The Increase in Prevalence of Genetic Disorders Fueling the Growth of the Market Due to Rising Demand for Targeted Treatments and Early Detection Driving Market Acceleration in the Propionic Acidemia Industry, 2025

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How Large Will the Propionic Acidemia Market Size By 2025?
In recent times, the market size for propionic acidemia has seen a consistent uptick. The market, which is projected to be worth $2 billion in 2024, is forecasted to rise to $2.07 billion in 2025, representing a compound annual growth rate (CAGR) of 3.5%. The augmentation in this historical period can be accredited to a surge in the disease's prevalence, an escalation in newborn screenings, heightened healthcare spending, an increase in the diagnosis amongst children, and expansion in initiatives aimed at rare diseases.

How Big Is the Propionic Acidemia Market Size Expected to Grow by 2029?
The market for propionic acidemia is anticipated to witness consistent expansion in the upcoming years, reaching $2.43 billion by 2029 with a 4.1% compound annual growth rate (CAGR). The sustained growth during the forecast period can be credited to the rise in awareness initiatives, an escalation in metabolic disorder instances, the surge in telemedicine utilization, the growth in the demand for tailored treatments, and amplified healthcare investments. Significant trends anticipated during the forecast period encompass advancements in diagnostic technology, the emergence of gene therapies, the modernization of metabolic therapies, AI incorporation in healthcare, and the creation of novel therapeutics.

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Which Key Market Drivers Powering Propionic Acidemia Market Expansion and Growth?
The growth of the propionic acidemia market is projected to skyrocket due to the rising incidence of genetic disorders. Genetic disorders are conditions triggered by changes or abnormalities in a person's DNA, which can either be inherited or spontaneously occur, impacting an individual's health and development. The rising frequency of genetic disorders can be attributed to consanguineous marriages that elevate the risk of passing on recessive genetic mutations, given that the same faulty genes can be inherited from both parents, thereby significantly enhancing the risk of genetic conditions. Propionic acidemia plays a key role in managing genetic disorders by providing targeted treatments to rectify metabolic imbalances, thereby ameliorating patient outcomes. For instance, a report published by the Cystic Fibrosis (CF) Foundation, a US-based non-profit institution, in July 2022 informed that the incidence of cystic fibrosis has incremented and nearly 40,000 children and adults in the United States were affected in 2022, with over 105,000 diagnoses made worldwide. Consequently, the surge in genetic disorders incidence is stimulating the growth of the acidemia market.

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Which Fast-Growing Trends Are Poised to Disrupt the Propionic Acidemia Market?
Leading businesses in the propionic acidemia market are honing their focus on the creation of novel mRNA-based treatments, which aim to tackle the root genetic causes of the condition. mRNA treatments are a class of therapy that utilizes messenger RNA to direct cells to create proteins which can either prevent or effectively treat diseases by addressing the fundamental genetic causes. For example, Moderna, an American pharmaceutical and biotechnology corporation, released provisional data from the Phase 1/2 trial of mRNA-3927 in May 2023. This experimental mRNA treatment for propionic acidemia employs mRNA to transport functional versions of the PCCA and PCCB genes, thereby restoring enzyme activity in the liver and potentially lessening metabolic decompensations. This groundbreaking treatment strategy aims to enhance patient results by confronting the genetic underpinning of the disease, providing fresh hope for those impacted by this uncommon metabolic disorder.

What Are the Emerging Segments in the Propionic Acidemia Market?
The propionic acidemiamarket covered in this report is segmented -

1) By Drug Class: L-Carnitine, Antibiotics
2) By Route of Administration: Oral, Intravenous, Intramuscular
3) By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies

Subsegments:

1) By L-Carnitine Drug Class: Oral L-Carnitine, Injectable L-Carnitine
2) By Antibiotics Drug Class: Oral Antibiotics, Injectable Antibiotics

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Who Are the Global Leaders in the Propionic Acidemia Market?
Major companies operating in the propionic acidemia market are Moderna Therapeutics, Synlogic Therapeutics, Invitae Corporation, Global Calcium, BridgeBio Pharma, AdvaCare Pharma, HemoShear Therapeutics, DNA Labs, Velnex Medicare, Phytologix Life Scieneces, Liaoning Koncepnutra Co. Ltd., Propionic Acidemia Foundation, Agex Pharma, Gladfem, CSL Behring, Octapharma AG, Sanquin, Kedrion SpA, Shire plc, Vitane Pharmaceuticals Inc.

Which are the Top Profitable Regional Markets for the Propionic Acidemia Industry?
North America was the largest region in the propionic acidemia market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the propionic acidemia market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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