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Key Trend Reshaping the Histone Deacetylase (HDAC) Inhibitors Market in 2025: Shuttle Pharmaceuticals Advances Cancer Treatment With New HDAC Inhibitor Patents
Histone Deacetylase (HDAC) Inhibitors Market Share
The increasing incidence of neurodegenerative diseases is expected to drive the growth of the histone deacetylase (HDAC) inhibitors market. Neurodegenerative disorders, such as Alzheimer's disease, involve the progressive degeneration of neurons, leading to cognitive and motor dysfunction. The rising prevalence of these disorders is due to aging, genetics, and environmental factors. HDAC inhibitors are being researched as potential treatments for neurodegenerative diseases because they can modulate gene expression and protect neurons. For example, the Centers for Disease Control and Prevention (CDC) projected that by 2060, nearly 14 million older adults in the U.S. would be living with Alzheimer's disease, up from 6.7 million in 2024. As such, the rising incidence of neurodegenerative disorders is propelling the HDAC inhibitors market.
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What is the future CAGR of the histone deacetylase (hdac) inhibitors market, and how will it impact industry expansion?
The histone deacetylase (HDAC) inhibitors market has expanded significantly, projected to grow from $1.23 billion in 2024 to $1.33 billion in 2025 at a CAGR of 7.9%. Growth factors include increased funding for epigenetic research, the rising prevalence of drug-resistant cancers, greater healthcare expenditure, growing utilization of HDAC inhibitors in veterinary medicine, and increasing investment in bioinformatics.
The histone deacetylase (HDAC) inhibitors market is set to grow strongly, reaching $1.77 billion by 2029 with a CAGR of 7.5%. Growth drivers include a rising incidence of neurodegenerative disorders, increasing cancer awareness, growing investment in drug development, and expanding clinical trials. Major trends include personalized medicine adoption, cancer immunotherapy advancements, digital health integration, bioinformatics applications, and technological innovations.
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What are the most significant trends transforming the histone deacetylase (hdac) inhibitors market today?
In the histone deacetylase (HDAC) inhibitors market, companies are working on innovative HDAC inhibitors for cancer therapy to improve efficacy and reduce side effects. HDAC inhibitors work by inhibiting HDAC enzymes, which impact gene expression. In September 2023, Shuttle Pharmaceuticals Holdings Inc. was awarded patents for new HDAC inhibitors designed to target enzymes involved in cancer progression. These inhibitors offer greater potency and selectivity, minimizing side effects while improving safety profiles for cancer patients.
Which key market segments comprise the histone deacetylase (hdac) inhibitors market and drive its revenue growth?
The histone deacetylase (HDAC) inhibitors market covered in this report is segmented -
1) By Class: Class I HDACs, Class II HDACs, Class III HDACs, Class IV HDACs
2) By Route Of Administration: Oral HDAC Inhibitors, Parenteral HDAC Inhibitors
3) By Application: Oncology, Neurology, Other Applications
4) By End User: Hospitals, Academic And Research Institutes, Pharmaceutical Companies, Other End Users
Subsegments
1) By Class I HDACs: HDAC1, HDAC2, HDAC3, HDAC8
2) By Class II HDACs: HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, HDAC10
3) By Class III HDACs (Sirtuins): SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
4) By Class IV HDACs: HDAC11
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What regions are at the forefront of histone deacetylase (hdac) inhibitors market expansion?
North America was the largest region in the histone deacetylase (HDAC) inhibitors market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the histone deacetylase (HDAC) inhibitors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
Who are the leading players fueling growth in the histone deacetylase (hdac) inhibitors market?
Major companies operating in the histone deacetylase (HDAC) inhibitors market are Bristol-Myers Squibb Company, Novartis AG, Merck KGaA, Abcam plc, Pharmacyclics LLC, R&D Systems Inc., Tenaya Therapeutics Inc., Syndax Pharmaceuticals Inc., Italfarmaco SpA, InvivoGen Corporation, TCI Chemicals (India) Pvt. Ltd., 4SC AG, Medivir AB, Mirati Therapeutics Inc., Spectrum Pharmaceuticals Inc., Curis Inc., Acetylon Pharmaceuticals Inc., Oryzon Genomics SA, Xynomic Pharmaceuticals Inc., Celleron Therapeutics Ltd., Midatech Pharma PLC, Karus Therapeutics Ltd., Shenzhen Chipscreen Biosciences Co. Ltd.
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What Is Covered In The Histone Deacetylase (HDAC) Inhibitors Global Market Report?
•Market Size Forecast: Examine the histone deacetylase (hdac) inhibitors market size across key regions, countries, product categories, and applications.
•Segmentation Insights: Identify and classify subsegments within the histone deacetylase (hdac) inhibitors market for a structured understanding.
•Key Players Overview: Analyze major players in the histone deacetylase (hdac) inhibitors market, including their market value, share, and competitive positioning.
•Growth Trends Exploration: Assess individual growth patterns and future opportunities in the histone deacetylase (hdac) inhibitors market.
•Segment Contributions: Evaluate how different segments drive overall growth in the histone deacetylase (hdac) inhibitors market.
•Growth Factors: Highlight key drivers and opportunities influencing the expansion of the histone deacetylase (hdac) inhibitors market.
•Industry Challenges: Identify potential risks and obstacles affecting the histone deacetylase (hdac) inhibitors market.
•Competitive Landscape: Review strategic developments in the histone deacetylase (hdac) inhibitors market, including expansions, agreements, and new product launches.
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Overview
HDAC inhibitors are a kind of anti-cancer drug that works by causing cell cycle arrest, apoptosis, and death in cancer cells through non-epigenetic or epigenetic control. HDAC inhibitors (HDACi) are potential medicines that have already demonstrated promise in oncological applications such as cancer detection, treatment, and prognostic. Vorinostat (Merck & Co. Inc.) is a new medication that is used to treat epidermal T cell lymphoma as it progresses, relapses, or…
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