Press release
Overt Hepatic Encephalopathy Market is projected to reach nearly USD 3.8 billion by 2034, registering a CAGR of about 8%
Overt Hepatic Encephalopathy Market
The Overt Hepatic Encephalopathy Market is expanding due to rising global liver disease prevalence, increasing cirrhosis cases, and the growing need for effective long-term management therapies. The market was valued at around USD 1.7 billion in 2024 and is projected to reach nearly USD 3.8 billion by 2034, registering a CAGR of about 8%. Key growth factors include the increasing adoption of rifaximin therapy, improved diagnostic awareness, and advancements in liver disease management.
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Key Market Drivers
• Rising incidence of chronic liver disease, cirrhosis, hepatitis B & C, alcoholic liver disease, and NASH-related liver damage.
• Growing acceptance of rifaximin, lactulose, and combination approaches for preventing HE recurrence.
• Increasing hospitalization rates and need for long-term management in recurrent HE patients.
• Improved diagnostic and monitoring processes in tertiary care hospitals.
Challenges
• Underdiagnosis and delayed identification of early-stage symptoms.
• High treatment costs for long-term rifaximin therapy.
• Limited awareness in emerging markets and variability in liver disease management protocols.
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Market Segmentation
By Drug Type
• Rifaximin
• Lactulose
• Neomycin
• Metronidazole
• Combination therapies
By Route of Administration
• Oral
• Injectable
By Distribution Channel
• Hospital pharmacies
• Retail pharmacies
• Online pharmacies
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Regional Insights
• North America remains the leading market due to high cirrhosis prevalence, strong healthcare infrastructure, and strong adoption of rifaximin.
• Europe demonstrates steady demand supported by structured liver disease management programs.
• Asia-Pacific is expected to grow rapidly due to rising hepatitis-related liver complications and expanding healthcare access.
Key Companies
Salix Pharmaceuticals, Bausch Health, Ferring Pharmaceuticals, Cosmo Pharmaceuticals, Lupin, Abbott, Takeda, Fresenius Kabi, AbbVie, Dr. Reddy's Laboratories.
Future Outlook
The market will continue to grow as hospitals increasingly adopt standardized HE treatment pathways, prescription rates for rifaximin rise, and liver disease incidence continues upward globally. Combination therapies targeting ammonia reduction and gut microbiome modulation represent emerging opportunities for the next decade.
This report is also available in the following languages : Japanese (顕性肝性脳症市場), Korean (명백한 간성 뇌병증 시장), Chinese (显性肝性脑病市场), French (Marché de l'encéphalopathie hépatique manifeste), German (Markt für manifeste hepatische Enzephalopathie), and Italian (Mercato dell'encefalopatia epatica manifesta), etc.
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