HDAC Inhibitors Market - Increasing R&D activities for cancer is expected to boost HDAC inhibitors market during the forecast period

Overview

HDAC inhibitors are a kind of anti-cancer drug that works by causing cell cycle arrest, apoptosis, and death in cancer cells through non-epigenetic or epigenetic control. HDAC inhibitors (HDACi) are potential medicines that have already demonstrated promise in oncological applications such as cancer detection, treatment, and prognostic. Vorinostat (Merck & Co. Inc.) is a new medication that is used to treat epidermal T cell lymphoma as it progresses, relapses, or while being treated. Current candidates have shown promise in pre-clinical and clinical studies for a variety of illnesses, including neurological disorders, heart problems, and HIV infections.

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Drivers

The demand for HDAC inhibitors is expected to increase in the near future due to an increasing number of applications in different therapeutic areas such as neurodegenerative diseases such as Huntington's and Alzheimer's disease, Polycythemia vera, inflammation, and essential Thrombocythemia, Myelofibrosis.

Growing cancer-related R&D is projected to drive the global HDAC inhibitors market in the coming years. Novartis obtained FDA clearance in February 2015 for Farydak capsules in combination with dexamethasone and bortezomib* for patients with multiple myeloma who had previously undergone at least two regimens. The FDA's authorization of a few HDAC inhibitors for cancer therapy has sparked interest in developing novel anti-cancer medicines. Furthermore, one of the primary drivers of the global HDAC inhibitors market is increased R&D efforts for the treatment of cancer and other neurological illnesses. Around 350 clinical studies utilizing HDACi as a solo therapy or in combination with other targeted medicines against various human illnesses have been completed or are in the works.

Restraints

Doubts concerning HDAC inhibitors' therapeutic potential and strict reimbursement rules are anticipated to stifle the global HDAC inhibitors market growth in the foreseeable future. Obtaining compensation and coverage for newly authorized medications by the FDA or other international regulatory agencies might take a long time.

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Regional Analysis

Due to the increased prevalence of cancer and demand for cancer treatments in the area, North America is projected to retain a prominent position in the global HDAC inhibitors market. According to the American Cancer Society, the United States will see 1,688,780 new cancer cases and 600,920 cancer-related deaths in 2017. Better financing for cancer research and development, as well as an increasing need for effective treatments with reduced costs. Congress passed the 21st Century Cures Act in 2017, authorizing $1.8 billion in funding for the Cancer Moonshot program over a seven-year period. Due to the rising presence of well-established healthcare infrastructure, early acceptance of novel medicines, and growing R&D expenditure capacity, Europe is anticipated to see remarkable growth over the forecast period (2017–2025).

Competitive Landscape

Key companies contributing in the global HDAC inhibitors market are Chipscreen, GSK, Novartis, Celldex, AbbVie, Spectrum Pharmaceuticals, Celgene, Syndax, Onxeo, Merck, and Chroma Therapeutics.

Various pharmaceutical firms are increasingly investing in R&D and preclinical activities of HDACi for different applications. In January 2018, Syndax and Genentech extended their study of the effects of combining PD-L1 and HDAC inhibitors. This new contract permits Genentech to test its Tecentriq with Syndax’s entinostat in a subset of breast cancer patients.

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