Press release
MoBiTec Germany, Offers Blood Group Products Manufactured by Dextra, UK
Blood Groups
The discovery of the ABO blood typing system by Karl Landsteiner over 100 years ago and the subsequent elucidation of their carbohydrate structures by Walter Morgan were exceedingly important milestones in the progression of modern medicine. The ABO system is the most important of the many blood typing systems and is of the utmost importance in transfusion and transplantation medicine. If patients receive a transfusion of incompatible blood, an acute haemolytic reaction can occur, this can lead to death.
The blood group antigens are oligosaccharides expressed on the surface of red blood cells and are determined by the terminal saccharides. The biosynthesis is effected via the action of the A or B glycosyltransferase on the H antigen, to form the A or B glycan. The H antigen remains unmodified in individuals lacking either of these glycosyltransferases, resulting in an individual with blood type O. The expression of these antigens is not limited to red blood cells and also occurs on epithelial and other cells.
Blood groups are determined by the ABO gene, which encodes the glycosyltransferase which forms the A, B, and H antigens. The alleles for the A and B blood types show co-dominance, whilst the blood group O allele is recessive, giving rise to the familiar 4 ABO blood types.
The Dextra product range of free sugars is complemented by the capability to have these antigens produced as bioconjugates to a range of solid supports, proteins, and lipids.
Many of these items are hold in stock for immediate purchase from the catalog range. However welcome are also inquiries in regard to custom requirements across all the blood group product ranges.
About Dextra
Dextra was founded in 1989 in Reading (UK) to provide carbohydrate synthesis and analytical services for research use. Since then, the company has gained a worldwide reputation for the supply of rare sugars, oligosaccharides and chiral molecules for medical research, diagnostics and pharmaceutical applications.
The acquisition of Dextra by New Zealand Pharmaceuticals Ltd now provides customers with a fully integrated and seamless service, from lab scale product development at Dextra through to commercial manufacture at NZP’s licensed facilities in New Zealand.
About MoBiTec GmbH
MoBiTec GmbH (Goettingen, Germany) is a privately held company (founded in 1987) that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.
In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.
MoBiTec GmbH
Arne Schulz
Lotzestr. 22a
37083 Goettingen, Germany
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