United States Chronic Rhinosinusitis Treatment Market 2025 | Growth Drivers, Key Players & Investment Opportunities

Market Size and Growth

Global Chronic Rhinosinusitis Market reached USD 2.6 billion in 2022 and is expected to reach USD 4.5 billion by 2030, growing with a CAGR of 7.3% during the forecast period 2024-2031.

Key Development:

United States

✅ In October 2025, Lyra Therapeutics announced plans to conduct an additional clinical trial for its lead candidate, LYR-210, aimed at treating chronic rhinosinusitis without nasal polyps. The new trial design incorporates insights from previous studies and feedback from the FDA.

✅ In October 2025, Aptar Pharma and Dianosic entered into an exclusive partnership to develop the Active Resorbable Intranasal Scaffold (ARIS) technology platform. This collaboration focuses on creating an "insert and forget" intranasal drug delivery system to enhance patient adherence in treating chronic rhinitis and sinusitis.

✅ In July 2025, Sanofi reported positive Phase III study results for its pipeline drug tolebrutinib, targeting multiple sclerosis. This development underscores Sanofi's commitment to advancing treatments for chronic inflammatory conditions.

Japan

✅ In October 2025, Lyra Therapeutics announced plans to conduct an additional clinical trial for its lead candidate, LYR-210, aimed at treating chronic rhinosinusitis without nasal polyps. The new trial design incorporates insights from previous studies and feedback from the FDA.

✅ In October 2025, Aptar Pharma and Dianosic entered into an exclusive partnership to develop the Active Resorbable Intranasal Scaffold (ARIS) technology platform. This collaboration focuses on creating an "insert and forget" intranasal drug delivery system to enhance patient adherence in treating chronic rhinitis and sinusitis.

✅ In July 2025, Sanofi reported positive Phase III study results for its pipeline drug tolebrutinib, targeting multiple sclerosis. This development underscores Sanofi's commitment to advancing treatments for chronic inflammatory conditions.

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Recent Mergers and acquisitions:

United States
✅ In March 2025, Paratek Pharmaceuticals acquired Optinose in a deal valued at up to $330 million. This acquisition adds XHANCE®, a nasal spray for chronic rhinosinusitis, to Paratek's portfolio, expanding its presence in the ear, nose, and throat space.

✅ In March 2025, Optinose shareholders approved the merger proposal with Paratek Pharmaceuticals. Following the completion of the merger, Optinose's common stock was delisted from the Nasdaq Global Select Market, marking the finalization of the acquisition.

Key Players:

=> Lyra Therapeutics, Novartis, Medtronic plc, GlaxoSmithKline plc, AstraZeneca, Sanofi, Dr. Reddy's Laboratories Ltd, Stryker Corporation, Bayer AG, and Smith & Nephew.

Growth Forecast Projected:

The Global Chronic Rhinosinusitis Market is anticipated to rise at a considerable rate during the forecast period, between 2024 and 2031. In 2023, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

Research Process:

Both primary and secondary data sources have been used in the global Chronic Rhinosinusitis Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.

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Key Segments:

➥ By Disease Phenotype: Non-Eosinophilic Chronic Rhinosinusitis, Eosinophilic Chronic Rhinosinusitis, Infectious Chronic Rhinosinusitis, Allergic Fungal Rhinosinusitis, Others

➥ By Treatment Type: Medical Devices, Drugs, Nasal Drops, Steroid Nasal Sprays, Surgery, Others

➥ By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies

➥ By End-User: Hospitals, Specialty Clinics, Ambulatory Surgical Centers, Others

Regional Analysis for Chronic Rhinosinusitis Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

Benefits of the Report:

Chapter 1: Sets the stage by outlining the report's coverage, summarizing key market segments by region, product type, and application. Presents a snapshot of market sizes, growth potential across segments, and anticipated industry evolution both short and long term.

Chapter 2: Highlights pivotal market insights and uncovers the most significant emerging trends driving change within the industry.

Chapter 3: Offers an in-depth look at the competitive landscape among Chronic Rhinosinusitis producers, including revenue shares, strategic moves, and recent mergers and acquisitions.

Chapter 4: Presents comprehensive profiles of the market's key players, delving into details such as revenue, profit margins, product portfolios, and company milestones.

Chapters 5 & 6: Analyze Chronic Rhinosinusitis revenue at both regional and country levels, providing quantitative breakdowns of market sizes, growth opportunities, and development prospects worldwide.

Chapter 7: Focuses on different market segments by type, examining their individual sizes and potential, guiding readers toward high-impact, untapped market areas.

Chapter 8: Explores segmentation by application, evaluating industry growth potential in various downstream markets and pinpointing promising sectors for expansion.

Chapter 9: Provides a thorough review of the industry's supply chain mapping out both upstream and downstream activities.

Chapter 10: Concludes with a summary of the report's key findings and highlights the most critical takeaways for industry stakeholders.

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FAQ

What is the current size of the Chronic Rhinosinusitis Market?

A: In 2022, the Chronic Rhinosinusitis Market was valued at USD 2.6 billion , reflecting its strong industry presence.

Q2: How large is the Chronic Rhinosinusitis Market expected to be by 2030?

A: By 2030, industry forecasts suggest the Chronic Rhinosinusitis Market will grow to around USD 4.5 billion, demonstrating significant expansion.

Q3: What is the growth rate of the Chronic Rhinosinusitis Market?

A: The market is projected to expand at a compound annual growth rate (CAGR) of 7.3% during the forecast period from 2024 to 2031.

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