Press release
Neovascular Age-Related Macular Degeneration Market to Grow at 6.2% CAGR, Reaching USD 22.8 Billion by 2034
Neovascular Age-Related Macular Degeneration Market
Neovascular age-related macular degeneration (nAMD), also known as "wet AMD," is a leading cause of irreversible vision loss among older adults worldwide. Unlike dry AMD, which progresses slowly, nAMD is characterized by abnormal blood vessel growth under the retina, leading to rapid vision deterioration if untreated. The social and economic burden of nAMD is significant, as it directly affects independence, quality of life, and healthcare systems.
Over the past decade, treatment paradigms for nAMD have transformed with the development of anti-VEGF (vascular endothelial growth factor) therapies, dramatically improving patient outcomes. With an aging global population, increasing life expectancy, and ongoing drug development, the nAMD market is positioned for sustained growth. By 2034, the market will be shaped by innovations in long-acting formulations, gene therapies, and digital monitoring technologies.
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Market Overview
• Market Size (2024): USD 12.6 billion
• Forecast (2034): USD 22.8 billion
• CAGR (2024-2034): ~6.2%
Key Highlights:
• Growing prevalence of AMD due to demographic aging and lifestyle changes.
• Anti-VEGF therapies such as ranibizumab, aflibercept, and brolucizumab dominate the treatment landscape.
• Long-acting injectables, port delivery systems, and gene therapies are key innovation areas.
• Rising healthcare expenditure and reimbursement support boosting patient access.
Leading Players: Regeneron Pharmaceuticals, Novartis, Roche/Genentech, Bayer AG, Biogen, Apellis Pharmaceuticals, and Kodiak Sciences are among the top companies shaping the global market.
Key Drivers: Global aging trends, high unmet clinical needs, and advancements in drug delivery.
Key Challenges: High treatment costs, need for frequent intravitreal injections, and limited awareness in developing economies.
Segmentation Analysis
By Product
• Anti-VEGF Therapies (ranibizumab, aflibercept, brolucizumab, bevacizumab)
• Biosimilars
• Gene Therapies (pipeline products)
• Long-Acting Delivery Systems (port delivery implants, sustained release)
• Others (complement inhibitors, novel biologics)
By Platform
• Prescription Drugs
• Specialty Biologics
• Biosimilars and Generics
By Technology
• Intravitreal Injections
• Port Delivery Systems
• Gene Therapy Platforms
• Sustained Release Implants
• Digital Monitoring & AI Tools
By End Use
• Hospitals
• Ophthalmology Clinics
• Specialty Eye Care Centers
• Ambulatory Surgical Centers
By Application
• Newly Diagnosed Patients
• Relapsed/Recurrent Cases
• Clinical Research & Trials
Summary: Anti-VEGF biologics dominate the market, but the future lies in gene therapy, sustained delivery, and digital care models. These innovations aim to reduce treatment burden, improve adherence, and expand access to underserved populations.
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Regional Analysis
North America
• Largest market due to high healthcare spending and advanced treatment access.
• Strong presence of leading pharmaceutical innovators (Roche, Regeneron, Novartis).
• Favorable reimbursement coverage and high adoption of novel therapies.
Europe
• Major markets include Germany, UK, France, and Italy.
• Strong regulatory and reimbursement frameworks support adoption of biologics.
• Growing demand for biosimilars and affordability-focused treatments.
Asia-Pacific
• Fastest-growing region due to rapid population aging in China, Japan, and South Korea.
• Expanding healthcare infrastructure and government-led awareness programs.
• Increasing participation in clinical trials and biosimilar development.
Middle East & Africa
• Rising recognition of AMD-related vision loss, particularly in urban areas.
• Limited access to advanced biologics, but improving availability of generics.
• GCC nations leading investments in ophthalmic care infrastructure.
Latin America
• Moderate growth, with Brazil and Mexico driving adoption.
• Expanding ophthalmology networks and medical tourism boosting regional uptake.
• Local manufacturers playing a role in affordable biosimilar production.
Summary: North America and Europe dominate in market share due to early adoption of biologics, but Asia-Pacific is the growth hotspot, driven by demographic shifts, expanding access, and rising clinical trial activity.
Market Dynamics
Key Growth Drivers
1. Aging Population: Rising prevalence of AMD among people aged 60+.
2. Therapeutic Innovation: Next-gen biologics, biosimilars, and gene therapies.
3. Drug Delivery Advances: Long-acting injectables and port delivery systems reducing treatment frequency.
4. Healthcare Investment: Growing global expenditure on ophthalmic care and reimbursement expansion.
Key Challenges
1. High Treatment Costs: Anti-VEGF biologics remain costly, limiting access in low-income regions.
2. Frequent Injections: Current therapies often require monthly dosing, creating treatment burden.
3. Access Inequalities: Underdiagnosis and lack of ophthalmologists in developing countries.
4. Regulatory Delays: Lengthy approval processes for novel biologics and gene therapies.
Latest Trends
• Gene Therapy Trials: Potential for one-time treatments showing promising outcomes.
• Digital Health Integration: AI-driven diagnostic tools and remote monitoring solutions.
• Biosimilars Expansion: Lower-cost alternatives entering markets in Asia and Europe.
• Combination Therapies: Exploring synergies between VEGF inhibitors and complement pathway drugs.
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Competitor Analysis
Major Players:
• Regeneron Pharmaceuticals
• Novartis AG
• Roche/Genentech
• Bayer AG
• Biogen Inc.
• Apellis Pharmaceuticals
• Kodiak Sciences Inc.
• Samsung Bioepis (biosimilars)
• Outlook Therapeutics
• Adverum Biotechnologies
Competitive Dynamics:
The nAMD market is highly competitive, dominated by global pharmaceutical giants with blockbuster anti-VEGF therapies. However, the entry of biosimilars is increasing price competition, especially in cost-sensitive markets. Companies are investing heavily in gene therapy pipelines and long-acting delivery platforms to reduce treatment burden and improve outcomes, with collaborations between biotech firms and research institutions accelerating innovation.
Conclusion
The neovascular age-related macular degeneration market is set to grow from USD 12.6 billion in 2024 to USD 22.8 billion by 2034, registering a CAGR of ~6.2%. Demographic aging, therapeutic innovation, and enhanced global access to biologics are the primary growth engines.
While affordability and access challenges persist in low- and middle-income countries, the industry is moving toward longer-lasting treatments, gene therapy breakthroughs, and digital health integration. Biosimilars will also play a pivotal role in expanding treatment accessibility globally.
This report is also available in the following languages : Japanese (新生血管加齢黄斑変性市場), Korean (신생혈관성 연령관련 황반변성 시장), Chinese (新生血管性年龄相关性黄斑变性市场), French (Marché de la dégénérescence maculaire néovasculaire liée à l'âge), German (Markt für neovaskuläre altersbedingte Makuladegeneration), and Italian (Mercato della degenerazione maculare neovascolare legata all'età), etc.
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Optic Neuritis Market
https://exactitudeconsultancy.com/reports/72238/optic-neuritis-market
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