Doxorubicin Market to Witness Widespread Expansion During 2016 - 2024

It is less commonly used in treatment of squamous cell carcinomas of head and neck, cervix and vagina, carcinomas of testes and prostate. The drug kills the cancerous cells in several ways including intercalation between DNA pairs thereby preventing replication of cancer cells, DNA strand breakage and inhibition with enzyme topoisomerase II. Doxorubicin is marketed either in the powdered or in solution form and is administered intravenously every 21 to 28 days. However, the treatment depends upon the type of cancer being treated, the types of other drugs that are taken during the treatment and how well the body response to the medicine. The drug is sometimes given as a continuous infusion wherein the drug is infused slowly into the patient’s body.

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Global doxorubicin market is expected to witness upsurge in its revenue over the forecast period attributed to growing prevalence of cancer worldwide. WHO estimates that cancer prevalence is expected to increase at an estimated rate of 50% by 2050. Furthermore, increasing use of drug in the treatment of ovary cancer is further expected to increase the sales of the doxorubicin over the forecast period. The drug is also known to have high treatment efficacy in patients with AIDS-related Kaposi’s sarcoma after failure of prior systemic chemotherapy.

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However, conventional doxorubicin treatment imposes several side effects such as nausea and vomiting that may last 24–48 hours after treatment, hair loss, myelosuppression, loss of appetite, diarrhea, localized swelling etc. Therefore, the need for development of doxorubicin with liposomal formulation arose improving therapeutic index of conventional doxorubicin. This strategy resulted in preferential accumulation of doxorubicin within the cancerous cell in order to maximize the drug efficacy and minimize toxicity, thus fueling the doxorubicin market growth in the near future.

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One of the most common and prevailing side effect of doxorubicin is cardiomyopathy with an estimated incidence of 4% at a dose of 500–550 mg/m², subsequently leading to congestive heart failure. The rate of cardiomyopathy reaches to 36% when the dose exceeds 600 mg/m². This may lead to introduction of drugs with lesser side effects replacing the doxorubicin in the future. However, ongoing shortages of the drug has also affected the revenues of the doxorubicin market contently.

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