Press release
Specificity and Quantification in Chimerism Analysis
Deliberate assortment of genetic markers is required, tailored product-design is mandatory Biotype Diagnostic offers a commercially available multiparameter analysis for specific chimerism analysisDresden, Germany, June 26, 2012 -- Chimerism analysis is compulsory to examine the therapeutic success of stem cell transplantation and to estimate the potential risk to suffer a relapse. Through this analysis, relative ratio of donor - and recipient - derived stem cells is quantitatively displayed and explicitly reveals the status of transplant engraftment. For this reason a deliberate and specific choice of the applied diagnostics is essential. Biotype Diagnostic developed a commercially available multiparameter analysis for specific chimerism analysis. This molecular application was validated by monitoring chimerism status of more than 200 related donor-recipient-pairs; a unique feature of that assays. Hence, this application meets all diagnostic requirements for a sensitive and informative chimerism analysis.
In general the predictive value of a multiparameter analysis relies on the sensitivity and the specificity of deployed components. These components also account for robustness and thus reproducibility of generated results. Therefore, the minute choice and accurate combination of parameters utilised is of vital interest if a reliable diagnostic should be established. The idea to compensate weaknesses of single parameters by inserting multiple other parameters is likewise misleading then the consumption that redundancy amongst single parameters could account for improved analytical value. A sound application to monitor chimerism requires strong components that generate as little background as possible and allow a clear, unambiguous differentiation of donor - and recipient - derived stem cells. Establishing such a diagnostic multiparameter analysis therefore asks for extensive bio-medical know-how and long lasting empirical value. Moreover, specific validation on relevant clinical samples is mandatory in order to test for specificity and significance.
Since most multiparameter analyses, applied for chimerism monitoring, have not specifically been tested for this medical area, this accurate test-system will be of high interest for clinical experts. Biotype is filling the market niche that has last for a long time by providing an expert solution for reliable and effective chimerism testing.
Mentype® Chimera® addresses 12 highly polymorphic genetic sequences that show balanced distribution within the population and generate only nominal background signal.
Contact:
Dr. Sophia Mersmann
Biotype Diagnostic GmbH
Moritzburger Weg 67
Dresden, Germany 01109
+49 351 8838 432
s.mersmann@biotype.de
http://www.biotype.de
Das Team der Biotype Diagnostic GmbH möchte sich herzlich für Ihren Besuch auf unserem Stand im Rahmen der ISHAM letzte Woche in Berlin bedanken. Die Gedanken, Fragen und Anregungen unserer Kunden und Interessenten waren uns sehr willkommen
Dr. Sophia Mersmann
Biotype Diagnostic GmbH
Moritzburger Weg 67
Dresden, Germany 01109
+49 351 8838 432
s.mersmann@biotype.de
http://www.biotype.de
This release was published on openPR.
Permanent link to this press release:
Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release Specificity and Quantification in Chimerism Analysis here
News-ID: 226781 • Views: …
More Releases from Biotype Diagnostic GmbH
New dynamics in monitoring diagnostics in leukemia
Dresden/Germany
Diagnosis leukemia and stem cell transplantation
The diagnosis "leukemia" for patients means to undergo several stressful therapeutic interventions. If chemotherapy is not effective, stem cell transplantation mostly is the last chance for healing. However, a sudden graft rejection or disease relapse can always occur despite the successful transfer of the hematopoietic stem cells from donor to recipient. Therefore, the regular quantitative assessment of the donor and recipient cell-portion in the blood…
Can quantitative chimerism monitoring serve as surrogate marker to predict clini …
A promising method indicates success
Allogeneic stem cell transplantation (HSCT) is an effective therapy for hematopoietic disorders such as Acute Myeloid Leukemia (AML) or the Myelodysplastic Syndrome (MDS). However, imminent relapse remains a serious problem. Routinely, monitoring of minimal residual disease (MRD) by diseases-specific markers such as FLT3, NPM1, BCR-ABL, AML-ETO and others is performed to signify threatening relapse as early as possible. However, a high number of patients lack…
Summer is Holiday Time and Fungal Infections are Advancing Fast
Don’t miss out. A multiparameter PCR-analysis for differential diagnostics of dermatophytosis (also ringworm, athletes foot) will become available as full in-vitro-diagnostics.
Dresden, Germany, July 18, 2012 -- Today, Biotype set the 1st of August as date, on which its latest product, Mentype® MycoDermQS, will be launched as full In-Vitro Diagnostics (IVD). On the recently held 18th ISHAM in Berlin, Germany, Biotype has initially introduced its multiparameter analysis. This product represents the…
More Releases for Dresden
A popular IT expert from Dresden develops start-up ideas
Timo Grosche, an IT expert from Dresden, develops ideas with great passion and uses them to found start-ups. In his young career he has already implemented many such ideas. As a result, he has become a popular expert on start-up topics and on technical subjects. He invests not only his knowledge and passion in these projects, but also his own money. The social aspect is always important to him. The…
Leipzig, Dresden and Berlin score top spots in city ranking
Among Germany’s five most auspicious cities, three are located in the eastern part of the country – Leipzig, Dresden and Berlin. Or so the outcome of the latest city ranking by the HWWI Hamburg Institute of International Economics and by the private bank Berenberg Bank suggests. The ranking compares the competition- and location-related factors of the country’s 30 largest cities. The last ranking dates back to 2015. Munich took the…
New Opening: Swissôtel Dresden Am Schloss
Business and leisure travellers alike from all around the world can look forward to the soon-to-be-opened Swissôtel Dresden Am Schloss. On the 1st of April 2012, Swissôtel Hotels & Resorts opens its fourth hotel in Germany, offering Swiss hospitality in a modern atmosphere as well as first class quality combined with personal service, in the very centre of Saxony’s capital.
Situated opposite the Residence Castle and boasting 214 Swiss Advantage…
A true Highlight. Bülow Palais Dresden.
Dresden, August 2010 / Hotel Bülow Palais in Dresden which recently opened its doors is a true highlight. Throughout the hotel lavish fabrics and high quality materials abound. The use of design objects and modern art was perfectly balanced. KMD supplied fine onyx to the ladies and men’s rooms, as well as the Palais Bar. The backlit Two-Lux® vanity tops and bar cladding in Onice Pink, Onice Orange and Onice…
Dresden Music Festival
May 20 – June 7, 2009 - The Dresden Music Festival has a distinguished history and an established position within Germany’s festival landscape. To achieve his programmatic goals Jan Vogler, the new Intendant, will rely on the exceptionally high artistic profiles of the Festival’s guest artists and his own focused dramaturgical plans. This year’s motto »New World« stresses the visionary aspect of Dresden as a city of understanding, of the…
IonGate at the SBS Symposium Europe in Dresden
Frankfurt/Main (Germany), 6th June 2008. IonGate Biosciences GmbH will present relevant application fields for the proprietary SURFE2R Technology (SURFace Electrogenic Event Reader) at the SBS Symposium “Label Free Technologies in Drug Discovery” in Dresden, Germany. The meeting is being held at the international congress center on June 10 – 11.
Dr. Henning Vollert will explain the advantages of the cell- and label-free technology in comparison to the more conventional patch clamp…
