Myelin Regeneration in Multiple Sclerosis Clinical Trials, Companies, Therapeutic Assessment, Therapies, Pipeline | Arcus Biosciences, Akeso Biopharma, Biotheus, GlaxoSmithKline, AstraZeneca, Pfizer,

DelveInsight's, "PD-1 Non-Small Cell Lung Cancer (PD-1+ NSCLC) - Pipeline Insight, 2025" report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in PD-1 Non-Small Cell Lung Cancer (PD-1+ NSCLC) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type.
According to DelveInsight, the Myelin Regeneration in Multiple Sclerosis pipeline comprises over 25 key companies actively developing more than 30 therapies aimed at treating multiple sclerosis.

Myelin Regeneration in Multiple Sclerosis Overview:

Lung cancer continues to be a leading cause of cancer-related mortality worldwide, often associated with a poor prognosis. The advent of immune checkpoint inhibitors targeting programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) has notably reshaped the treatment landscape for patients with non-small cell lung cancer (NSCLC). Blocking the PD-1 receptor and its ligand PD-L1 has shown robust therapeutic effects and improved survival outcomes in both preclinical and clinical studies, particularly for patients with locally advanced or metastatic NSCLC.

PD-1 is a Type I transmembrane protein expressed on T cells, B cells, natural killer (NK) cells, activated monocytes, and dendritic cells (DCs). Its ligands, PD-L1 and PD-L2, are also Type I transmembrane proteins but differ in expression patterns. PD-L1 is found on T cells, B cells, DCs, macrophages, various non-hematopoietic cells, and tumor cells. Structurally, PD-1 and its ligands contain a signal sequence, an immunoglobulin (Ig) domain, transmembrane domains, and a short cytoplasmic tail.

When PD-1 binds to PD-L1 or PD-L2, it undergoes phosphorylation at two intracellular tyrosine residues, leading to the recruitment of SHP-1 and SHP-2 phosphatases, which interact with the ITIM and ITSM motifs of PD-1. This signaling cascade ultimately suppresses antigen receptor signaling. While PD-1 engagement inhibits effector T-cell function, the interaction of B7-1/B7-2 with CD28 promotes T-cell proliferation, highlighting the contrasting roles of these pathways in immune regulation.

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"Myelin Regeneration in Multiple Sclerosis Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Myelin Regeneration in Multiple Sclerosis Therapeutics Market.

Key Takeaways from the Myelin Regeneration in Multiple Sclerosis Pipeline Report

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DelveInsight's Myelin Regeneration in Multiple Sclerosis pipeline report highlights a dynamic landscape, featuring over 25 active companies working on more than 30 therapies aimed at enhancing myelin repair in Multiple Sclerosis.

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Key players in this space include Arcus Biosciences, Akeso Biopharma, Biotheus, GlaxoSmithKline, AstraZeneca, Pfizer, Shandong Boan Biotechnology, Genor Biopharma, and others, all developing innovative treatments to improve the MS therapy landscape.

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Promising pipeline candidates at various stages of development include Zimberelimab, PM8002, RPH075, among others.

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In recent regulatory updates, AstraZeneca's durvalumab received FDA approval in August 2024 for treating adult patients with NSCLC post-surgery, extending its use beyond late-stage cases where surgery was previously not an option. Additionally, in January 2023, pembrolizumab was approved by the FDA as an adjuvant therapy following surgical resection and platinum-based chemotherapy for patients with stage IB (T2a greater than or equal to 4 cm), II, or IIIA NSCLC.

Myelin Regeneration in Multiple Sclerosis Pipeline Analysis

The report provides insights into:

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The report provides detailed insights into the key companies that are developing therapies in the Myelin Regeneration in Multiple Sclerosis Market.

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The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Myelin Regeneration in Multiple Sclerosis treatment.

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It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.

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It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.

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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Myelin Regeneration in Multiple Sclerosis market.

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Myelin Regeneration in Multiple Sclerosis Emerging Drugs

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Zimberelimab: Arcus Biosciences

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PM8002: Biotheus

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RPH075: R-Pharm

Myelin Regeneration in Multiple Sclerosis Companies

Over 25 key companies are actively working on therapies for PD-1-positive Non-Small Cell Lung Cancer (PD-1+ NSCLC), with Arcus Biosciences having candidates in the most advanced stage of development, currently in Phase III trials.

DelveInsight's report covers around 30+ products under different phases of clinical development like

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Late stage products (Phase III)

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Mid-stage products (Phase II)

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Early-stage product (Phase I) along with the details of

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Pre-clinical and Discovery stage candidates

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Discontinued & Inactive candidates

Myelin Regeneration in Multiple Sclerosis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

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Intravenous

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Subcutaneous

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Oral

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Intramuscular

Myelin Regeneration in Multiple Sclerosis Products have been categorized under various Molecule types such as

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Monoclonal antibody

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Small molecule

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Peptide

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Myelin Regeneration in Multiple Sclerosis Pipeline Therapeutic Assessment

- Myelin Regeneration in Multiple Sclerosis Assessment by Product Type

- Myelin Regeneration in Multiple Sclerosis By Stage

- Myelin Regeneration in Multiple Sclerosis Assessment by Route of Administration

- Myelin Regeneration in Multiple Sclerosis Assessment by Molecule Type

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Table of Content

1. Report Introduction

2. Executive Summary

3. Myelin Regeneration in Multiple Sclerosis Current Treatment Patterns

4. Myelin Regeneration in Multiple Sclerosis - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Myelin Regeneration in Multiple Sclerosis Late-Stage Products (Phase-III)

7. Myelin Regeneration in Multiple Sclerosis Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Myelin Regeneration in Multiple Sclerosis Discontinued Products

13. Myelin Regeneration in Multiple Sclerosis Product Profiles

14. Myelin Regeneration in Multiple Sclerosis Key Companies

15. Myelin Regeneration in Multiple Sclerosis Key Products

16. Dormant and Discontinued Products

17. Myelin Regeneration in Multiple Sclerosis Unmet Needs

18. Myelin Regeneration in Multiple Sclerosis Future Perspectives

19. Myelin Regeneration in Multiple Sclerosis Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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