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Fragment-Based Drug Discovery Market to Reach USD 3.2 Billion by 2035, Driven by Structural Biology Advancements and Expansion of Fragment Libraries | TMR

Fragment-Based Drug Discovery Market

Fragment-Based Drug Discovery Market

The global Fragment-based Drug Discovery (FBDD) Market is set for robust growth, projected to expand from US$ 1.1 billion in 2024 to US$ 3.2 billion by 2035, registering a strong CAGR of 10.6%, according to the latest market analysis. Increasing adoption of fragment-based techniques in drug design, the emergence of innovative fragment libraries, and expanding applications in oncology and central nervous system (CNS) disorders are key forces propelling the market forward.

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FBDD Gains Momentum as Biopharma Refocuses on Novel Targets
As the biopharmaceutical sector faces mounting pressure to replenish pipelines amid rising incidences of oncology, immunology, and CNS diseases, fragment-based drug discovery has emerged as a preferred strategic approach. Unlike traditional high-throughput screening, FBDD utilizes low-molecular-weight chemical fragments that bind effectively to protein targets, even with weak affinities. This methodology enables the identification of novel chemical starting points, particularly in challenging targets such as protein-protein interactions and allosteric sites.

"Fragment-based drug discovery is redefining early-stage research by offering a more efficient route to first-in-class and best-in-class therapies," stated an industry analyst. "The combination of biophysical screening, computational chemistry, and advanced structural biology tools has made FBDD a cornerstone for innovative drug design."

Technological Innovations Accelerate Discovery and Validation
The widespread availability of high-field Nuclear Magnetic Resonance (NMR), X-Ray crystallography, and Cryo-Electron Microscopy (cryo-EM) has significantly improved hit confirmation, structure-based optimization, and binding analysis. These technologies are now routinely integrated into discovery workflows by both large pharmaceutical firms and specialized Contract Research Organizations (CROs).

Data integration platforms are also transforming decision-making in FBDD. Enterprise-level data lakes combining structure-activity relationship (SAR), biophysics, and pharmacology data are streamlining the design-make-test-analyze cycle. This convergence of disciplines accelerates lead optimization and improves ADME (Absorption, Distribution, Metabolism, and Excretion) profiling at earlier stages.

Fragment Libraries and AI Integration Fuel Market Expansion
A major driver of the global FBDD market is the evolution of fragment libraries. Modern libraries are increasingly diverse and structurally rich, incorporating scaffolds optimized for drug-likeness and chemical diversity. Specialized collections - such as covalent fragment libraries, RNA-targeted fragments, and AI-designed libraries - are expanding FBDD's reach into previously undruggable targets.

The integration of artificial intelligence and machine learning for virtual fragment screening is also reshaping the discovery process. Predictive modeling and physics-informed scoring approaches, including free-energy perturbation and water thermodynamics, are improving hit prioritization and fragment elaboration.

Biophysical Techniques Dominate the Technology Landscape
The biophysical techniques segment continues to lead the global FBDD market due to its superior sensitivity and reproducibility. Technologies such as NMR, Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), and Mass Spectrometry provide detailed insights into fragment binding kinetics and thermodynamics. These methods remain essential in confirming fragment hits and guiding rapid optimization toward potent lead compounds.

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North America Leads Global Adoption
North America held the dominant share of the global FBDD market in 2024, supported by a concentration of advanced research infrastructure, pharmaceutical leaders, and biotechnology startups. The region benefits from substantial R&D funding, strong CRO networks, and a regulatory framework that encourages innovation in early drug discovery.

Prominent U.S. and Canadian research institutions continue to collaborate with CROs and technology vendors to accelerate FBDD workflows, further solidifying the region's leadership in fragment-based innovation.

Competitive Landscape and Strategic Collaborations
Leading market participants include Thermo Fisher Scientific Inc., Astex Pharmaceuticals, Domainex, Beactica Therapeutics AB, Charles River Laboratories, Evotec International GmbH, Sprint Bioscience, Structure Based Design Inc., Sygnature Discovery Ltd., Malvern Panalytical Ltd., Vernalis (R&D) Ltd. (HitGen Inc.), SARomics Biostructures, WuXi AppTec, Schrödinger, Inc., and ZOBIO BV.

The competitive landscape is characterized by platform-building strategies, multi-disciplinary partnerships, and digital integration. Companies are investing in cloud-native Electronic Laboratory Notebooks (ELNs) compliant with FAIR data standards (Findable, Accessible, Interoperable, and Reusable) to streamline research collaboration and enhance data traceability.

In April 2025, Enamine and Pohang Accelerator Laboratory (PAL) announced a strategic Memorandum of Understanding (MoU) aimed at accelerating fragment-to-lead transitions through combined chemical development and advanced screening technologies. This collaboration exemplifies a growing trend toward risk-sharing and option-to-license agreements in the FBDD space.

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Future Outlook: FBDD as a Cornerstone for Mechanism-Driven Discovery
The future of fragment-based drug discovery is closely tied to the industry's shift toward mechanism-driven drug design and precision pharmacology. As therapeutic targets grow more complex, the flexibility of FBDD - coupled with next-generation screening tools and computational advancements - positions it as a sustainable and high-yield approach for pharmaceutical R&D.

Emerging frontiers in RNA-targeting fragments, molecular glues, and degrader discovery further highlight FBDD's potential to reshape modern drug pipelines. These advances are expected to reduce early-stage attrition rates, enhance target validation, and shorten time-to-market for innovative therapeutics.

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About Transparency Market Research

Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants use proprietary data sources and various tools & techniques to gather and analyses information.

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