Iron Deficiency Drives The Growth Of The Market Driver: Leading Transformation in the Restless Leg Syndrome Market in 2025

What combination of drivers is leading to accelerated growth in the restless leg syndrome market?
The growing prevalence of iron deficiency is anticipated to accelerate the growth of the restless leg syndrome market in the coming years. Iron deficiency occurs when the body lacks sufficient iron to produce an adequate number of healthy red blood cells, leading to symptoms like fatigue, weakness, and pale skin. The rise in iron deficiency is driven by factors such as inadequate dietary intake, blood loss, malabsorption conditions, and higher iron requirements during pregnancy or growth. Treatment for restless leg syndrome often includes iron supplementation or dietary changes, which help to alleviate discomfort while also addressing the underlying iron deficiency, promoting red blood cell production, and improving neurological function. For instance, in January 2025, according to the National Health Service England, during the 2023-24 period, 191,927 hospital admissions were recorded due to iron deficiency, showing an 11% increase from the previous year. Thus, the growing prevalence of iron deficiency is propelling the growth of the restless leg syndrome market.

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What is the projected compound annual growth rate (CAGR) of the restless leg syndrome market from 2025 to 2034, and what factors influence it?
The restless leg syndrome market has seen strong growth, increasing from $1.91 billion in 2024 to $2.17 billion in 2025 at a CAGR of 13.8%. Growth drivers include increasing alcohol consumption rates, higher health insurance coverage, greater availability of over-the-counter medications, expanding public health initiatives, and a rising incidence of mental health issues.

The restless leg syndrome market is anticipated to grow rapidly, reaching $3.59 billion by 2029 at a CAGR of 13.4%. The expansion is driven by increased healthcare investments, educational and awareness initiatives, higher rates of early diagnosis, increased government funding, and greater participation in clinical trials. Notable trends include AI-powered personalized treatment strategies, next-generation neurostimulation devices, deep learning algorithms for diagnosis, brainwave modulation technologies, and wearable exoskeletons for leg movement assistance.

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How are the latest trends influencing the growth of the restless leg syndrome market?
Leading companies in the restless leg syndrome (RLS) market are working on innovative solutions such as novel non-invasive therapies to improve symptom management and enhance patient outcomes. Novel non-invasive therapies involve advanced techniques like electrical stimulation, light therapy, or external devices to relieve symptoms without surgery or skin penetration. For instance, in April 2023, Varco Leg Care, an India-based consumer health technology company, received FDA De Novo approval for its NTX100 Tonic Motor Activation (TOMAC) System. This system is designed to treat moderate to severe RLS symptoms and improve sleep quality in patients who do not respond to medications. The device works by electrically activating the peroneal nerves on both sides of the body, producing sustained muscle activation that helps alleviate RLS symptoms while being compatible with sleep.

What are the major segments of the restless leg syndrome market and their role in driving growth?
The restless leg syndrome market covered in this report is segmented -

1) By Type: Primary Restless Legs Syndrome, Secondary Restless Legs Syndrome
2) By Treatment Type: Medicine And Devices, Surgery
3) By Route Of Administration: Oral, Injectable
4) By Distribution Channel: Hospital Pharmacy, Retail Pharmacy, Online Pharmacy
5) By Application: Neurological Treatment, Sleep Disorders, Movement Disorders, Symptom Management

Subsegments:
1) By Primary Restless Legs Syndrome: Idiopathic Restless Legs Syndrome, Hereditary Restless Legs Syndrome
2) By Secondary Restless Legs Syndrome: Iron Deficiency-related Restless Legs Syndrome, Chronic Kidney Disease-related Restless Legs Syndrome, Pregnancy-related Restless Legs Syndrome, Medication-induced Restless Legs Syndrome

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Which regions are key players in the growth of the restless leg syndrome market?
Europe was the largest region in the restless leg syndrome market in 2024. North-America is expected to be the fastest-growing region in the forecast period. The regions covered in the restless leg syndrome market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

Who are the key firms paving the way for growth in the restless leg syndrome market?
Major companies operating in the restless leg syndrome market are Pfizer Inc., Roche Holding AG, Merck & Co Inc., Novartis International AG, GlaxoSmithKline plc, Teva Pharmaceutical Industries Ltd., Boehringer Ingelheim International GmbH, Baxter International Inc., Astellas Pharma Inc., UCB S.A., Kyowa Kirin Co Ltd., Amneal Pharmaceuticals Inc., Lupin Pharmaceuticals Inc., Alembic Pharmaceuticals Limited, Mundipharma International Limited, Azurity Pharmaceuticals LLC, Otsuka Pharmaceutical Co Ltd., Horizon Therapeutics plc, Mylan N.V., Apollo Pharmacy Limited

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What Is Covered In The Restless Leg Syndrome Global Market Report?

•Market Size Forecast: Examine the restless leg syndrome market size across key regions, countries, product categories, and applications.
•Segmentation Insights: Identify and classify subsegments within the restless leg syndrome market for a structured understanding.
•Key Players Overview: Analyze major players in the restless leg syndrome market, including their market value, share, and competitive positioning.
•Growth Trends Exploration: Assess individual growth patterns and future opportunities in the restless leg syndrome market.
•Segment Contributions: Evaluate how different segments drive overall growth in the restless leg syndrome market.
•Growth Factors: Highlight key drivers and opportunities influencing the expansion of the restless leg syndrome market.
•Industry Challenges: Identify potential risks and obstacles affecting the restless leg syndrome market.
•Competitive Landscape: Review strategic developments in the restless leg syndrome market, including expansions, agreements, and new product launches.

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