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Growth Of The Biopharmaceutical Sector Driving Demand For In DNA And RNA Synthesis: Key Factor Driving The Growth In The Phosphoramidite Market
The Phosphoramidite Market Report by The Business Research Company delivers a detailed market assessment, covering size projections from 2025 to 2034. This report explores crucial market trends, major drivers and market segmentation by [key segment categories].What Is the Expected Phosphoramidite Market Size During the Forecast Period?
The size of the phosphoramidite market has experienced robust growth over the past few years. The market is projected to expand from $1.01 billion in 2024 to $1.09 billion in 2025, with a compound annual growth rate (CAGR) of 7.7%. The growth in the past years was driven by several factors such as the upsurge in demand for DNA and RNA synthesis, increased usage of mRNA-based therapeutics, a rise in the occurrence of genetic disorders, amplified demand for synthetic biology, and heightened investments in genomic research.
The market for phosphoramidites is envisaged to undergo robust expansion in the forthcoming years, with a projected value of $1.44 billion by 2029, marking a compound annual growth rate (CAGR) of 7.4%. This upward trajectory in the projected period is attributable to several factors, including the escalating use of phosphoramidites, surging need for bespoke DNA and RNA synthesis, increasing demand for superior quality phosphoramidites, a refined focus on personalized medicine, and growth of biopharmaceutical companies. Key trends for the forecast period encompass the proliferation of synthetic biology, evolution of innovative phosphoramidite chemistries, strides in genomic technologies, development strides in biotechnology, and the emergence of personalized medicine.
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What Are the High-Growth Segments in the Phosphoramidite Market?
The phosphoramidite market covered in this report is segmented -
1) By Type: Deoxyribonucleic Acid (DNA) Phosphoramidites, Ribonucleic Acid (RNA) Phosphoramidites, Labeled Phosphoramidites, Modifier Phosphoramidites, Other Types
2) By Synthesis Method: H-Phosphonate Method, Phosphoramidite Method, Trivalent Phosphorus Compounds Method
3) By Application: Gene Synthesis, Deoxyribonucleic Acid (DNA) Sequencing, Deoxyribonucleic Acid (DNA) Amplification
4) By End-User: Academic Research, Pharmaceutical Industry, Biotechnology Industry
Subsegments:
1) By Deoxyribonucleic Acid (DNA) Phosphoramidites: Standard DNA Phosphoramidites, Degenerate DNA Phosphoramidites, Methylated DNA Phosphoramidites, Backbone-Modified DNA Phosphoramidites
2) By Ribonucleic Acid (RNA) Phosphoramidites: Standard RNA Phosphoramidites, 2'-O-Methyl RNA Phosphoramidites, 2'-Fluoro RNA Phosphoramidites, 2'-O-TBDMS Protected RNA Phosphoramidites
3) By Labeled Phosphoramidites: Fluorescent-Labeled Phosphoramidites, Biotin-Labeled Phosphoramidites, Digoxigenin-Labeled Phosphoramidites, Radioisotope-Labeled Phosphoramidites
4) By Modifier Phosphoramidites: Amine-Modified Phosphoramidites, Thiol-Modified Phosphoramidites, Spacer Phosphoramidites, Azide-Modified Phosphoramidites
5) By Other Types: Chimeric Phosphoramidites, Phosphorothioate Phosphoramidites, PEGylated Phosphoramidites, Photo-Cleavable Phosphoramidites
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What Key Drivers Are Expected to Influence Future Phosphoramidite Market Growth?
The phosphoramidite market's growth is likely to be propelled by the burgeoning biopharmaceutical industry. The latter encompasses various activities involved in producing biologically derived medical products like vaccines, gene therapies, monoclonal antibodies, and recombinant proteins; from research and development to production and commercialization. Its expansion can be linked to biotechnology advancements, the surging prevalence of chronic diseases, and escalated research and development investments. The introduction of biotechnology-based innovations, including gene editing and monoclonal antibody therapies, has led to the birth of highly effective and focused treatments. As phosphoramidites are indispensable for the synthesis of DNA and RNA required for gene therapies, mRNA vaccines, and oligonucleotide-based drugs, the growth of the biopharmaceutical sector supports phosphoramidite demand. With the increasing adoption of these therapies, a rise in the usage of phosphoramidites for the production of synthetic nucleic acids is anticipated, augmenting their utility in biopharmaceutical research and production. To illustrate this, the UK government reveals that in 2022 alone, the core biopharmaceutical sector generated a massive £46.7 ($58.4 billion) billion, accounting for 43% of the life sciences industry's total revenue. In addition to supporting over 126,000 jobs, this sector also witnessed a considerable increase in research and development investments. Thus, the phosphoramidite market's growth is propelled by the progressive expansion of the biopharmaceutical sector.
Which Companies Hold the Largest Share Across Different Phosphoramidite Market Segments?
Major companies operating in the phosphoramidite market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Aragen Life Sciences, Twist Bioscience, Innovassynth Technologies (I) Ltd., Tokyo Chemical Industry Co. Ltd. (TCI), Aurigene Services, Eurofins Genomics, LGC Biosearch Technologies, Link Technologies Ltd., Creative Biolabs, Biosynth Carbosynth, TriLink BioTechnologies, ChemGenes Corporation, Berry & Associates Inc., Lumiprobe Corporation, Hongene Biotech Corporation, Carbolink India Pvt. Ltd., PolyOrg Inc., Glen Research, Gene Link Inc., emp BIOTECH GmbH
What Trends Are Driving Growth in The Phosphoramidite Market?
Key players in the phosphoramidite market are striving towards innovation in DNA synthesis services to improve precision, efficiency, and environmental sustainability and decrease the production of hazardous waste in the process of DNA manufacturing. The technology of DNA synthesis involves the usage of enzymes for creating DNA sequences rather than using chemical agents, resulting in superior accuracy, speed, and sustainability. For example, in April 2022, Ansa Biotechnologies Inc., an American biotech firm, publicized the completion of an oversubscribed funding round for Series A, amounting to $68 million, led by Northpond Ventures with participation from several new and existing investors. The goal of this funding is to speed up Ansa's development of the upcoming enzymatic DNA synthesis technology, alternatively known as phosphoramidite synthesis, broaden its research and development and manufacturing infrastructure, and begin a personalized DNA synthesis service. The firm, an offshoot of the University of California, Berkeley, leverages a patented technique that allows quick and accurate synthesis of extended DNA sequences, tackling existing hurdles in the sector.
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What Are the Emerging Geographies for The Phosphoramidite Market Growth?
North America was the largest region in the phosphoramidite market in 2024. Europe is expected to be the fastest-growing region during the forecast period. The regions covered in the phosphoramidite market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
Frequently Asked Questions:
1. What Is the Market Size and Growth Rate of the Phosphoramidite Market?
2. What is the CAGR expected in the Phosphoramidite Market?
3. What Are the Key Innovations Transforming the Phosphoramidite Industry?
4. Which Region Is Leading the Phosphoramidite Market?
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