Global gRNA Market Size, Share, Forecast 2023 - 2033 | Top key players : Thermo Fisher Scientific Inc., CRISPER QC, Synthego, Merck KGaA, Jena Bioscience GmbH, Agilent Technologies Inc., Takara Bio Inc.

According to a research report published by Spherical Insights & Consulting, the Global gRNA Market Size is to Grow from USD 487.06 Million in 2023 to USD 2679.86 Million by 2033, at a Compound Annual Growth Rate (CAGR) of 18.59% during the projected period.

A specific RNA sequence known as guide RNA (gRNA) designates the region of interest in the target DNA. To transfer the modification, it binds itself to the Cas9 protein and directs it to the desired spot. The guide RNA (gRNA) market is expanding rapidly due to its importance in CRISPR-based genetic engineering. The gRNA is a short RNA sequence that directs Cas9 and other CAS proteins to specific DNA sequences, allowing for precise gene editing. This technology has altered industries such as medicine, agriculture, and biotechnology, making it an essential tool for researchers seeking to modify genes with great accuracy. The increased need for personalized medication is a primary driver of the gRNA market's growth. As healthcare shifts to customized treatments, the requirement for precise genetic changes develops, increasing demand for gRNA-based technology. However, there are risks or downsides to using gRNA, such as mismatches between the gRNA and the area of interest, which can lead to adverse effects depending on their locations and the number of mismatches.

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The products segment is anticipated to grow at the highest CAGR of the gRNA market during the projected timeframe.

Based on the product & services, the gRNA market is divided into products and custom gRNA synthesis services. Among these, the products segment is anticipated to grow at the highest CAGR of the gRNA market during the projected timeframe. This dominance is due to researchers including these products because of their remarkable features, which include excellent specificity, efficiency, and precision in gene editing. In addition to products, the market offers gRNA design, synthesis, and delivery, among other services. With the use of these services, researchers can add unique gRNA sequences and delivery methods to their gene editing experiments, improving the process' precision and specificity.

The research-use segment accounted for the largest revenue share of the gRNA market during the projected timeframe.

Based on the gRNA type, the gRNA market is divided into research-use and GMP-grade. Among these, the research-use segment accounted for the largest revenue share of the gRNA market during the projected timeframe. The advantageous qualities of gRNA make it useful in research. The purpose of modifying gRNA is to increase its efficiency and stability against nuclease destruction. gRNA to increase the stability, safety, specificity, and adaptability of the CRISPR system.

The genome engineering segment dominates the market with the highest market share of the gRNA market during the projected timeframe.

Based on the application, the gRNA market is divided into genome engineering, disease model studies, functional genomics, epigenetics, and others. Among these, the genome engineering segment dominates the market with the highest market share of the gRNA market during the projected timeframe. The CRISPR genome editing technology in genome engineering allows users to create gRNA that targets a specific DNA sequence. Agriculture, biotechnology, infectious disease research, therapeutic medications, and pharmaceuticals all use gRNA applications in genome engineering technologies.

The pharmaceutical & biotechnology companies segment holds the largest market share of the gRNA market during the projected timeframe.

Based on the end-use, the gRNA market is divided into pharmaceutical & biotechnology companies, academic research institutes, and CMOs & CROs. Among these, the pharmaceutical & biotechnology companies segment holds the largest market share of the gRNA market during the projected timeframe. gRNA is widely used in biotechnology and pharmaceutical industries because of its benefits, which include its ability to acquire chemical alterations that aid in preventing the CRISPR machinery from being degraded by the intracellular immune response.

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North America is expected to hold the largest share of the gRNA market over the forecast period.

North America is expected to hold the largest share of the gRNA market over the forecast period. The growth of the gRNA market in the region is attributed to a number of factors, including the presence of a significant number of major players locally, including Merck KGaA and Thermo Fisher Scientific, as well as an increase in research and development spending by major players to create cutting-edge and innovative products.

Asia-Pacific is predicted to grow at the fastest pace in the gRNA market during the projected timeframe. The region's leading manufacturers are expected to have growth opportunities due to factors including the presence of a sizable target market, accelerated adoption of various technologies, multiple startups in conjunction with acquiring healthcare facilities, and a high rate of unmet clinical requirements.

Major vendors in the gRNA market are Thermo Fisher Scientific Inc., CRISPER QC, Synthego, Merck KGaA, Jena Bioscience GmbH, Agilent Technologies Inc., Takara Bio Inc., Mirus Bio LLC, Integrated DNA Technologies, Inc., Mammoth Biosciences, Inc., Horizon Discovery Ltd., System Biosciences, LLC, Synbio Technologies, GENEWIZ (Azenta Life Sciences), and others.

Recent Developments

In April 2024, The AI-first protein design startup Profluent presented the first open-source AI-generated gene editor as part of its OpenCRISPRTM effort. Profluent created the first successful instance of precise editing of the human genome by using artificial intelligence to create fully customizable gene editors from the ground up.

Key Target Audience

Market Players
Investors
End-users
Government Authorities
Consulting And Research Firm
Venture capitalists
Value-Added Resellers (VARs)

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Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2033. Spherical Insights has segmented the gRNA market based on the below-mentioned segments:

Global gRNA Market, By Product & Services

Products
Custom gRNA Synthesis Services

Global gRNA Market, By gRNA Type

Research-Use
GMP-grade

Global gRNA Market, By Application

Genome Engineering
Disease Model Studies
Functional Genomics
Epigenetics
Others

Global gRNA Market, By End-use

Pharmaceutical & Biotechnology Companies
Academic Research Institutes
CMOs & CROs

Global gRNA Market, By Regional Analysis

North America
US
Canada
Mexico

Europe
Germany
UK
France
Italy
Spain
Russia
Rest of Europe

Asia Pacific
China
Japan
India
South Korea
Australia
Rest of Asia Pacific

South America
Brazil
Argentina
Rest of South America

Middle East & Africa
UAE
Saudi Arabia
Qatar
South Africa
Rest of the Middle East & Africa

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