Minimal Residual Disease Pipeline 2025: Pioneering Clinical Developments by 8+ Global Innovators - DelveInsight | Highlighting Genentech, AmMax Bio, Elicio Therapeutics, Precigen Inc

DelveInsight's, "Minimal residual disease - Pipeline Insight, 2025" report provides comprehensive insights about 8+ companies and 8+ pipeline drugs in Minimal residual disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
With minimal residual disease (MRD) increasingly prevalent worldwide and linked to comorbidities such as diabetes, cardiovascular disorders, and certain cancers, there is a rising need for safer and more effective treatment options. DelveInsight reports that over 8 pharmaceutical and biotech companies are actively advancing more than 8 therapeutic candidates targeting MRD. These therapies are at various stages of clinical and preclinical development, reflecting significant innovation and dedication to tackling this critical public health challenge.

The "Minimal Residual Disease Pipeline Insight 2025" report by DelveInsight offers a comprehensive and strategic overview of the current R&D landscape. It examines clinical trial progress, emerging therapies, mechanisms of action, competitive dynamics, and major company initiatives. This report is an essential resource for researchers, healthcare investors, and decision-makers seeking insights into the evolving MRD therapeutics market and the breakthroughs shaping its future.

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Key Takeaways from the Minimal residual disease Pipeline Report

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DelveInsight's Minimal Residual Disease (MRD) pipeline report highlights a dynamic landscape, with over 8 companies actively developing more than 8 therapeutic candidates for MRD treatment.

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In early 2025, the FDA has been encouraging clinical trial designs to include MRD endpoints to speed up drug approvals, setting a precedent across oncology even ahead of formal guidance. Notably, in April 2024, the FDA's Oncologic Drugs Advisory Committee unanimously (12-0) endorsed using MRD negativity as a surrogate endpoint for accelerated approval in multiple myeloma trials, citing strong evidence that it predicts progression-free and overall survival. However, confirmatory trials are still required to validate long-term outcomes.

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Leading companies such as Genentech, AmMax Bio, Elicio Therapeutics, Precigen Inc., and others are actively evaluating new MRD therapies to advance treatment options. Promising candidates in the pipeline include AMB-066, ELI-002, and several others, representing a significant push to improve patient outcomes in MRD.

Minimal residual disease Overview:

Minimal Residual Disease (MRD) refers to a small number of cancer cells that remain in the body after treatment, even when standard clinical tests show no active disease. These cells are typically undetectable through imaging and do not cause noticeable symptoms, but they can reactivate, multiply, and potentially lead to cancer recurrence. MRD often persists due to incomplete responses to therapy or the development of treatment resistance in certain cancer cells. Monitoring MRD is crucial, as it provides insight into a patient's response to treatment and helps guide subsequent therapeutic decisions to prevent relapse.

Because MRD involves very few cancer cells, it usually does not produce symptoms. Unlike active cancer, it generally does not cause issues such as pain, fatigue, or significant weight changes. If residual cells begin to grow, symptoms will depend on the type and location of the cancer and may include abnormal blood counts, weakness, or organ dysfunction.

The biology of MRD involves multiple mechanisms that enable cancer cells to survive treatment. These include inherent therapy resistance, alterations in cell signaling pathways, and the ability to evade immune detection. MRD cells often inhabit protective niches, such as the bone marrow or central nervous system, where treatments are less effective. Genetic and epigenetic changes can further support their survival, dormancy, or slow proliferation. Over time, these cells may acquire additional mutations that drive disease recurrence, making MRD a key indicator of treatment resistance and a strong predictor of relapse.

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Minimal residual disease Pipeline Analysis

The Minimal residual disease pipeline insights report 2025, provides insights into:

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Provides comprehensive insights into key companies developing therapies in the Minimal residual disease Market.

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Categorizes Minimal residual disease therapeutic companies by development stage: early, mid, and late-stage.

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Highlights major companies involved in targeted therapy development, including both active and inactive (paused/discontinued) projects.

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Reviews emerging Minimal residual disease drugs under development based on:

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Stage of development

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Minimal residual disease Route of administration

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Target receptor

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Monotherapy vs. combination therapy

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Minimal residual disease Mechanism of action

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Molecular type

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Offers detailed analysis of:

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Company-to-company and company-academia collaborations

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Minimal residual disease Licensing agreements

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Funding and investment activities supporting future Minimal residual disease market advancement.

Unlock key insights into emerging Minimal residual disease therapies and market strategies here: https://www.delveinsight.com/report-store/minimal-residual-disease-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr

Minimal residual disease Emerging Drugs

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AMB-066: AmMax Bio

AMB-066 is a high-affinity monoclonal antibody that targets the colony stimulating factor 1 receptor (CSF1R) and is under investigation for treating minimal residual disease (MRD) in colorectal cancer (CRC). The antibody has previously been tested in approximately 200 participants, including patients and healthy volunteers, across five clinical trials for other indications. These studies, which explored intravenous, intra-articular, and subcutaneous administration, showed that AMB-066 is generally safe and well tolerated. It is now advancing through Phase II clinical trials specifically for MRD treatment.

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ELI-002: Elicio Therapeutics

Elicio's leading investigational therapy, ELI-002, is a novel AMP-based cancer vaccine aimed at tumors driven by KRAS gene mutations, which are common in several cancer types. The vaccine combines two key elements developed using Elicio's Amphiphile (AMP) technology: AMP-modified mutant KRAS peptide antigens and ELI-004, an AMP-modified CpG oligodeoxynucleotide adjuvant. Designed for convenient subcutaneous administration, ELI-002 is available off the shelf. It is currently being tested in a Phase I clinical trial for treating minimal residual disease (MRD).

Minimal residual disease Pipeline Therapeutic Assessment

Minimal residual disease Assessment by Product Type

- Mono

- Combination

- Mono/Combination

Minimal residual disease By Stage

- Late-stage products (Phase III)

- Mid-stage products (Phase II)

- Early-stage product (Phase I) along with the details of

- Pre-clinical and Discovery stage candidates

- Discontinued & Inactive candidates

Minimal residual disease Assessment by Route of Administration

- Oral

- Parenteral

- Intravenous

- Subcutaneous

- Topical

Minimal residual disease Assessment by Molecule Type

- Recombinant fusion proteins

- Small molecule

- Monoclonal antibody

- Peptide

- Polymer

- Gene therapy

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Table of Contents

1. Report Introduction

2. Executive Summary

3. Minimal residual disease Current Treatment Patterns

4. Minimal residual disease - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Minimal residual disease Late-Stage Products (Phase-III)

7. Minimal residual disease Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Minimal residual disease Discontinued Products

13. Minimal residual disease Product Profiles

14. Minimal residual disease Key Companies

15. Minimal residual disease Key Products

16. Dormant and Discontinued Products

17. Minimal residual disease Unmet Needs

18. Minimal residual disease Future Perspectives

19. Minimal residual disease Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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