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United States Postoperative Pain Management Market 2025 | Growth Drivers, Key Players & Investment Opportunities
Postoperative Pain Management Market
The global postoperative pain management market size reached US$ 41.17 Billion in 2024 from US$ 39.26 Billion in 2023 and is expected to reach US$ 65.36 Billion by 2033, growing at a CAGR of 5.4% during the forecast period 2025-2033.
Key Development:
United States: Recent Industry Developments
✅ August 2025: Johnson & Johnson (Janssen Pharmaceuticals) invested $40 million to expand R&D and manufacturing of non-opioid postoperative pain management solutions in New Jersey. The initiative focuses on targeted analgesics and patient-controlled delivery systems, with a commercial rollout expected by Q1 2026.
✅ June 2025: Allay Therapeutics announced a $57.5 million Series D financing to advance ATX101 and its ultra-sustained pain platform for post-surgical pain management. The funds will support a Phase 2b trial in total knee replacement patients, with data anticipated in Q4 2025.
✅ May 2025: Viatris announced positive results from its Phase III program for MR-107A-02, a novel fast-acting formulation of meloxicam for treating moderate-to-severe acute pain. The company plans to submit a New Drug Application (NDA) to the U.S. FDA by the end of 2025.
Japan: Recent Industry Developments
✅ September 2025: Japanese scientists developed ADRIANA, a non-opioid painkiller offering powerful relief without the dangers of addiction. Successful trials have been completed, and large U.S. studies are now underway, raising hopes for a safer future in pain treatment.
✅ June 2025: Allay Therapeutics announced a $57.5 million Series D financing to advance ATX101 and its ultra-sustained pain platform for post-surgical pain management. The funds will support a Phase 2b trial in total knee replacement patients, with data anticipated in Q4 2025.
✅ April 2022: The Japanese government introduced a new Acute Pain Service (APS) fee addition into the healthcare reimbursement system to promote structured APS implementation. This initiative aims to enhance postoperative pain management across the country.
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Recent Mergers and Acquisitions:
United States: Recent Mergers & Acquisitions
✅ January 2025: Lantheus Holdings, a leader in radiopharmaceuticals, expanded its portfolio through strategic acquisitions, enhancing its position in the biopharmaceutical industry and reinforcing its commitment to innovative pain management solutions.
✅ July 2025: MedTech giants Stryker and Boston Scientific made significant acquisitions in the pain management sector, aiming to bolster their capabilities in interventional devices and digital testing, thereby advancing treatment options for postoperative pain.
✅ April 2025: The healthcare M&A market experienced a resurgence, with increased deal activity reflecting renewed confidence in the sector. This trend is expected to continue, potentially leading to further consolidations in postoperative pain management.
Japan: Recent Mergers & Acquisitions
✅ January 2025: In a strategic move to enhance its presence in pain management, a leading Japanese pharmaceutical company acquired a U.S.-based biotech firm specializing in non-opioid analgesics, aiming to diversify its portfolio and address postoperative pain more effectively.
✅ June 2025: A Japanese medical device manufacturer expanded its reach by acquiring a European company known for its innovative pain management technologies, strengthening its position in the global postoperative pain management market.
✅ March 2025: A Japanese healthcare conglomerate entered into a joint venture with a U.S. pain management startup, focusing on developing advanced digital therapeutics for postoperative pain, reflecting a growing trend of international collaborations in the field.
Key Players:
=> Pacira Pharmaceuticals, Inc., Heron Therapeutics, Inc., Mallinckrodt Pharmaceuticals, Johnson & Johnson, Vertex Pharmaceuticals Incorporated, Virpax Pharmaceuticals, Grünenthal, and Oakwood Labs, among others.
Growth Forecast Projected:
The Global Postoperative pain management Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2033. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.
Research Process:
Both primary and secondary data sources have been used in the global Postoperative pain management Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.
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Key Segments:
➥ By Drug Type: Opioids, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Local Anesthetics, Cyclooxygenase-2 (COX-2) Inhibitors, Others
➥ By Route of Administration: Injectable, Oral, Topical, Others
➥ By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies
Regional Analysis for Postoperative pain management Market:
⇥ North America (U.S., Canada, Mexico)
⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)
⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)
⇥ South America (Colombia, Brazil, Argentina, Rest of South America)
⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)
Benefits of the Report:
Chapter 1: Sets the stage by outlining the report's coverage, summarizing key market segments by region, product type, and application. Presents a snapshot of market sizes, growth potential across segments, and anticipated industry evolution both short and long term.
Chapter 2: Highlights pivotal market insights and uncovers the most significant emerging trends driving change within the industry.
Chapter 3: Offers an in-depth look at the competitive landscape among Postoperative pain management producers, including revenue shares, strategic moves, and recent mergers and acquisitions.
Chapter 4: Presents comprehensive profiles of the market's key players, delving into details such as revenue, profit margins, product portfolios, and company milestones.
Chapters 5 & 6: Analyze Postoperative pain management revenue at both regional and country levels, providing quantitative breakdowns of market sizes, growth opportunities, and development prospects worldwide.
Chapter 7: Focuses on different market segments by type, examining their individual sizes and potential, guiding readers toward high-impact, untapped market areas.
Chapter 8: Explores segmentation by application, evaluating industry growth potential in various downstream markets and pinpointing promising sectors for expansion.
Chapter 9: Provides a thorough review of the industry's supply chain mapping out both upstream and downstream activities.
Chapter 10: Concludes with a summary of the report's key findings and highlights the most critical takeaways for industry stakeholders.
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FAQ
What is the current size of the Postoperative pain management Market?
A: In 2024, the Postoperative pain management Market was valued at US$ 41.17 Billion, reflecting its strong industry presence.
Q2: How large is the Postoperative pain management Market expected to be by 2033?
A: By 2033, industry forecasts suggest the Postoperative pain management Market will grow to around US$ 65.36 Billion , demonstrating significant expansion.
Q3: What is the growth rate of the Postoperative pain management Market?
A: The market is projected to expand at a compound annual growth rate (CAGR) of 5.4% during the forecast period from 2025 to 2033.
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