Press release
Postoperative Pain Management Market Size Hits USD 41.17 Billion in 2024, Forecast to Grow at 5.4% CAGR Through 2033 | Exclusive Data Like Latest M & A, Regulatory Approvals, FDA Approvals, Latest Investments, Reimbursements - 2025
Postoperative Pain Management Market
DataM Intelligence has published a new research report on "Postoperative Pain Management Market Market Size 2025". The report explores comprehensive and insightful Information about various key factors like Regional Growth, Segmentation, CAGR, Business Revenue Status of Top Key Players and Drivers. The purpose of this report is to provide a telescopic view of the current market size by value and volume, opportunities, and development status.
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Latest M&A Activity:
In July 2025, Stryker and Boston Scientific made significant acquisitions to strengthen their interventional devices and digital testing portfolios for postoperative pain.
Eli Lilly announced a $1 billion acquisition of SiteOne Therapeutics in May 2025, targeting their NaV1.8 sodium channel inhibitor program, signaling aggressive moves towards next-gen non-opioid therapies.
Japanese pharmaceutical and device firms made cross-border acquisitions and joint ventures in early/mid-2025 to expand global non-opioid pain management solutions.
Ligand Pharmaceuticals (through Pelthos Therapeutics) merged with Channel Therapeutics in April 2025 to advance NaV1.7 pain management programs.
Key Players:
Pacira Pharmaceuticals, Inc., Heron Therapeutics, Inc., Mallinckrodt Pharmaceuticals, Johnson & Johnson, Vertex Pharmaceuticals Incorporated, Virpax Pharmaceuticals, Grünenthal, and Oakwood Labs, among others.
Reimbursement & Policy Trends
The NOPAIN Act, effective January 2025, mandates Medicare reimbursement for FDA-approved non-opioid pain drugs, removing a key access barrier and boosting market adoption, especially under new Centers for Medicare & Medicaid Services frameworks.
There is mounting payer and policy interest in AI-driven dosing, patient-controlled drug delivery, and multimodal regimens, with broader insurer acceptance expected as comparative trials continue to show opioid-sparing effectiveness.
Growth Forecast Projected:
The Global Postoperative Pain Management Market Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2032. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.
FDA Approvals:
In January 2025, the FDA approved Vertex Pharmaceuticals' JOURNAVX (suzetrigine), the first-in-class selective, non-opioid NaV1.8 inhibitor, for moderate-to-severe acute pain following surgery-marking a new regulatory milestone for non-opioid therapies.
In August 2025, the FDA approved KETARx (PharmaTher), a racemic ketamine-based medication, for post-surgical pain, expanding non-opioid options.
Allay Therapeutics secured approval to advance ATX101, an ultra-sustained pain platform, into Phase 2b clinical trials, fueling further innovation in long-acting local anesthetic solutions.
Research Process:
Both primary and secondary data sources have been used in the global Postoperative Pain Management Market Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.
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Key Segments:
By Drug Type:
Opioids | Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) | Local Anesthetics | Cyclooxygenase-2 (COX-2) Inhibitors | Others
By Route of Administration:
Injectable | Oral | Topical | Others
By Distribution Channel:
Hospital Pharmacies | Retail Pharmacies | Online Pharmacies.
Regional Analysis for Market:
⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)
Latest Investments:
August 2025: Johnson & Johnson (Janssen Pharmaceuticals) invested $40 million in R&D and manufacturing for non-opioid solutions, such as targeted analgesics and patient-controlled delivery systems, with product launches expected by Q1 2026.
June 2025: Allay Therapeutics closed a $57.5 million funding round to advance its ultra-sustained pain product trials.
Investments from major medical device firms and capital firms signal strong R&D growth, particularly in next-generation, non-opioid therapies.
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