Exocrine Pancreatic Insufficiency Therapeutics Market Size in the 7MM is anticipated to increase at a significant CAGR by 2034, estimates DelveInsight

DelveInsight's "Exocrine Pancreatic Insufficiency Market Insight, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of exocrine pancreatic insufficiency, historical and forecasted epidemiology as well as the exocrine pancreatic insufficiency market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

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Key Takeaways from the Exocrine Pancreatic Insufficiency Market Report

• In the 7MM, the highest Exocrine Pancreatic Insufficiency Prevalent Cases were observed in the United States in 2023 and are expected to increase during the forecast period (2024-2034).
• Several indications such as mild acute pancreatitis, moderate to severe acute pancreatitis, chronic pancreatitis, and a few others form the major causative agents for exocrine pancreatic insufficiency in the United States.
• Among EU4 and the UK, Spain has consistently shown the lowest treated cases.
Among all the exocrine pancreatic insufficiency patients, the highest prevalent cases of causative indications were Type 2 diabetes mellitus in the 7MM.
• The leading Exocrine Pancreatic Insufficiency Companies such as AbbVie, Nestle, Digestive Care, Inc., AzurRx BioPharma, Inc., Abbott, Orlando Health, Inc., Chiesi Farmaceutici, and many others.
• Promising Exocrine Pancreatic Insufficiency Therapies such as PERTZYE (pancrelipase), CREON (pancrelipase)/LIPACREON, ZENPEP (pancrelipase), .PANCREAZE (pancrelipase), VIOKACE (pancrelipase), and others.

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Exocrine Pancreatic Insufficiency Epidemiology Insights

• Exocrine Pancreatic Insufficiency Prevalence in the US
• Exocrine Pancreatic Insufficiency Prevalence of Causative Indications
• Exocrine Pancreatic Insufficiency Diagnosed and Treatable Cases

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Exocrine Pancreatic Insufficiency Treatment Market Landscape

The Exocrine Pancreatic Insufficiency treatment primarily focuses on supplementing the deficient pancreatic enzymes and managing the underlying causes to improve digestion and nutrient absorption. Effective management of EPI involves a combination of enzyme replacement therapy, dietary modifications, addressing underlying causes, and lifestyle changes. These treatments aim to improve digestive function, enhance nutrient absorption, and alleviate symptoms to improve the patient's quality of life.

Exocrine Pancreatic Insufficiency Market Factors

Key factors contributing to the positive Exocrine Pancreatic Insufficiency market growth include the increasing prevalence of conditions like cystic fibrosis and chronic pancreatitis, advancements in pancreatic enzyme replacement therapy (PERT), and rising awareness and early diagnosis of EPI. Additionally, an aging population and increased healthcare expenditure enhance market demand. Regulatory approvals and investment in research and development also drive Exocrine Pancreatic Insufficiency market growth.

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Exocrine Pancreatic Insufficiency Marketed Drugs

• PERTZYE: Digestive Care

PERTZYE is a pancreatic enzyme preparation consisting of pancrelipase, an extract derived from porcine pancreatic glands. Pancrelipase contains multiple enzyme classes, including porcine-derived lipases, proteases, and amylases. In July 2012, PERTZYE was approved by the US FDA in patients with exocrine pancreatic insufficiency due to cystic fibrosis or other conditions. Further, in October 2016, the drug received FDA approval for an infant-specific dose of PERTZYE in a 4,000 USP lipase units capsule. The new capsule strength will enable guideline-recommended dosing and administration of PERTZYE for infants (up to 12 months) with exocrine pancreatic insufficiency.

• CREON: Solvay Pharmaceuticals

It is a pancreatic enzyme preparation consisting of a combination of lipases, proteases, and amylases and is an extract derived from porcine pancreatic glands. In May 2013, CREON received the US FDA approval for the commercial availability of a new, higher-dose variant of CREON delayed-release capsules to treat patients with EPI due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions. In April 2011, CREON was approved in Japan under the brand name LIPACREON.

Exocrine Pancreatic Insufficiency Emerging Drugs

• FW-EPI (adrulipase): First Wave Biopharma

FW-EPI is a recombinant lipase enzyme administered as an oral, non-systemic biologic capsule for the treatment of exocrine pancreatic insufficiency associated with cystic fibrosis and chronic pancreatitis. It is derived from the Yarrowia lipolytica yeast lipase and is designed to break up fat molecules in the digestive tract of exocrine pancreatic insufficiency patients so that they can be absorbed as nutrients. In developing adrulipase, First Wave is seeking to provide cystic fibrosis and chronic pancreatitis patients with a safe and effective therapy to control exocrine pancreatic insufficiency that is non-animal derived, offers the potential to dramatically reduce their daily pill burden, and can be manufactured on demand at high volumes safely and with a high degree of reproducibility. First Wave is developing adrulipase as a monotherapy and in combination with PERT.

• ANG003: Anagram Therapeutics

ANG003 is a novel broadspectrum orally delivered enzyme replacement therapy for the treatment of malabsorption and exocrine pancreatic insufficiency. The drug is currently in Phase I trial for adult subjects with CF-related EPI.

Exocrine Pancreatic Insufficiency Market Outlook

The treatment landscape of exocrine pancreatic insufficiency majorly includes pancreatic enzyme replacement therapy, lifestyle modifications (e.g., avoidance of fatty foods, limitation of alcohol intake, cessation of smoking, and consumption of a well-balanced diet), and vitamin supplementation (primarily the fat-soluble vitamins A, D, E, and K). PERT is the first-line therapeutic mainstay that is prescribed to patients.
The pancreatic enzyme products used for PERT are extracts of porcine pancreas that contain all three pancreatic enzymes (i.e., amylase, protease, and lipase) in varying proportions. However, it is lipase that plays a paramount role in therapy. Pharmacological therapies are the mainstay treatment option followed by patients with exocrine pancreatic insufficiency. The market of exocrine pancreatic insufficiency includes the use of the drugs either as monotherapy and are not interchangeable. There are several approved drugs in the market of different classes. The following PEPs have been approved by the FDA for the treatment of maldigestion in patients whose bodies do not produce sufficient pancreatic enzymes: CREON, PANCREAZE, PERTZYE, VIOKACE, and ZENPEP. Some medicines are needed to treat pain.

Scope of the Exocrine Pancreatic Insufficiency Market Report

• Coverage- 7MM
• Study Period- 2020-2034
• Exocrine Pancreatic Insufficiency Companies- AbbVie, Nestle, Digestive Care, Inc., AzurRx BioPharma, Inc., Abbott, Orlando Health, Inc., Chiesi Farmaceutici, and many others.
• Exocrine Pancreatic Insufficiency Therapies- PERTZYE (pancrelipase), CREON (pancrelipase)/LIPACREON, ZENPEP (pancrelipase), .PANCREAZE (pancrelipase), VIOKACE (pancrelipase), and others.
• Exocrine Pancreatic Insufficiency Market Dynamics: Exocrine Pancreatic Insufficiency Market drivers and Exocrine Pancreatic Insufficiency Market Barriers
• Exocrine Pancreatic Insufficiency Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
Exocrine Pancreatic Insufficiency Unmet Needs, KOL's views, Analyst's views, Exocrine Pancreatic Insufficiency Market Access and Reimbursement

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Table of Content

1. Key Insights
2. Report Introduction
3. Executive Summary
4. Exocrine Pancreatic Insufficiency (EPI) Market Overview at a Glance
5. Key Events
6. Epidemiology and Market Forecast Methodology
7. Disease Background and Overview
8. Epidemiology and Patient Population
9. Patient Journey
10. Marketed Products
11. Emerging Therapies
12 Exocrine Pancreatic Insufficiency: Seven Major Market Analysis
13. Unmet Needs
14. SWOT Analysis
15. KOL Views
16. Market Access and Reimbursement
17. Appendix
18. DelveInsight Capabilities
19. Disclaimer

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Website: https://www.delveinsight.com/

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