reliability data, which in turn is expected to lead to more design wins.

These findings are contained in a comprehensive report researched and written by Applied Market Data. Cyclic Olefin Primary Drug Containers: Applications, Markets, Plyers and Outlook has been researched and written to provide market participants and stakeholders with a comprehensive analysis of the products, markets and competitors in this evolving market segment.

More information is available at www.appliedmarketdata.com


Source: Applied Market Data

About Applied Market Data

Applied Market Data is a technology consulting firm focused on the areas of technology strategy, product commercialization, venture development, and market research. We assist technology companies in achieving their business objectives through the creation of detailed development strategies, product commercialization programs, and comprehensive market and technology research and analysis. Our market research publications are designed, researched and written to provide timely and insightful information and data on focused market segments, with the aim of providing market participants with the essential knowledge to refine and execute their marketing plans and achieve their financial targets.

Contact:

Greg Stone
Applied Market Data
98 Amherst Street
Amherst, NH 03031 USA
Voice: 603-341-3073
grstone@appliedmarketdata.com
www.appliedmarketdata.com

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