Overt Hepatic Encephalopathy Treatment Market Size, Share, Industry, Forecast and Outlook (2023-2030)

Global Overt Hepatic Encephalopathy Treatment Market Sees Remarkable Growth in 2022 and Projects Impressive CAGR
In the year 2022, the global overt hepatic encephalopathy treatment market achieved a valuation of US$ YY billion, with expectations to reach US$ YY billion by 2030. The market is poised to experience a robust Compound Annual Growth Rate (CAGR) of YY% throughout the forecast period from 2023 to 2030.
The global overt hepatic encephalopathy treatment market has undergone significant growth and transformative changes, influenced by various pivotal factors. Overt hepatic encephalopathy, characterized by symptomatic impairment of normal brain function due to hepatic failure and/or portosystemic shunting, impacts approximately 40% of cirrhotic patients during their therapeutic journey, with initial episodes often signaling recurrence.
Government investments and research initiatives, particularly in emerging economies, continue to drive the adoption of cutting-edge medications such as laxatives and antibiotics, propelling the global overt hepatic encephalopathy treatment market. Numerous researchers are actively developing these innovative treatments, which are currently undergoing clinical trials.
Key Insights:
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Driving Forces and Constraints:
Boosting Funding and Acquisitions: Developed economies are witnessing rapid growth in healthcare sectors, driven by substantial investments, high-income levels, and infrastructure development. Several countries are experiencing surging demand for overt hepatic encephalopathy treatment, resulting from increasing research activities. Collaborations, acquisitions, and product launches enhanced by technological advancements between different countries are pivotal drivers of market growth.
For example, on March 28, 2023, Umecrine Cognition secured SEK 31.6 million in fresh funding to advance its medication development initiatives. Umecrine Cognition's innovative approach in developing medicines for cognitive disorders, with golexanolone as its advanced medication candidate for hepatic encephalopathy (HE) and primary biliary cholangitis (PBC) treatment, is set to compensate for impaired brain function and address symptoms such as severe fatigue, difficulty concentrating, and poor motor coordination, common in severe brain diseases.

Moreover, the heightened adoption of novel technology, coupled with extensive research for development purposes, alongside the escalating cases of overt hepatic encephalopathy and ongoing research into innovative treatments, will significantly contribute to market growth.
Consideration of Side Effects: In the context of overt hepatic encephalopathy medications, rifaximin, a common antibiotic, is generally well-tolerated due to its non-systemic absorption. Controlled trials reported low dropout rates for adverse events for both rifaximin and placebo (0.4%). Infrequent side effects include anorexia, diarrhea, taste loss, and nasal passage discomfort. Some rifaximin patients may experience side effects such as nausea, stomach upset, fatigue, dizziness, peripheral edema, and muscle spasms.
Prolonged usage has been associated with bacterial or fungal super-infections. Despite extensive usage, minimal evidence suggests that rifaximin elevates serum enzyme levels or leads to clinically evident liver damage.

Segment Analysis:
The global overt hepatic encephalopathy treatment market is segmented based on medications, route of administration, distribution channels, and regions. The antibiotics segment holds a substantial market share of approximately 39%.
Rifaximin, a non-absorbable oral antibiotic, is extensively utilized for the treatment of overt hepatic encephalopathy in adults, as well as the management of irritable bowel syndrome-associated diarrhea and travelers' diarrhea caused by noninvasive Escherichia coli strains. Rifaximin demonstrates efficacy against a broad spectrum of anaerobic and aerobic gram-positive and gram-negative bacteria.
Owing to its non-absorbable nature, rifaximin accumulates to high concentrations in the gastrointestinal tract, facilitating the treatment of various gastrointestinal diseases without inducing systemic side effects. Bacterial resistance to rifaximin is sporadic in extra-intestinal microorganisms.

On June 22, 2023, ASKA Pharmaceutical Co., Ltd., a wholly-owned subsidiary of ASKA Pharmaceutical Holdings Co., Ltd., submitted an application for a partial change to the production and distribution authorization for RIFXIMA TABLETS (rifaximin) with an intention to increase the dosage and administration for pediatric patients in the treatment of hyperammonemia in hepatic encephalopathy.
Regional Dominance:

North America, accounting for roughly 35% of the market share in 2022, offers manufacturers significant growth prospects in overt hepatic encephalopathy treatment. The region hosts numerous producers and suppliers, and its rapid economic growth has led to an expansion in industrial production, driving the demand for overt hepatic encephalopathy treatment.

Increasing healthcare expenditure, burgeoning research endeavors, technological advancements, the proliferation of biopharmaceutical and biotechnology businesses, and the growing awareness of newly approved medications substantiate North America's dominant position in the global market.

COVID-19 Impact Analysis:
The advent of the COVID-19 pandemic in early 2020 presented unprecedented challenges to industries worldwide, including the global overt hepatic encephalopathy treatment market. As countries implemented lockdowns, supply chain disruptions, and economic slowdowns, the pharmaceutical sector, a substantial consumer of various medicines, faced significant setbacks.
Major medical and pharmaceutical industries shifted their focus toward managing the pandemic, resulting in a decrease in the demand for overt hepatic encephalopathy treatment. However, several research studies have resumed, and companies have recommenced trials for their products. Overall, the impact of the pandemic on the global overt hepatic encephalopathy treatment market is anticipated to be relatively moderate, with the market poised to maintain steady growth due to the ongoing need for innovative treatments.

Key Developments:
On June 19, 2023, Bausch Health Companies Inc. and Salix Pharmaceuticals selected XIFAXAN (rifaximin) data for inclusion in the Cirrhosis and its consequences session at the 2023 European Association for the Study of the Liver (EASL) Congress.
On June 30, 2021, Axcella initiated a Phase 2 clinical trial for AXA1665, its multi-targeted oral candidate designed to reduce the risk of persistent overt hepatic encephalopathy (OHE).

Competitive Landscape:
Prominent global players in the market encompass Axcella Therapeutics, COSMO PHARMACEUTICALS, Umecrine Cognition AB, Salix Pharmaceuticals (Bausch Health Companies Inc.), ASKA Pharmaceutical Holdings Co., Ltd., Lupin, Norgine, Teva Pharmaceutical Industries Ltd., Fresenius Kabi Austria GmbH, and Fengchen Group

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