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FerroFarRed - An Ion Indicator for the Specific Detection of Fe2+

12-11-2018 10:13 AM CET | Science & Education

Press release from: MoBiTec GmbH

Reaction Mechanism of FerroFarRed

Reaction Mechanism of FerroFarRed

Intracellular Fe2+ can react with hydrogen peroxide, thereby producing the hydroxyl radical, a reactive oxygen species (ROS). Excessive ROS causes oxidative stress, resulting in cancer and neurodegenerative diseases.

FerroFarRed (also known as SiRhoNox-1 or ER-SiRhoNox) is a fluorescent probe,manufactured by Goryo Chemical, Japan, distributed in Europe by MoBiTec GmbH, Germany. FerroFarRed specifically detects labile iron (II) ions (Fe2+) and is known to react with Fe2+ only, separately from other metal ions. Upon reaction with Fe2+ it irreversibly turns into a far-red fluorescent substance. FerroFarRed mainly localizes inside the endoplasmic reticulum (ER). It can also be used with a flow cytometer equipped with a red laser.

Features of FerroFarRed:

* Target: Labile iron (Fe2+)
* Cell Permeability: Yes
* Absmax:: 646 nm
* FLmax (nm): 662 nm
* Fluorescence: Irreversible
* Cytotoxicity: FerroFarRed shows almost no cytotoxicity at concentrations of up to 100 μM (~20 times that of generally used concentrations).

Goryo Chemical is a leading manufacturer of next generation fluorescent probes and research chemicals.

FerroFarRed and all other Goryo Chemical products can be ordered from MoBiTec:

Contact for more information and bulk pricing options.

About MoBiTec GmbH

MoBiTec GmbH (Goettingen, Germany) is a privately held company (founded in 1987) that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.

In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.

MoBiTec GmbH, Lotzestr. 22a
37083 Goettingen, Germany

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