Press release
Postoperative Pain Market is expected to reach USD 58.9 billion by 2034
Postoperative Pain
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Traditionally, pain has been managed with opioids, non-steroidal anti-inflammatory drugs (NSAIDs), and local anesthetics. However, the risks of opioid dependence, side effects, and the need for multimodal approaches have reshaped the treatment paradigm. Emerging options include long-acting regional anesthetics, non-opioid analgesics, nerve blocks, neuromodulation, and digital monitoring platforms. Between 2024 and 2034, the postoperative pain market is expected to expand steadily, supported by innovations in multimodal analgesia, opioid-sparing strategies, and patient-centered recovery programs.
Market Overview
• Market Size 2024: USD 38.5 billion (estimated)
• Forecasted Market Size 2034: USD 58.9 billion
• CAGR (2024-2034): 4.4%
Key Highlights
• Rising global surgical volumes across orthopedics, oncology, cardiovascular, and general surgery.
• Expanding adoption of non-opioid and multimodal pain management approaches.
• Growing awareness of opioid-related risks driving innovation.
• Increasing role of digital health and remote monitoring in recovery.
Segmentation Analysis
By Product
• Pharmacological therapies
o Opioids (morphine, oxycodone, hydromorphone, fentanyl)
o NSAIDs (ibuprofen, diclofenac)
o Local anesthetics (bupivacaine, lidocaine, ropivacaine)
o COX-2 inhibitors (celecoxib, parecoxib)
o Non-opioid analgesics (acetaminophen, gabapentinoids)
• Regional anesthetics & nerve blocks
o Long-acting local anesthetic formulations (liposomal bupivacaine)
o Continuous peripheral nerve blocks
• Device-based therapies
o Neuromodulation systems
o Patient-controlled analgesia (PCA) devices
• Pipeline innovations
o Extended-release non-opioid formulations
o Gene and regenerative pain management therapies
By Platform
• Hospital pharmacies
• Retail pharmacies
• Online pharmacies
• Ambulatory surgery centers (ASCs)
By Technology
• Oral pharmacological therapies
• Injectable and IV drug delivery
• Transdermal and topical patches
• Device-based pain management solutions
• Digital monitoring platforms
By End Use
• Hospitals and surgical centers
• Ambulatory surgical centers
• Homecare and outpatient recovery
By Application
• Orthopedic surgeries (joint replacement, spine, trauma)
• Cardiovascular surgeries
• Cancer-related surgeries
• General surgeries (abdominal, gynecological, urological)
• Others (ENT, plastic, emergency surgeries)
Summary:
Pharmacological treatments dominate, but non-opioid extended-release formulations, device-based solutions, and digital monitoring tools are gaining strong momentum.
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Regional Analysis
North America
• Largest market share in 2024, driven by high surgical volumes, advanced hospital infrastructure, and strong adoption of multimodal pain management.
• U.S. opioid crisis fueling rapid uptake of opioid-sparing and non-opioid therapies.
Europe
• Significant market share with strong adoption of regional anesthesia and multimodal regimens.
• Germany, France, and the UK lead in integrating digital recovery platforms.
Asia-Pacific
• Fastest-growing region (CAGR ~5.6%), driven by expanding surgical demand in China, India, and Japan.
• Increasing healthcare investment and growing focus on affordable non-opioid alternatives.
Middle East & Africa
• Rising healthcare infrastructure investment, particularly in GCC nations.
• Gradual adoption of advanced anesthetics and digital recovery solutions.
Latin America
• Brazil and Mexico leading adoption, with growing access to generics and regional anesthesia techniques.
• Expanding private healthcare facilities driving demand.
Summary:
While North America and Europe dominate today, Asia-Pacific is expected to see the fastest growth, supported by rising surgical volumes and adoption of multimodal pain management.
Market Dynamics
Key Growth Drivers
• Rising global surgical demand across multiple specialties.
• Growing emphasis on opioid-sparing strategies.
• Expansion of ambulatory and outpatient surgeries requiring innovative pain control.
• Technological advances in long-acting anesthetics and device-based solutions.
Key Challenges
• High risk of opioid dependence and misuse.
• Side effects of NSAIDs and local anesthetics in long-term use.
• Limited availability of advanced therapies in developing regions.
• Cost barriers for extended-release and device-based therapies.
Latest Trends
• Development of liposomal and extended-release formulations for long-lasting pain relief.
• Expansion of neuromodulation and non-pharmacological interventions.
• Integration of AI-driven digital monitoring platforms for post-surgical recovery.
• Growth of enhanced recovery after surgery (ERAS) protocols worldwide.
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Competitor Analysis
Major Players
• Pacira BioSciences, Inc. (Exparel - liposomal bupivacaine)
• Pfizer Inc. (opioids, NSAIDs portfolio)
• Teva Pharmaceutical Industries Ltd. (generics in pain management)
• Eli Lilly and Company (pain management research pipeline)
• Novartis AG (oncology-related pain management)
• Johnson & Johnson (device-based and pharmaceutical pain care)
• AbbVie Inc. (analgesics and specialty care portfolio)
• Grünenthal GmbH (pain management specialty company)
• Boston Scientific Corporation (neuromodulation devices)
• Medtronic plc (pain pumps and neuromodulation systems)
Summary:
The market is fragmented, with pharmaceutical giants driving drug innovation, while device companies such as Medtronic and Boston Scientific expand in neuromodulation and advanced pain management.
Conclusion
The postoperative pain market is projected to grow from USD 38.5 billion in 2024 to USD 58.9 billion by 2034, at a CAGR of 4.4%. Rising surgical volumes, opioid-sparing approaches, and innovation in multimodal pain management will shape the market's future.
Key Takeaways:
• North America dominates today, while Asia-Pacific grows fastest.
• Pharmacological therapies remain central, but device-based and non-opioid extended-release therapies are expanding rapidly.
• Challenges include opioid risks, affordability, and uneven access.
• Competitive strategies focus on opioid alternatives, multimodal regimens, and digital monitoring solutions.
Looking ahead, the postoperative pain market will transition toward safer, patient-centered, and technology-integrated approaches, balancing effective analgesia with minimal side effects, ultimately enhancing recovery and quality of life for millions of surgical patients worldwide.
This report is also available in the following languages : Japanese (術後疼痛市場), Korean (수술 후 통증 시장), Chinese (术后疼痛市场), French (Marché de la douleur postopératoire), German (Markt für postoperative Schmerzen), and Italian (Mercato del dolore postoperatorio), etc.
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