Intratumoral Cancer therapies Market Outlook 2034 - Clinical Trials, Market Size, Medication, Prevalence, Companies by DelveInsight

Intratumoral Cancer Market Summary
Intratumoral cancer therapies involve direct delivery into tumors, enabling localized targeting with minimal damage to surrounding tissue. Within the 7MM, non-melanoma cancers represent the largest share of cases and are expected to rise at ~2% annually, while in the US, breast cancer accounts for about 30% of cases with a growing incidence rate for intratumoral therapies. Currently, IMLYGIC is the only FDA-approved intratumoral therapy for melanoma, holding over 90% market share. Multiple approaches-such as cytokine modulators, TLR/STING agonists, checkpoint inhibitors, cytokine traps, oncolytic viruses, and plasmid DNA-are in development, particularly for melanoma. Among pipeline therapies, OncoSec's TAVO (IL-12 plasmid-based therapy) is anticipated to drive the highest revenues. The field is advancing rapidly, supported by major pharma players like Nanobiotix, Replimune, and Sirnaomics. Key players in the Intratumoral Cancer Therapies segment include Amgen, Daiichi Sankyo, AiViva BioPharma, Lytix Biopharma, Regeneron Pharmaceuticals, Checkmate Pharmaceuticals, OncoSec Medical Incorporated, Merck, Istari Oncology, Replimune, Philogen, Sirnaomics, Exicure, Intensity Therapeutics, NanOlogy, Nanobiotix, Immunovative Therapies, DNAtrix, Idera Pharmaceuticals, Lokon Pharma, Treovir, Immunicum, among others.

DelveInsight has published its latest report, "Intratumoral Cancer Therapies Market Insights, Epidemiology, and Market Forecast - 2034," delivering a comprehensive evaluation of the global landscape for Intratumoral Cancer Therapies. The study encompasses both historical data and future epidemiology projections, as well as market dynamics across the United States, EU4 (Germany, Spain, Italy, France, and the United Kingdom), and Japan. The analysis offers insights into present-day treatment strategies, newly emerging therapies, market share by product, and market size forecasts from 2020 through 2034 across the seven key regions. Additionally, it examines treatment algorithms, driving factors, restraints, unmet medical needs, and opportunities shaping the future of the intratumoral therapy market.

For detailed insights into the market outlook, therapy adoption, treatment landscape, and epidemiology trends, visit: Intratumoral Cancer Therapies Market Forecast - https://www.delveinsight.com/sample-request/intratumoral-cancer-therapies-market-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

Key Highlights of the Intratumoral Cancer Therapies Market Report
• The Intratumoral Cancer Therapies market is projected to expand at a strong CAGR throughout 2020-2034.
• In January 2025, Intensity Therapeutics, Inc. (NASDAQ: INTS) provided a corporate update highlighting substantial progress for its lead immuno-oncology asset INT230-6.
• In January 2025, Lokon Pharma AB announced that the US FDA granted Fast Track status to its candidate LOAd703 for pancreatic cancer.
• In March 2024, ImmVira revealed that its oncolytic virus MVR-T3011 IT was awarded FDA Fast Track Designation for recurrent/metastatic head and neck squamous cell carcinoma resistant to platinum chemotherapy and anti-PD1/PD-L1 therapies.
• Various investigational strategies-cytokine-based immune enhancers, TLR/STING agonists, checkpoint inhibitors, inhibitory cytokine traps, plasmid DNA approaches, and oncolytic viruses (OVs)-are advancing in trials for melanoma.
• IMLYGIC remains the only FDA-approved intratumoral therapy for melanoma, representing 90%+ of market share.
• Among upcoming drugs, OncoSec Medical's TAVO (plasmid IL-12) is predicted to capture the highest commercial revenue.
• The United States contributes nearly 80% of the total market value.
• Survival in cutaneous melanoma improves dramatically with early detection-81.6% localized diagnosis (99.5% 5-year survival), 9% regional, and 4% distant-stage cases.
• Between 2021-2022, the US recorded 98,046 melanoma cases, a figure projected to climb by 2032. In Germany, 2021 data showed 31,636 melanoma cases and 91,650 non-melanoma skin cancer (NMSC) cases.
• NMSC accounts for the largest share among nine main indications, with 793,007 cases across the 7MM in 2021.

Intratumoral Cancer Competitive Landscape
Notable Companies Active in the Intratumoral Cancer Space
Amgen, Daiichi Sankyo, AiViva BioPharma, Lytix Biopharma, Regeneron Pharmaceuticals, Checkmate Pharmaceuticals, OncoSec Medical Incorporated, Merck, Istari Oncology, Replimune, Philogen, Sirnaomics, Exicure, Intensity Therapeutics, NanOlogy, Nanobiotix, Immunovative Therapies, DNAtrix, Idera Pharmaceuticals, Lokon Pharma, Treovir, Immunicum, and more.

Prominent Therapies in Development & Use
• IMLYGIC (talimogene laherparepvec): Amgen
• DELYTACT (G47Δ): Daiichi Sankyo
• AIV001: AiViva BioPharma
• LTX-315: Lytix Biopharma
• Vidutolimod + nivolumab: Regeneron Pharmaceuticals
• Vidutolimod (CMP-001): Checkmate Pharmaceuticals
• TAVO (tavokinogene telseplasmid): OncoSec Medical Incorporated
• CAVATAK (V937; CVA21): Merck
• PVSRIPO (PVS-RIPO): Istari Oncology
• RP1 (vusolimogene oderparepvec): Replimune / Regeneron
• Daromun (Nidlegy): Philogen
• Cotsiranib (STP705): Sirnaomics
• Cavrotolimod (AST-008): Exicure
• INT230-6 (cisplatin/vinblastine): Intensity Therapeutics
• NanoPac (LSAM paclitaxel): NanOlogy
• Hensify (NBTXR3/PEP503): Nanobiotix
• AlloStim: Immunovative Therapies
• Tasadenoturev (DNX-2401): DNAtrix
• Tilsotolimod (IMO-2125): Idera Pharmaceuticals
• Delolimogene mupadenorepvec (LOAd703): Lokon Pharma
• G207: Treovir
• Intuvax (Ilixadencel): Immunicum

Learn more about therapies expected to dominate the market: Intratumoral Cancer Treatment Market - https://www.delveinsight.com/report-store/intratumoral-cancer-therapies-market-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

Intratumoral Cancer Therapies - Market & Clinical Insights
The intratumoral cancer therapies market is projected for strong growth, driven by rising cancer diagnoses, increasing awareness, and a robust pipeline of investigational therapies. Currently, IMLYGIC (US, EU) and DELYTACT (Japan) are the only approved therapies, with IMLYGIC dominating the market. Emerging candidates like vidutolimod and RP1 are expected to reshape the landscape in the next decade.

Key developers include Nanobiotix, Sirnaomics, and Replimune. While melanoma leads in revenue generation, non-melanoma skin cancers are poised to become major future targets. Geographically, the US holds about 80% of market share, while within Europe, Germany leads, followed by France, with Spain holding the lowest share.

Intratumoral therapies involve direct delivery of agents into the tumor microenvironment, allowing for high local efficacy with minimal systemic toxicity. This method enhances immune activation, can induce systemic responses (abscopal effect), and is increasingly being investigated across cancers like melanoma, HNSCC, and triple-negative breast cancer.

Challenges include standardizing administration protocols, ensuring tumor accessibility, and optimizing delivery platforms. However, ongoing innovations are expected to reshape this therapeutic domain.

Download a complimentary sample of the Intratumoral Cancer Therapies Market Report: https://www.delveinsight.com/sample-request/intratumoral-cancer-therapies-market-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

Intratumoral Cancer therapies Market Drivers
• Rising Cancer Incidence - Growing global cancer prevalence, especially skin cancers like melanoma and non-melanoma, is boosting demand for novel treatments.
• Targeted Localized Therapy - Direct tumor injection minimizes systemic toxicity while enhancing efficacy, increasing physician and patient interest.
• Strong Pipeline - Multiple innovative therapies (oncolytic viruses, cytokines, plasmid DNA, checkpoint inhibitors) are in late-stage trials.
• Regulatory Support - FDA Fast Track and EMA orphan drug designations are accelerating development timelines.
• Growing Awareness & Adoption - Increased understanding of intratumoral therapy benefits among clinicians and patients is driving uptake.
• Combination Therapy Potential - Synergies with immune checkpoint inhibitors and radiotherapy enhance treatment outcomes.
• High US Market Share - The United States accounts for ~80% of the market, supported by advanced healthcare infrastructure and rapid adoption of novel therapies.
• Strong Industry Involvement - Leading companies like Amgen, Nanobiotix, Replimune, Merck, and Sirnaomics are investing heavily in R&D and partnerships.

Intratumoral Cancer therapies Market Barriers
• Limited Approved Therapies - Currently, only IMLYGIC (FDA-approved) and DELYTACT (Japan-approved) are on the market, restricting immediate adoption.
• High Development Costs - Complex trial designs and intratumoral delivery requirements increase R&D expenditure.
• Tumor Accessibility Challenges - Certain cancers are difficult to treat with intratumoral injections due to location and size.
• Standardization Issues - Lack of unified administration protocols and optimal dosing strategies limits broader clinical use.
• Safety & Efficacy Concerns - Some therapies show variable results, with uncertainties around long-term outcomes.
• Reimbursement Hurdles - High therapy costs and evolving payer perspectives may restrict patient access in some regions.
• Competition from Established Modalities - Systemic immunotherapies and targeted drugs remain first-line options, slowing intratumoral adoption.
• Limited Awareness in Developing Markets - Lower oncologist familiarity and weak infrastructure reduce penetration outside the US and EU.

Intratumoral Cancer Therapies Epidemiology Insights
The epidemiology section provides historic, current, and forecasted trends across the 7MM between 2020 and 2034, exploring prevalence, diagnosis rates, gender distribution, and disease severity.
Segmentation covers:
• Total prevalence
• Severity-specific prevalence
• Gender-specific prevalence
• Chronic vs. episodic diagnosed cases

Intratumoral Cancer Drug Uptake & Pipeline Activities
HENSIFY (NBTXR3) - Nanobiotix
HENSIFY, developed by Nanobiotix, is a first-in-class intratumoral therapy that physically destroys tumors and stimulates the immune system when combined with radiation. It consists of hafnium oxide nanoparticles injected into tumors prior to radiotherapy, amplifying the tumor-killing effect of X-rays without increasing damage to healthy tissue. Currently in Phase III trials for head and neck squamous cell carcinoma, NBTXR3 is also being explored in lung, liver, prostate, and other cancers. In February 2020, the FDA granted Fast Track Designation for its use with or without cetuximab in locally advanced head and neck cancers unsuitable for platinum-based chemotherapy.

STP705 (cotsiranib) - Sirnaomics
STP705 is Sirnaomics' lead siRNA therapy that simultaneously inhibits TGF-β1 and COX-2 using nanoparticle-enhanced delivery. It is in late-stage trials for squamous cell carcinoma in situ, Phase II for basal cell carcinoma, and Phase I for fat remodeling. Additionally, it holds Orphan Drug Designation for cholangiocarcinoma (CCA) and primary sclerosing cholangitis (PSC).

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Scope of the Intratumoral Cancer therapies Market Report
• Study Timeline: 2020-2034
• Geographies Covered: US, EU5 (Germany, France, Italy, Spain, UK), and Japan
• Therapies: IMLYGIC, DELYTACT, AIV001, LTX-315, Vidutolimod, TAVO, CAVATAK, RP1, PVSRIPO, Daromun, and others
• Assessments: Current vs. pipeline therapies, unmet needs, SWOT, PESTLE, Porter's Five Forces, BCG Matrix, reimbursement, and KOL perspectives

Contact Us:
Ankit Nigam
Manager Marketing
info@delveinsight.com
+14699457679

About DelveInsight
DelveInsight is a leading Life Science market research and business consulting company recognized for its off-the-shelf syndicated market research reports and customized solutions to firms in the healthcare sector.

This release was published on openPR.