Extensive-Stage Small Cell Lung Cancer (ESCLC) Clinical Trials, Companies, Therapies, Pipeline | Shanghai Henlius Biotech, MacroGenics, Inc., RayzeBio, Inc., Genentech, Eli Lilly and Company, Amgen

DelveInsight's, "Extensive-Stage Small Cell Lung Cancer (ESCLC) - Pipeline Insight, 2025" report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in Extensive-Stage Small Cell Lung Cancer (ESCLC) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type.
DelveInsight reports that the Extensive-Stage Small Cell Lung Cancer (ESCLC) pipeline involves over 25 key companies actively developing more than 30 investigational therapies.

Extensive-Stage Small Cell Lung Cancer (ESCLC) Overview:

Extensive-Stage Small Cell Lung Cancer (ESCLC) is an aggressive type of lung cancer characterized by rapid progression and early spread to distant organs. Unlike non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) accounts for roughly 10-15% of all lung cancers and has a strong association with smoking. In ESCLC, the cancer has extended beyond the lungs and regional lymph nodes, commonly affecting the liver, bone marrow, brain, and adrenal glands. Patients often present with nonspecific symptoms, including persistent cough, chest pain, shortness of breath, and hemoptysis (coughing up blood). Due to widespread disease, systemic symptoms such as weight loss, fatigue, and loss of appetite are frequent. Paraneoplastic syndromes may also arise from the immune system's response to cancer, leading to conditions like SIADH (syndrome of inappropriate antidiuretic hormone secretion), Cushing's syndrome, or Lambert-Eaton myasthenic syndrome.

Prolonged tobacco use is the primary risk factor for ESCLC, with the likelihood of developing SCLC increasing with the intensity of smoking. The disease originates from uncontrolled growth of neuroendocrine cells in the lungs, forming rapidly expanding tumors that invade nearby tissues and metastasize early. Genetic alterations in tumor suppressor genes such as TP53 and RB1 are commonly linked to SCLC development.

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"Extensive-Stage Small Cell Lung Cancer (ESCLC) Pipeline Insight 2025" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Extensive-Stage Small Cell Lung Cancer (ESCLC) Therapeutics Market.

Key Takeaways from the Extensive-Stage Small Cell Lung Cancer (ESCLC) Pipeline Report

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DelveInsight's Extensive-Stage Small Cell Lung Cancer (ESCLC) pipeline report highlights a dynamic landscape, with over 25 companies actively developing more than 30 investigational therapies for ESCLC treatment.

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Key players in this space include Shanghai Henlius Biotech, MacroGenics, Inc., RayzeBio, Inc., Genentech, Eli Lilly and Company, Amgen, Hutchison Medipharma Limited, Biocity Biopharmaceutics Co., Ltd., Biotheus Inc., GSK, InxMed (Shanghai) Co., Ltd., Daiichi Sankyo, Merck Sharp & Dohme LLC, and others, all working to advance new treatment options for ESCLC. Promising pipeline candidates in various stages of development include Serplulimab combined with chemotherapy, Vobramitamab duocarmazine (MGC018), RYZ101, among others.

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In October 2024, Zai Lab reported promising results for its antibody-drug conjugate, ZL-1310, in ESCLC. Among 19 evaluable patients, 74% responded to treatment, with nine responses still awaiting confirmation. The company plans to optimize dosing between late 2024 and early 2025.

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Additionally, on May 16, 2024, the FDA granted accelerated approval to tarlatamab-dlle (Imdelltra) for patients with ES-SCLC who progressed following platinum-based chemotherapy. This approval was supported by a study showing a 40% overall response rate, with a median duration of response of 9.7 months. Notably, patients with platinum-resistant SCLC achieved a 52% response rate. Common side effects included cytokine release syndrome, fatigue, and nausea.

Extensive-Stage Small Cell Lung Cancer (ESCLC) Pipeline Analysis

The report provides insights into:

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The report provides detailed insights into the key companies that are developing therapies in the Extensive-Stage Small Cell Lung Cancer (ESCLC) Market.

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The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Extensive-Stage Small Cell Lung Cancer (ESCLC) treatment.

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It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.

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It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.

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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Extensive-Stage Small Cell Lung Cancer (ESCLC) market.

Download our free sample page report on Extensive-Stage Small Cell Lung Cancer (ESCLC) pipeline insights [https://www.delveinsight.com/sample-request/extensive-stage-small-cell-lung-cancer-esclc-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Extensive-Stage Small Cell Lung Cancer (ESCLC) Emerging Drugs

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Serplulimab+Chemo: Shanghai Henlius Biotech

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Vobramitamab duocarmazine (MGC018): MacroGenics, Inc.

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RYZ101: RayzeBio, Inc.

Extensive-Stage Small Cell Lung Cancer (ESCLC) Companies

Over 25 leading companies are actively working on therapies for Extensive-Stage Small Cell Lung Cancer (ESCLC), with Shanghai Henlius Biotech having the most advanced candidate currently in Phase III clinical trials.

DelveInsight's report covers around 30+ products under different phases of clinical development like

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Late stage products (Phase III)

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Mid-stage products (Phase II)

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Early-stage product (Phase I) along with the details of

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Pre-clinical and Discovery stage candidates

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Discontinued & Inactive candidates

Extensive-Stage Small Cell Lung Cancer (ESCLC) pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

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Intravenous

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Subcutaneous

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Oral

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Intramuscular

Extensive-Stage Small Cell Lung Cancer (ESCLC) Products have been categorized under various Molecule types such as

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Monoclonal antibody

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Small molecule

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Peptide

Download Sample Pages to Get an in-depth Assessment of the Emerging Extensive-Stage Small Cell Lung Cancer (ESCLC) Therapies and Key Companies: Extensive-Stage Small Cell Lung Cancer (ESCLC) Clinical Trials and advancements [https://www.delveinsight.com/report-store/extensive-stage-small-cell-lung-cancer-esclc-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Extensive-Stage Small Cell Lung Cancer (ESCLC) Pipeline Therapeutic Assessment

- Extensive-Stage Small Cell Lung Cancer (ESCLC) Assessment by Product Type

- Extensive-Stage Small Cell Lung Cancer (ESCLC) By Stage

- Extensive-Stage Small Cell Lung Cancer (ESCLC) Assessment by Route of Administration

- Extensive-Stage Small Cell Lung Cancer (ESCLC) Assessment by Molecule Type

Download Extensive-Stage Small Cell Lung Cancer (ESCLC) Sample report to know in detail about the Extensive-Stage Small Cell Lung Cancer (ESCLC) treatment market @ Extensive-Stage Small Cell Lung Cancer (ESCLC) Therapeutic Assessment [https://www.delveinsight.com/sample-request/extensive-stage-small-cell-lung-cancer-esclc-pipeline-insight?utm_source=abnewswire&utm_medium=market&utm_campaign=kpr]

Table of Content

1. Report Introduction

2. Executive Summary

3. Extensive-Stage Small Cell Lung Cancer (ESCLC) Current Treatment Patterns

4. Extensive-Stage Small Cell Lung Cancer (ESCLC) - DelveInsight's Analytical Perspective

5. Therapeutic Assessment

6. Extensive-Stage Small Cell Lung Cancer (ESCLC) Late-Stage Products (Phase-III)

7. Extensive-Stage Small Cell Lung Cancer (ESCLC) Mid-Stage Products (Phase-II)

8. Early Stage Products (Phase-I)

9. Pre-clinical Products and Discovery Stage Products

10. Inactive Products

11. Dormant Products

12. Extensive-Stage Small Cell Lung Cancer (ESCLC) Discontinued Products

13. Extensive-Stage Small Cell Lung Cancer (ESCLC) Product Profiles

14. Extensive-Stage Small Cell Lung Cancer (ESCLC) Key Companies

15. Extensive-Stage Small Cell Lung Cancer (ESCLC) Key Products

16. Dormant and Discontinued Products

17. Extensive-Stage Small Cell Lung Cancer (ESCLC) Unmet Needs

18. Extensive-Stage Small Cell Lung Cancer (ESCLC) Future Perspectives

19. Extensive-Stage Small Cell Lung Cancer (ESCLC) Analyst Review

20. Appendix

21. Report Methodology

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About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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