Next-Gen Drug Testing: United States Organ-On-Chip Market Enters High-Growth Phase | Top Companies - Emulate Inc., Mimetas B.V., Insphero, Organovo Holdings

Market Size and Growth

According to the DataM Intelligence: The US organ on chip market size was valued as US$ 59.40 million in 2024 and is expected to reach US$ 753.46 million by 2033, growing at a CAGR of 32.6% during the forecast period 2025-2033.

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Key Development:

✅ In June 2025, Emulate has introduced the AVA Emulation System, a self-contained instrument capable of culture, incubating, and imaging up to 96 independent organ-chip samples in a single run, delivering in vivo-level insights faster than animal models and reducing consumable costs and in-lab labor.

✅ In April 2025, The U.S. Food and Drug Administration (FDA) has introduced a transformative approach to drug development by moving away from traditional animal testing and adopting human-relevant methods such as organ-on-chip technology. This strategic shift is designed to enhance drug safety, accelerate the evaluation process, reduce reliance on animal experimentation, and lower research and development costs.

Key Players:

=> The top companies in US organ on chip market includes Emulate, Inc., Valo Health, Nortis, Inc., AxoSim, BICO-THE BIO CONVERGENCE COMPANY, CN Bio Innovations Ltd, The Charles Stark Dr@per Laboratory, Inc., SynVivo, Inc and among others.

Growth Forecast Projected:

The Global Organ-On-Chip Market is anticipated to rise at a considerable rate during the forecast period, between 2025 and 2033. In 2024, the market is growing at a steady rate, and with the rising adoption of strategies by key players, the market is expected to rise over the projected horizon.

Research Process:

Both primary and secondary data sources have been used in the global Organ-On-Chip Market research report. During the research process, a wide range of industry-affecting factors are examined, including governmental regulations, market conditions, competitive levels, historical data, market situation, technological advancements, upcoming developments, in related businesses, as well as market volatility, prospects, potential barriers, and challenges.

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Key Segments:

➥ By Model: Liver-On-Chip Model, Lung-On-Chip Model, Heart-On-Chip Model, Kidney-On-Chip Model, Tumor Models, Custom & Multi-Organ-On-Chip Models, Others
➥ By Application: Drug Discovery, Physiological Model Development, Toxicology Research
➥ By End User: Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, Others

Regional Analysis for Organ-On-Chip Market:

⇥ North America (U.S., Canada, Mexico)

⇥ Europe (U.K., Italy, Germany, Russia, France, Spain, The Netherlands and Rest of Europe)

⇥ Asia-Pacific (India, Japan, China, South Korea, Australia, Indonesia Rest of Asia Pacific)

⇥ South America (Colombia, Brazil, Argentina, Rest of South America)

⇥ Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of Middle East & Africa)

Benefits of the Report:

Chapter 1: Sets the stage by outlining the report's coverage, summarizing key market segments by region, product type, and application. Presents a snapshot of market sizes, growth potential across segments, and anticipated industry evolution both short and long term.

Chapter 2: Highlights pivotal market insights and uncovers the most significant emerging trends driving change within the industry.

Chapter 3: Offers an in-depth look at the competitive landscape among Organ-On-Chip producers, including revenue shares, strategic moves, and recent mergers and acquisitions.

Chapter 4: Presents comprehensive profiles of the market's key players, delving into details such as revenue, profit margins, product portfolios, and company milestones.

Chapters 5 & 6: Analyze Organ-On-Chip revenue at both regional and country levels, providing quantitative breakdowns of market sizes, growth opportunities, and development prospects worldwide.

Chapter 7: Focuses on different market segments by type, examining their individual sizes and potential, guiding readers toward high-impact, untapped market areas.

Chapter 8: Explores segmentation by application, evaluating industry growth potential in various downstream markets and pinpointing promising sectors for expansion.

Chapter 9: Provides a thorough review of the industry's supply chain mapping out both upstream and downstream activities.

Chapter 10: Concludes with a summary of the report's key findings and highlights the most critical takeaways for industry stakeholders.

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FAQ

What is the current size of the Organ-On-Chip Market?

A: In 2024, the Organ-On-Chip Market was valued at US$ 59.40 million, reflecting its strong industry presence.

Q2: How large is the Organ-On-Chip Market expected to be by 2033?

A: By 2033, industry forecasts suggest the Organ-On-Chip Market will grow to around US$ 753.46 million , demonstrating significant expansion.

Q3: What is the growth rate of the Organ-On-Chip Market?

A: The market is projected to expand at a compound annual growth rate (CAGR) of 32.6% during the forecast period from 2025 to 2033.

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Author: Gundreddy Gopinadh is a healthcare research analyst with over a decade of experience in medical devices, pharmaceuticals, biotechnology, and in-vitro diagnostics (IVD). He specializes in delivering actionable insights through custom market research projects, helping organizations analyze trends, assess competitive landscapes, and uncover growth opportunities. His expertise has guided healthcare companies in product development, strategic planning, and market expansion, positioning him as a trusted contributor to data-driven innovation in the global healthcare industry.

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