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Human Immunodeficiency Virus Type 1 (HIV-1) Market is expected to reach USD 44.7 billion by 2034

09-10-2025 12:10 PM CET | Health & Medicine

Press release from: Exactitude Consultancy

Human Immunodeficiency Virus Type

Human Immunodeficiency Virus Type

Human Immunodeficiency Virus Type 1 (HIV-1) remains a major global health challenge, responsible for the vast majority of HIV infections worldwide. While it is no longer the fatal disease it once was, thanks to antiretroviral therapy (ART), HIV-1 remains incurable and requires lifelong management. Patients benefit today from once-daily oral regimens, long-acting injectables, and pre-exposure prophylaxis (PrEP) to prevent transmission.

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The HIV-1 market continues to evolve, driven by innovation in long-acting therapies, two-drug regimens, and global initiatives to expand testing and treatment access. With pipeline research exploring vaccines, broadly neutralizing antibodies (bNAbs), and potential cures, the next decade promises both growth and disruption.

Market Overview
• Market Size (2024): USD 28.4 billion
• Forecast (2034): USD 44.7 billion
• CAGR (2025-2034): 4.6%

The market remains robust, fueled by rising HIV prevalence in low- and middle-income countries, expanded global ART programs, and innovation in long-acting injectable treatments.

Key Highlights:
• Over 39 million people globally live with HIV, with HIV-1 accounting for ~95% of cases.
• ART has transformed HIV-1 into a manageable chronic condition.
• FDA and EMA approvals of long-acting injectables (cabotegravir/rilpivirine) mark a paradigm shift.
• Strong research in vaccines, cure strategies, and bNAbs.

Segmentation Analysis
By Product Type:
• Antiretroviral Therapy (ART)
o Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
o Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
o Protease Inhibitors (PIs)
o Integrase Strand Transfer Inhibitors (INSTIs)
o Entry Inhibitors (CCR5 antagonists, fusion inhibitors)
• Long-Acting Injectables
o Cabotegravir + Rilpivirine (Cabenuva)
o Lenacapavir (pipeline)
• Pre-Exposure Prophylaxis (PrEP)
o Tenofovir/Emtricitabine (Truvada, Descovy)
o Long-acting PrEP (cabotegravir)
• Pipeline Therapies
o Vaccines (mRNA-based, viral vector)
o Broadly Neutralizing Antibodies (bNAbs)
o Gene Editing & Cure Research

By Platform:
• Small Molecules
• Biologics
• Gene Therapy Research

By Technology:
• Antiviral Drug Development Platforms
• Long-Acting Injectable Delivery Systems
• Vaccine and bNAb Engineering
• AI-Based Drug Discovery

By End Use:
• Hospitals
• Specialty Infectious Disease Clinics
• Research Institutes
• Home Care (self-administered ART, telehealth)

By Application:
• Treatment of HIV-1 Infection
• Prevention (PrEP)
• Clinical Research for Cure & Vaccines

Segmentation Summary:
ART dominates the market, but long-acting injectables and PrEP are reshaping prevention and adherence strategies. Pipeline innovations in vaccines and bNAbs represent the most disruptive future opportunity.

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Regional Analysis
North America
• Largest market with ~44% share in 2024.
• Strong ART adoption and early launch of long-acting injectables.
• Robust R&D ecosystem with ongoing vaccine trials.
Europe
• Holds ~30% share.
• Germany, UK, and France lead in adoption of new regimens.
• EMA-approved PrEP expansion improving prevention strategies.
Asia-Pacific
• Fastest-growing region with CAGR of ~6.0%.
• High HIV prevalence in India, China, and Southeast Asia.
• Expanding ART access through government and NGO programs.
Middle East & Africa
• Highest disease burden but limited access to advanced therapies.
• Global aid programs (PEPFAR, Global Fund) expanding ART coverage.
Latin America
• Brazil and Mexico lead in ART coverage and PrEP adoption.
• Increasing role of government-funded HIV initiatives.
Regional Summary:
North America and Europe dominate in innovation and early adoption, while Asia-Pacific grows fastest due to expanding ART coverage. Africa remains a major focus for global aid-driven HIV care expansion.

Market Dynamics
Key Growth Drivers:
• Rising global HIV-1 prevalence.
• Expanding ART and PrEP adoption.
• Long-acting injectables improving adherence.
• Strong vaccine and cure research pipelines.

Key Challenges:
• High cost of new therapies in low-income regions.
• Stigma and underdiagnosis in many parts of the world.
• Drug resistance with long-term ART use.
• Complex logistics of ART access in rural/remote areas.

Latest Trends:
• Approval of Cabenuva, the first long-acting injectable ART regimen.
• mRNA-based HIV vaccine research inspired by COVID-19 vaccine success.
• bNAbs showing promise for prevention and functional cure.
• Digital adherence monitoring and telehealth integration.

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Competitor Analysis
Major Players in the Market:
• Gilead Sciences, Inc. (Biktarvy, Descovy, Truvada)
• ViiV Healthcare (GSK + Pfizer + Shionogi) (Cabenuva, Triumeq, Dovato)
• Johnson & Johnson (Janssen Pharmaceuticals)
• Merck & Co., Inc. (Isentress, Doravirine)
• Roche Holding AG
• Moderna, Inc. (mRNA-based HIV vaccine pipeline)
• BioNTech SE (vaccine development)
• AbbVie Inc.
• Cipla Ltd. (generic ART leadership)
• Lupin Limited

Competitive Summary:
Gilead and ViiV Healthcare dominate the ART and PrEP markets, while J&J and Merck remain strong in integrase and NNRTI segments. Moderna and BioNTech are advancing HIV vaccines. Generics players like Cipla and Lupin provide affordable ART access globally.

Conclusion
The HIV-1 Market, valued at USD 28.4 billion in 2024, is projected to reach USD 44.7 billion by 2034, growing at a CAGR of 4.6%. Expanding ART access, innovation in long-acting injectables, and strong vaccine and cure pipelines will continue to shape the global HIV landscape.

Key Takeaways:
• ART remains the backbone of treatment, but injectables are the biggest innovation.
• North America and Europe dominate in innovation, while Asia-Pacific grows fastest.
• Africa remains the highest-need region, supported by global aid.
• Vaccines, bNAbs, and gene editing hold future curative potential.

The next decade will redefine HIV-1 management, transitioning from lifelong oral therapy to long-acting injectables, preventive vaccines, and functional cure research, creating opportunities for pharma innovators and healthcare providers.

This report is also available in the following languages : Japanese (ヒト免疫不全ウイルス1型(HIV-1)市場), Korean (인간 면역 결핍 바이러스 1형(HIV-1) 시장), Chinese (人类免疫缺陷病毒 1 型(HIV-1)市场), French (Marché du virus de l'immunodéficience humaine de type 1 (VIH-1)), German (Markt für das humane Immundefizienzvirus Typ 1 (HIV-1)), and Italian (Mercato del virus dell'immunodeficienza umana di tipo 1 (HIV-1)), etc.

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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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