Press release
Phosphoramidite Market to Reach USD 2.38 Billion by 2030
Phosphoramidite
Phosphoramidites are essential building blocks used for the chemical synthesis of DNA and RNA oligonucleotides-fundamental components in PCR primers, molecular diagnostics, ASOs, siRNA, CRISPR guides, aptamers, mRNA production, and next-generation sequencing (NGS) workflows.
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Key Takeaways
• Market Size 2023: USD 1.38 billion
• Market Size 2030: USD 2.38 billion
• CAGR (2024-2030): 7.9%
• Largest End-Use Industry: Pharmaceutical & biotechnology companies
• Fastest Growing Use Case: mRNA vaccine and RNA therapeutic production
Market Story
Phosphoramidites are critical for synthesizing nucleic acids used across biotechnology and life sciences. Their demand is rising sharply due to expansion in:
• mRNA vaccines & novel RNA therapeutics
• CRISPR guide RNA (gRNA) development
• Oligonucleotide-based drug discovery
• Liquid biopsy, PCR, qPCR, NGS
• Genetic testing & molecular diagnostics
• Aptamer and antisense oligo development
Moreover, the success of mRNA vaccines and the rapid development of RNA-based therapies have placed phosphoramidites at the core of next-generation drug manufacturing.
As personalized medicine and genomic medicine grow, high-purity and modified phosphoramidites for specialized oligo synthesis are becoming even more essential.
Market Segments
By Product Type
• DNA Phosphoramidites (Largest Segment)
- Standard nucleoside phosphoramidites
- Modified bases
• RNA Phosphoramidites
- 2'-O-methyl
- 2'-O-TBDMS
- Specialty RNA monomers
• Modified Phosphoramidites (Fastest Growing)
- Fluorescent labels
- Linkers
- Functionalized groups
• Specialty & Custom Phosphoramidites
Modified and specialty variants drive demand in therapeutics and diagnostics.
By Application
• Oligonucleotide Synthesis (Largest Application)
• PCR & qPCR Primer Manufacturing
• NGS Library Prep
• mRNA & RNA Therapeutic Production
• Gene Editing (CRISPR gRNA)
• Antisense & siRNA Drug Development
• Aptamer Production
• Molecular Diagnostics
Oligonucleotide-based therapeutics remain the highest-impact application area.
By End User
• Pharmaceutical & Biotechnology Companies (Largest Segment)
• CDMOs & CROs
• Academic & Research Institutions
• Genetic Testing Laboratories
• Diagnostic Companies
CDMOs are expanding phosphoramidite consumption due to outsourced oligo manufacturing.
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Recent Industry Developments
• 2024 - Merck KGaA (MilliporeSigma) expanded its high-purity phosphoramidite portfolio for GMP oligonucleotide APIs.
• 2023 - Thermo Fisher Scientific increased manufacturing capacity for modified DNA/RNA phosphoramidites.
• 2023 - Bachem & Agilent strengthened oligonucleotide synthesis capabilities for RNA therapeutics.
• 2023 - LGC Biosearch Technologies expanded custom phosphoramidite offerings for qPCR and diagnostics.
• 2023 - Twist Bioscience advanced large-scale synthetic DNA/RNA manufacturing infrastructure.
Expert Quote
"Phosphoramidites are the backbone of modern genetic engineering. From mRNA vaccines to CRISPR guide synthesis, they enable nearly every breakthrough happening in molecular biology today."
- Irfan Tamboli, Business Development Executive, Exactitude Consultancy
Key Market Drivers
1. Surging Demand for mRNA Vaccines & RNA Therapeutics
Phosphoramidites enable high-throughput synthesis of RNA strands used in cutting-edge therapeutics.
2. Growth of CRISPR-Based Gene Editing
CRISPR guide RNAs require precise, high-purity phosphoramidites.
3. Increasing Adoption of Genetic Testing & NGS
PCR, qPCR, and sequencing workflows rely heavily on synthetic DNA/RNA primers.
4. Rise of Oligonucleotide Therapeutics
ASOs, siRNA, and aptamer-based drugs are expanding rapidly.
5. Advances in Synthetic Biology
Engineered organisms require custom DNA sequences constructed using specialty phosphoramidites.
Forecast Outlook (2024-2030)
Future market expansion will be driven by:
• Fully automated high-throughput oligo synthesis platforms
• AI-assisted nucleic acid design
• GMP-compliant RNA manufacturing facilities
• Expanding therapeutic pipeline for ASOs & siRNA
• Continued adoption of liquid biopsy and precision diagnostics
By 2030, high-purity, modified phosphoramidites will dominate R&D and commercial oligo manufacturing.
Regional Insights
North America
Largest market supported by strong biotech, gene therapy, and diagnostics industries.
Europe
Significant adoption in oligo therapeutics and molecular diagnostics.
Asia-Pacific
Fastest-growing region (CAGR > 9%) with RNA vaccine production expansion in China, India, and Japan.
Latin America & Middle East
Emerging opportunities driven by rising genetic testing demand.
Conclusion
The Phosphoramidite Market is positioned for steady growth as DNA/RNA synthesis, mRNA therapeutics, and gene-editing applications expand globally. With rapid advancements in oligo drug development, phosphoramidites will remain essential building blocks for next-generation biotechnology.
This report is also available in the following languages : Japanese (ホスホラミダイト市場), Korean (포스포라미다이트 시장), Chinese (亚磷酰胺市场), French (Marché du phosphoramidite), German (Phosphoramidit-Markt), and Italian (Mercato della fosforamidite), etc.
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About Us
Exactitude Consultancy is a market research & consulting services firm which helps its client to address their most pressing strategic and business challenges. Our market research helps clients to address critical business challenges and also helps make optimized business decisions with our fact-based research insights, market intelligence, and accurate data.
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https://exactitudeconsultancy.com/
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PHONE NUMBER +1 (704) 266-3234
EMAIL ADDRESS: sales@exactitudeconsultancy.com
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