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United States Propel SGLT-2 Inhibitors Market at 7.1% CAGR on Expanding Cardiorenal Indications
SGLT-2 Inhibitors Market
As per DataM Intelligence research report "SGLT-2 Inhibitors Market reached US$ 17.95 billion in 2024 and is expected to reach US$ 32.16 billion by 2033, growing with a CAGR of 7.1% from 2025 to 2033." Rising prevalence of type 2 diabetes, expanding indications for cardiorenal protection (heart failure and chronic kidney disease), new product approvals, and increasing adoption in emerging markets are fueling growth in the SGLT-2 inhibitors market.
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Japan: Recent Industry Developments
✅ In 2025, Mitsubishi Tanabe Pharma launched CANALIA, the first once-daily oral combination of a DPP-4 inhibitor with an SGLT2 inhibitor, enhancing treatment options for type 2 diabetes.
✅ In October 2025, Mitsubishi Tanabe introduced innovative combination therapies in Japan, aligning with national diabetes management programs.
✅ In 2025, Japan saw continued adoption of Japan-specific SGLT2 inhibitors like ipragliflozin (Suglat), supporting precision medicine for cardiometabolic profiles in the aging population.
United States: Recent Industry Developments
✅ In November 2025, Boehringer Ingelheim and Eli Lilly advanced Jardiance expansions with new data reinforcing cardiorenal protection, driving prescription growth.
✅ In September 2025, U.S. HHS initiatives and guideline updates positioned SGLT-2 inhibitors as preferred therapies for comorbid conditions, boosting adoption.
✅ In 2025, positive trial results for INPEFA (sotagliflozin) demonstrated a 23% reduction in heart attacks, strokes, and cardiovascular mortality in heart failure patients.
SGLT-2 Inhibitors Market: Drivers
The SGLT-2 inhibitors market is driven by the rising prevalence of type 2 diabetes, increasing research and development activities, and new product launches. Expanding indications beyond glycemic control to include heart failure and chronic kidney disease (CKD), proven cardiorenal benefits, guideline recommendations, and growing market access in emerging countries further accelerate adoption. Rising awareness of multi-organ protection and supportive regulatory approvals sustain momentum amid the global burden of cardiometabolic diseases.
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SGLT-2 Inhibitors Market: Major Players
TheracosBio, LLC, Johnson & Johnson Services, Inc., AstraZeneca, Boehringer Ingelheim International GmbH., Eli Lilly and Company., Pfizer Inc., Merck & Co., Inc., Lexicon Pharmaceuticals, Inc.
Segment Covered in the SGLT-2 Inhibitors Market:
By Drug Type
Bexagliflozin, Canagliflozin, Dapagliflozin, Empagliflozin, Ertugliflozin, Sotagliflozin.
By Indication
Type-2 Diabetes, Chronic Kidney Disease (CKD), Heart Failure.
By Distribution Channel
Hospital Pharmacies, Retail Pharmacies, Online Pharmacies.
Regional Analysis
North America - Dominant Share
North America leads with a significant share of 41.9% in 2024, driven by high diabetes prevalence, advanced healthcare infrastructure, early regulatory approvals, and strong adoption for cardiorenal indications.
Asia Pacific - Fastest-Growing
Asia Pacific expands rapidly with the highest CAGR, fueled by rising diabetes cases, urbanization, improving healthcare access, and local innovations.
Europe - Significant Share
Europe grows with emphasis on evidence-based guidelines and cardiorenal protection benefits.
South America - Gradual Growth
South America shows steady progress amid increasing diabetes awareness and healthcare investments.
Middle East & Africa - Emerging Growth
Middle East & Africa rises with growing chronic disease burden and expanding pharmaceutical access.
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