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RNAi Therapeutics and Technology Market to Reach USD 17.6 Billion by 2034

10-03-2025 01:27 PM CET | Health & Medicine

Press release from: Exactitude Consultancy

RNAi Therapeutics and Technology Market

RNAi Therapeutics and Technology Market

Introduction
The RNA interference (RNAi) therapeutics and technology market has rapidly evolved from a groundbreaking scientific discovery into a transformative force in modern medicine. With its ability to silence disease-causing genes at the molecular level, RNAi is being hailed as one of the most promising frontiers in biotechnology. Over the past two decades, RNAi-based therapeutics have transitioned from theoretical potential to commercial reality, unlocking pathways to treat diseases once considered untreatable.

As healthcare systems worldwide shift toward precision medicine and targeted therapies, RNAi technologies have gained traction for their ability to deliver highly specific interventions. The surge in chronic diseases, cancer, genetic disorders, and rare diseases, coupled with strong investments from pharmaceutical giants and biotech start-ups, positions the RNAi market for exponential growth.

According to Exactitude Consultancy, the RNAi therapeutics and technology market was valued at USD 6.8 billion in 2024 and is projected to reach USD 17.6 billion by 2034, growing at a CAGR of 10.3%. This robust expansion highlights the market's significant role in shaping the future of biotechnology, diagnostics, and pharmaceutical innovation.

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Market Overview
• Market Size (2024): USD 6.8 billion
• Forecast (2034): USD 17.6 billion
• CAGR (2025-2034): 10.3%
• Largest Market Region: North America

The market's growth is fueled by the rising prevalence of genetic and chronic diseases, strong adoption of advanced drug discovery platforms, and increasing collaboration between pharmaceutical companies and biotech innovators. Notably, the first FDA-approved RNAi drug, Onpattro (patisiran) by Alnylam Pharmaceuticals, opened the door for further RNAi-based therapies, setting a benchmark for commercial success.

Key Growth Drivers
• Rising demand for targeted and personalized medicine.
• Expanding applications of RNAi in oncology, cardiovascular, metabolic, and infectious diseases.
• Increasing research collaborations, licensing deals, and investments.
• Technological advances in delivery platforms and nanoparticle formulations.

Challenges
• High R&D costs and long development timelines.
• Delivery-related complexities, particularly targeting tissues beyond the liver.
• Regulatory hurdles and safety concerns related to off-target effects.

Leading Players
• Alnylam Pharmaceuticals
• Ionis Pharmaceuticals
• Moderna
• Dicerna Pharmaceuticals (Novo Nordisk subsidiary)
• Arrowhead Pharmaceuticals
• Sirnaomics
• Silence Therapeutics
• Thermo Fisher Scientific
• Qiagen N.V.

These companies are actively advancing product pipelines, forming strategic alliances, and innovating RNAi delivery technologies to maintain their competitive edge.

Segmentation Analysis
The RNAi therapeutics and technology market is segmented by product, platform, technology, end use, and application.
By Product
• siRNA (small interfering RNA)
• miRNA (micro RNA)
• shRNA (short hairpin RNA)
• Antisense oligonucleotides (ASOs)

By Platform
• Delivery technologies (lipid nanoparticles, conjugates)
• RNAi screening platforms
• RNAi drug discovery tools
By Technology
• RNA interference (RNAi)
• Antisense technology
• CRISPR/RNAi hybrid systems

By End Use
• Biotechnology & pharmaceutical companies
• Academic & research institutes
• Contract research organizations (CROs)

By Application
• Oncology
• Genetic disorders
• Infectious diseases
• Cardiovascular diseases
• Metabolic disorders
• Others (neurological, ophthalmic)

Summary:
The oncology segment dominates applications due to the rising incidence of cancer and RNAi's unique potential to silence oncogenes. Biotech and pharma companies remain the largest end users, driving RNAi adoption in therapeutic development and precision drug discovery. Delivery technologies represent the most critical platform area, as effective delivery remains a key barrier and innovation hotspot in RNAi therapeutics.

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Regional Analysis
North America
• Largest market, led by the United States.
• Strong R&D investments, advanced healthcare infrastructure, and FDA approvals support growth.
• Key players like Alnylam, Arrowhead, and Moderna drive innovation.
Europe
• Growing adoption in Germany, UK, and France.
• Strong research base in RNA technologies, supported by EU funding.
• Increasing focus on rare diseases and orphan drug development.
Asia-Pacific
• Fastest-growing region, led by China, Japan, South Korea, and India.
• Expanding biotech ecosystems and clinical trials.
• Government incentives and academic research collaborations accelerating adoption.
Middle East & Africa
• Emerging market with opportunities in rare genetic disorder treatments.
• Healthcare modernization and early-stage research are fueling gradual adoption.
Latin America
• Brazil and Mexico are leading contributors.
• Rising pharmaceutical partnerships and growing demand for advanced therapeutics.
Summary:
North America holds the largest share due to early commercialization and strong innovation pipelines, while Asia-Pacific is expected to post the fastest CAGR through 2034. Europe remains a critical research hub, whereas Latin America and MEA are emerging opportunities for expansion.

Market Dynamics
Growth Drivers
1. Increasing prevalence of cancer, cardiovascular, and rare genetic diseases.
2. Advances in nanoparticle delivery systems and conjugate chemistries.
3. Strong pipeline of RNAi drugs under clinical trials.
4. Strategic partnerships between big pharma and biotech startups.

Challenges
1. Technical hurdles in delivering RNAi beyond the liver.
2. High regulatory scrutiny and long approval processes.
3. Market entry barriers for smaller players due to capital-intensive R&D.

Latest Trends
• Expansion beyond liver-targeted drugs to neurological and muscular disorders.
• Growing use of artificial intelligence and machine learning in RNAi drug discovery.
• Collaborations for combination therapies, pairing RNAi with small molecules or monoclonal antibodies.
• Expansion of RNAi technologies in agriculture and animal health research.

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Competitor Analysis
Key Players
• Alnylam Pharmaceuticals - Pioneer with FDA-approved RNAi therapies (Onpattro, Givlaari, Oxlumo, Amvuttra).
• Ionis Pharmaceuticals - Leader in antisense oligonucleotide technology.
• Moderna - Expanding RNA-based innovation beyond mRNA vaccines into RNAi.
• Dicerna Pharmaceuticals (Novo Nordisk) - Focus on rare and metabolic disorders.
• Arrowhead Pharmaceuticals - Strong pipeline in liver and cardiovascular RNAi therapies.
• Sirnaomics - Active in oncology and fibrosis research.
• Silence Therapeutics - Advancing GalNAc-based delivery platforms.
• Thermo Fisher Scientific & Qiagen N.V. - Providing enabling technologies, reagents, and RNAi screening tools.

Summary:
The competitive landscape is marked by intense innovation, with Alnylam leading commercial adoption, while other biotech players push forward diverse pipelines. Strategic acquisitions, licensing deals, and collaborations with big pharma are shaping a dynamic ecosystem. Delivery innovation remains the key battleground for differentiation.

Conclusion
The RNAi therapeutics and technology market is poised for sustained double-digit growth, expanding from USD 6.8 billion in 2024 to USD 17.6 billion by 2034 at a CAGR of 10.3%. With its precision, versatility, and ability to silence disease-driving genes, RNAi is redefining drug discovery and patient care across oncology, rare diseases, infectious conditions, and beyond.

While challenges around delivery, safety, and regulatory approval persist, ongoing innovation in conjugate chemistries, AI-driven discovery, and partnerships between biotech and pharma leaders will continue to propel the field forward.

Opportunities abound for companies that can address delivery barriers, expand applications beyond the liver, and bring cost-effective therapies to market. With robust pipelines, global investments, and rising demand for precision medicine, RNAi technologies are set to become a cornerstone of next-generation therapeutics.

This report is also available in the following languages : Japanese (RNAi治療薬とテクノロジー), Korean (RNAi 치료 및 기술), Chinese (RNAi治疗与技术), French (Thérapeutique et technologie de l'ARNi), German (RNAi-Therapeutika und -Technologie), and Italian (Terapie e tecnologie RNAi), etc.

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Our More Reports:

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https://exactitudeconsultancy.com/reports/73118/cell-therapy-manufacturing-market

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https://exactitudeconsultancy.com/reports/73116/adc-technology-market

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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
https://bulletin.exactitudeconsultancy.com/

https://www.thehealthanalytics.com/

https://www.analytica.global/

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https://exactitudeconsultancy.com/

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EMAIL ADDRESS: sales@exactitudeconsultancy.com

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