Press release
NASH/MASH Treatment Market Opportunity in Obesity-Co-Morbidity Therapies and GLP 1 Combo Approaches
NASH/MASH Treatment Market
As per our analysis, the NASH/MASH Treatment Market is spearheaded by Madrigal Pharmaceuticals (with its first-in-class drug resmetirom/Rezdiffra). Emerging biotech contenders include Novo Nordisk, Boehringer Ingelheim, 89bio, Inventiva, Chia Tai Tianqing, Sagimet Biosciences, and Akero Therapeutics, focusing on advanced small molecules, RNAi agents, PPAR agonists, and liver fibrosis inhibitors. Together, they foster a dynamic market with strong R&D innovation and regulatory breakthroughs.
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NASH/MASH Treatment Market M&A & Strategic Collaborations
• Madrigal secures U.S. patent for Rezdiffra until 2044, strengthening its market exclusivity in NASH/MASH therapy.
• Inventiva's Lanifibranor maintains Phase III momentum under Breakthrough status, supported by recent pipeline reports.
• Madrigal completes patient enrollment in cirrhosis trial (Phase III), advancing its MASH indication.
These highlights demonstrate a surge in patent fortification, Phase III data progression, and clinical expansion in the NASH/MASH market rather than traditional M&A.
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Key Growth Drivers & Emerging Opportunities in the NASH/MASH Treatment Market
• Rezdiffra enjoys blockbuster launch, with Q1 2025 sales of USD 137.3 million and over 17,000 patients treated.
• Strong pipeline advancement: Pan-PPAR agonist lanifibranor (Breakthrough/FTD in Phase III) and RNAi/ASO candidates (ARO-HSD, AZD2693) progress.
• Rising NASH prevalence, linked to obesity and diabetes, supports robust therapeutic demand.
• Biotech-biologic partnerships accelerate commercialization of next-gen targets (e.g., fibrosis, metabolic endpoints, GLP-1 combos).
• Strategic patent positioning and EU conditional approvals expand addressable patient populations globally.
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Regional Market Drivers in the NASH/MASH Treatment Market
North America leads, propelled by Rezdiffra's FDA approval, widespread NASH screening, and payer adoption.
Europe builds groundwork via EMA conditional authorization of Resmetirom and late-stage trial entries.
Asia-Pacific emerges with RNAi therapies, biosimilars, and obesity-linked disease management fueling pipeline interest.
LATAM & MEA show expansion due to rising metabolic disorder prevalence and increasing trial participation in emerging disease areas.
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