Immunology: Distinctive features of autoantibodies in and out of the context of overt autoimmunity
"Autoantibodies in healthy individuals occured in lower concentration and lower avidity as compared to those in patients with rheumatic diseases. Autoantibodies in healthy individuals tended to be represented mostly by a single immunoglobulin isotype while autoantibodies in patients with SARD tended to occur as two or three isotypes. Finally, patients with SARD targeted autoantigens that are not usually targeted by autoantibodies in healthy individuals and vice-versa.
However, disease-specific autoantibodies frequently antedate the clinical onset of the respective disease... The pieces of evidence suggest a possible model of autoimmunity continuum with a gradual shift in several features of the humoral autoimmune response spanning healthy individuals, individuals with disease-specific autoantibodies at the pre-clinical stages of autoimmunity, and patients with overt autoimmune diseases.
Understanding the immunological mechanisms underlying the modifications of the humoral autoimmune response across this spectrum may help the discovery of effective measures for the prevention and management of this class of diseases ..."
Karsten Conrad et al. (Eds.) From Prediction to Prevention of Autoimmune Diseases. Pabst, Lengerich/Berlin, 728 pages, ISBN 978-3-89967-735-5
Pabst Science Publishers (Lengerich/Westfalia, Germany) is publishing ten psychological and nine medical journals; furthermore, Pabst is publishing more than hundred psychological and medical books per year – partly specialized scientific literature, partly specialist literature written for laypeople.
Pabst Science Publishers
This release was published on openPR.
Permanent link to this press release:
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release Immunology: Distinctive features of autoantibodies in and out of the context of overt autoimmunity here
News-ID: 208633 • Views: 1540
More Releases from Pabst Science Publishers
Health literacy: How to improve health behaviors
Health literacy is defined as "people´s knowledge, motivation and competences to access, understand, appraise and apply information to make judgements and take decisions in everyday life healthcare concerning disease prevention and health promotion to maintain and improve quality of life during the life course." In a new volume Anne-Kathrin Mayer and colleagues shed light on the concept of health literacy from different disciplines: psychology, educational sciences, health sciences and
Health literacy: how to improve the advantages and to reduce the risks
The new volume "Health literacy across the lifespan" stresses the importance of health literacy for changing multiple health-risk-factors. Anne-Kathrin Mayer and colleagues shed light on a concept from different disciplines: psychology, educational sciences, health sciences and public health, communication sciences, and information sciences. It is undisputed that health is strongly influenced by individual efforts aimed at the promotion of health and the prevention of illness or recovery from diseases. These
Directed deceased donation: beyond the impartial allocation system
"Within a pluralistic account of morality, partial values have a merit of their own and should be assessed in their own terms. These values are extremely relevant in the field of organ transplantation, but are misunderstood at a political level where partiality is put at par with injustice, and where fairness is exclusively taken as impartial justice." Dr. Medard Hilhorst (Erasmus Medical University Rotterdam) argues "that partial values are fundamental
Transplantation: Prisoners are killed for their organs in China
Transplantation: China is the only country in the world systematically using organs from prisoners for transplantation, Professor Huige Li reports. For over 40 years, executed prisoners were used as the main organ source in China. It´s a profitable international business. A number of Chinese Hospitals claimed that they could provide liver transplants in the time range between 3 to 30 days. The report appeared in "Ethical, Legal and Psychosocial Aspects
More Releases for Lengerich
Factor V leiden and prothrombin G20210A mutations may predispose for cerebral in …
A recent age- and sex-matched paired case-control study comparing patients suffering from cerebral infarction with and without patent foramen ovale (PFO) revealed that the occurence of factor V leiden and, to a lesser extent, of prothrombin G20210 A mutation is a clinically relevant risk for the development of cerebral infarction in association with PFO. Berhard Stephan and his team at the University Hospitals of Saarland, Homburg (Germany) studied a total of
Reference-Book: Quality Assurance and Improvement in the Field of Hygiene in Dia …
The "Guideline for Applied Hygiene in Dialysis Units" represents a reference book which links hygiene with quality management and gives answers to all relevant practical questions. The advantages for nephrologists and their staff are relevant: Streamlining and optimising the process, prevention of mistakes and their resulting costs as well as the improvement of treatment safety. The areas of responsibility become clearer. Documented processes ease the tractability as well as the
Chronic fatigue syndrome and sick building syndrome may be autoimmune diseases
"The role of environmental factors, such as those entailing an immune adjuvant activity, is well established in the pathogenesis of immune mediated diseases. It appears that the activation of the immune system by adjuvants either natural (i.e. infectious agents) or pharmaceutical ones (i.e., vaccines containing alum or silicone), can trigger manifestations of autoimmunity or even autoimmune diseases", Yehuda Shoenfeld and Nancy Agmon-Levin (Tel-Hashomer, Israel) report. "However, these manifestations are
Greece: Citizens View Corruption as a Normal Way of Getting Things Done
"There are a number of ambivalences characterising perceptions of corruption in Greece", PD Dr. Giannakopoulos (University Konstanz/Germany) reports. He found in his EU-research-project "Crime and Culture": "There are strong beliefs about corruption being highly widespread and diffused in the social fabric, because: - Corruption should indeed be considered as a dominant social attitude and acceptable behaviour, or even as one of the main evils in modern Greek society (social disease); - General
Cross-Cultural Study of Infants and Toddlers: Developmental Stages According to …
"Cross-cultural research has been particularly useful in demonstrating the universality of cognitive stages during child development. For instance, the sequence and timing of Piagetian sensorimotor learning in infancy appears quite similar across cultures", Professor Dr. Alice Sterling Honig (Syracuse University, USA) reports. "Despite the gradual nature of continuity in early development, cross-cultural studies indicate that there exist discontinuities in the developmental milestones achieved in the early years. For example, the
An appropriate dialysis treatment provides the unique opportunity to slow down c …
"Cardiac disease is the major cause of death in dialysis patients, accounting for half of the total mortality. When routinely assessed by echocardiography, the proportion of patients with abnormal dimensions of cardiac compartments is even higher. When chronic kidney disease progresses, cardiovscular damage starts to develop and may already be quite severe before dialysis is started," Branko Braam and colleagues report in their textbook "Hypertension and Cardivascular Aspects of Dialysis