RNA Therapeutics Market to Reach USD 23.5 Billion by 2030, Driven by Expanding mRNA and Gene-Based Drug Development

Introduction:

The RNA therapeutics market size is valued at USD 15.1 billion in 2025 and is forecasted to reach USD 23.5 billion in 2030, translating into a 9.2% CAGR during the assessment period. This growth reflects the rising acceptance of RNA-based interventions across multiple disease areas such as cancer, infectious diseases, and genetic disorders. Continued research collaborations, expanding manufacturing capacity, and regulatory approvals for mRNA vaccines and RNA interference drugs are shaping the future of personalized medicine.

The market's expansion is largely attributed to the post-pandemic momentum in RNA research, where platforms initially designed for vaccines are now being repurposed for chronic and rare diseases. Biotechnology and pharmaceutical companies are heavily investing in mRNA and antisense oligonucleotide (ASO) pipelines to address unmet medical needs, establishing RNA as a central pillar in next-generation therapeutics.

Report Overview: https://www.mordorintelligence.com/industry-reports/rna-therapeutics-market?utm_source=openpr

Key Trends Shaping the RNA Therapeutics Market

1. Advancements in mRNA-Based Vaccines and Therapeutics

One of the most influential RNA therapeutics market trends is the continued use of mRNA platforms beyond infectious disease prevention. mRNA-based therapeutics are being tested for applications in oncology, cardiovascular diseases, and autoimmune disorders. These products enable precise control over protein expression without altering the patient's genome, making them safer and more adaptable for diverse medical uses.

The development of self-amplifying RNA (saRNA) and circular RNA (circRNA) technologies is also gaining momentum. These formats enhance durability and stability of RNA molecules, reducing dosage requirements and manufacturing costs both key factors that support RNA therapeutics market growth globally.

2. Expansion of RNA Interference and Antisense Therapies

RNA interference (RNAi) and antisense oligonucleotide (ASO) drugs continue to demonstrate strong clinical success, particularly for liver-targeted disorders and neurological conditions. Several new RNAi and ASO drugs are in late-stage clinical trials, reflecting growing confidence in RNA-based mechanisms of action. Pharmaceutical companies are actively optimizing delivery systems to improve biodistribution and minimize immune reactions.

The rise in partnerships between RNA technology developers and contract manufacturing organizations (CMOs) further strengthens the RNA therapeutics market analysis. Strategic alliances help accelerate time-to-market, while investments in lipid nanoparticle (LNP) delivery systems enable large-scale production and storage stability.

3. Focus on Oncology and Rare Disease Applications

The oncology segment continues to account for a major share of the RNA therapeutics market, supported by the success of personalized cancer vaccines and gene-silencing treatments. RNA-based immunotherapies aim to trigger specific immune responses against tumor antigens, offering new possibilities for patients with limited treatment options.

Simultaneously, rare genetic diseases are emerging as a key growth area. RNA therapies provide an efficient approach for targeting genetic mutations without modifying DNA, which is particularly beneficial for conditions with no existing cures. The shift from broad immunization toward niche precision therapies reflects the market's diversification and long-term clinical potential.

Market Segmentation: Expanding Scope Across Drug Types and Applications

The RNA therapeutics market analysis indicates a broad segmentation framework covering product type, application, and geography.

By Therapeutic Modality

Antisense Oligonucleotides Small Interfering RNA (siRNA) MicroRNA (miRNA) Therapeutics Messenger RNA (mRNA) Therapeutics RNA Aptamers

By Application

Oncology

Genetic Disorders

Infectious Diseases

Cardiovascular & Metabolic Diseases

Neurological Disorders

By End User

Pharmaceutical & Biotechnology Companies

Academic & Research Institutions

Contract Research Organizations

Hospitals & Specialty Clinics

Others

By Geography

North America

South America

Europe

Asia pacific

Middle east&Africa

Key Players: Strengthening Global RNA Therapeutic Pipelines

Moderna

BioNTech

Alnylam Pharmaceuticals

Ionis Pharmaceuticals

Sarepta Therapeutics

Conclusion: RNA Therapeutics Positioned as the Future of Precision Medicine

The RNA therapeutics industry stands at the frontier of modern drug development, combining flexibility, scalability, and precision. The continued success of mRNA and RNAi technologies in clinical and commercial settings underscores their potential to redefine treatment paradigms. As manufacturing platforms mature and global regulatory frameworks adapt, RNA-based modalities are expected to enter mainstream healthcare across multiple therapeutic categories.

In summary, the RNA therapeutics market demonstrates robust prospects fueled by advances in vaccine technology, expansion into oncology and genetic disorders, and growing institutional support for RNA research.

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Related Reports

Nucleic Acid-Based Therapeutics Market: The Nucleic Acid-Based Therapeutics Market report segments the industry into By Product Type (RNA Interference [RNAi] And Short Interfering RNAs [siRNAs], Antisense Oligonucleotides (ASOs), and more), By Application (Autoimmune Disorders, Infectious Diseases, Genetic Disorders, and more), By End User (Hospitals And Clinics, Academic And Research Institutes), and By Geography (North America, Europe, and more).

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Lung Cancer Therapeutics Market: The Lung Cancer Therapeutics Market Report is Segmented by Disease Type (Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Others), Treatment Modality (Chemotherapy, and More), Drug Class (Small-Molecule Drugs, Biologics and Biosimilars), Distribution Channel (Hospital Pharmacies, and More), Line of Therapy (First-Line, and More), and Geography (North America, and More).

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Mordor Intelligence is a trusted partner for businesses seeking comprehensive and actionable market intelligence. Our global reach, expert team, and tailored solutions empower organizations and individuals to make informed decisions, navigate complex markets, and achieve their strategic goals.

With a team of over 550 domain experts and on-ground specialists spanning 150+ countries, Mordor Intelligence possesses a unique understanding of the global business landscape. This expertise translates into comprehensive syndicated and custom research reports covering a wide spectrum of industries, including aerospace & defense, agriculture, animal nutrition and wellness, automation, automotive, chemicals & materials, consumer goods & services, electronics, energy & power, financial services, food & beverages, healthcare, hospitality & tourism, information & communications technology, investment opportunities, and logistics.

For any inquiries or to access the full report, please contact:

media@mordorintelligence.com
https://www.mordorintelligence.com/

This release was published on openPR.