Desmoid Tumors Market to Expand Significantly by 2034, States DelveInsight Report

DelveInsight's "Desmoid Tumors Market Insights, Epidemiology, and Market Forecast-2034′′ report offers an in-depth understanding of the Desmoid Tumors, historical and forecasted epidemiology as well as the Desmoid Tumors market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan.

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Some of the key facts of the Desmoid Tumors Market Report:
• The Desmoid Tumors market size was valued ~USD 89 million in 2023 and is anticipated to grow with a significant CAGR during the study period (2020-2034).
• In November 2025, Parabilis Medicines, a clinical-stage biopharmaceutical company dedicated to developing innovative therapies for cancer patients, announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to FOG-001 for treating desmoid tumors. This recognition highlights the significant unmet medical need and the potential of this first-in-class therapy to improve patient outcomes. FOG-001, Parabilis's lead investigational Helicon peptide, is the first and only direct inhibitor targeting the previously "undruggable" β-catenin:TCF interaction.
• In 2023, the United States held the largest market size for Desmoid Tumors among the seven major markets (7MM), valued at approximately USD 60 million.
• In 2023, there were approximately 3,400 new cases of desmoid tumors across the seven major markets (7MM), with the United States reporting the highest number of these incident cases.
• In 2023, mutation-specific desmoid tumor cases in the seven major markets (7MM) were predominantly driven by CTNNB1 gene mutations, accounting for nearly 28,400 cases, whereas APC gene mutations were associated with around 3,000 cases.
• In 2023, the United States held the largest share of the desmoid tumors market among the seven major markets (7MM), representing about 68% of the total market.
• Desmoid tumors make up less than 3% of all soft tissue tumors, with an estimated annual incidence ranging from 1 in 250,000 to 1 in 500,000.
• In the United States, approximately 1,000 to 1,650 new cases of desmoid tumors are diagnosed each year.
• In 2023, the 10-year prevalence of desmoid tumors in the EU4 and the UK was approximately 4,500 cases among males and 8,300 cases among females.
• Major companies in the desmoid tumors space, including SpringWorks Therapeutics (OGSIVEO [nirogacestat]), Immunome/Ayala Pharmaceuticals (AL102), Iterion Therapeutics and Apollomics (Tegavivint [BC2059]), Eisai and PRISM BioLab (E7386), among others, are currently advancing their lead candidates through various stages of clinical development. These developments are expected to have a significant impact on the desmoid tumors market throughout the forecast period from 2024 to 2034.
• The desmoid tumors pipeline is relatively limited and includes therapies such as Gamma Secretase Inhibitors (GSI), TBL1 inhibitors, CBP/ß-catenin interaction inhibitors, and other treatments.
• Key Desmoid Tumors Companies: SpringWorks Therapeutics, Immunome/Ayala Pharmaceuticals, Iterion Therapeutics, Eisai and PRISM BioLab, MedPacto, Inc., Pfizer, Novartis, Ayala Pharmaceuticals, Iterion Therapeutics, Aadi Bioscience, Inc., INSYS Therapeutics Inc, Recursion Pharmaceuticals Inc, and others
• Key Desmoid Tumors Therapies: OGSIVEO (nirogacestat), AL102, Tegavivint (BC2059), E7386, Vactosertib, Sirolimus, Imatinib, AL102, Tegavivint, Nab-Rapamycin, Fentanyl sublingual spray, REC-4881, and others
• The Desmoid Tumors epidemiology based on gender analyzed that Desmoid Tumors are more common in women as compared to men
• The Desmoid Tumors market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Desmoid Tumors pipeline products will significantly revolutionize the Desmoid Tumors market dynamics.

Desmoid Tumors Overview
Desmoid tumors, also known as aggressive fibromatosis, are rare, slow-growing tumors that develop from the connective tissue cells in the body. These tumors are typically noncancerous (benign), but they can be locally aggressive, meaning they may invade and destroy surrounding tissue, organs, or structures.

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Desmoid Tumors Epidemiology
The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2020 to 2034. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. The epidemiology section also provides a detailed analysis of the diagnosed patient pool and future trends.

Desmoid Tumors Epidemiology Segmentation:
The Desmoid Tumors market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
• Total Prevalence of Desmoid Tumors
• Prevalent Cases of Desmoid Tumors by severity
• Gender-specific Prevalence of Desmoid Tumors
• Diagnosed Cases of Episodic and Chronic Desmoid Tumors

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Desmoid Tumors Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Desmoid Tumors market or expected to get launched during the study period. The analysis covers Desmoid Tumors market uptake by drugs, patient uptake by therapies, and sales of each drug.
Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.
The report also covers the Desmoid Tumors Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Desmoid Tumors Therapies and Key Companies
• OGSIVEO (nirogacestat): SpringWorks Therapeutics
• AL102: Immunome/Ayala Pharmaceuticals
• Tegavivint (BC2059): Iterion Therapeutics
• E7386: Eisai and PRISM BioLab
• Vactosertib: MedPacto, Inc.
• AL102: Ayala Pharmaceuticals
• Tegavivint: Iterion Therapeutics
• Sirolimus: Pfizer
• Imatinib: Novartis
• Nab-Rapamycin: Aadi Bioscience, Inc.
• Fentanyl sublingual spray: INSYS Therapeutics Inc
• REC-4881: Recursion Pharmaceuticals Inc.

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Desmoid Tumors Market Drivers
• Desmoid Tumors is a rare form of cancer; thus, companies developing treatment options for the same can possess several advantages like market exclusivities, premium pricing, subsidy for conducting trials, and several other benefits from the government bodies for R&D.

Desmoid Tumors Market Barriers
• Lack of approved therapies indicate an opportune time to invest in research and development as the Desmoid Tumors therapy segment is currently being explored by only a handful of players.

Scope of the Desmoid Tumors Market Report
• Study Period: 2020-2034
• Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan]
• Key Desmoid Tumors Companies: SpringWorks Therapeutics, Immunome/Ayala Pharmaceuticals, Iterion Therapeutics, Eisai and PRISM BioLab, MedPacto, Inc., Pfizer, Novartis, Ayala Pharmaceuticals, Iterion Therapeutics, Aadi Bioscience, Inc., INSYS Therapeutics Inc, Recursion Pharmaceuticals Inc., and others
• Key Desmoid Tumors Therapies: OGSIVEO (nirogacestat), AL102, Tegavivint (BC2059), E7386, Vactosertib, Sirolimus, Imatinib, AL102, Tegavivint, Nab-Rapamycin, Fentanyl sublingual spray, REC-4881, and others
• Desmoid Tumors Therapeutic Assessment: Desmoid Tumors current marketed and Desmoid Tumors emerging therapies
• Desmoid Tumors Market Dynamics: Desmoid Tumors market drivers and Desmoid Tumors market barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Desmoid Tumors Unmet Needs, KOL's views, Analyst's views, Desmoid Tumors Market Access and Reimbursement

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About DelveInsight
DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.
It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach.

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