Key Trend Reshaping the In Situ Hybridization Market in 2025: Innovative RNA Detection Assays Drive Advances In Gene Therapy And Research Applications

What combination of drivers is leading to accelerated growth in the in situ hybridization market?
The upsurge in infectious diseases is anticipated to fuel the expansion of the in-situ hybridization market. These diseases, which can be transmitted between individuals through contaminated food and drink or via pathogens like viruses, bacteria, fungi, and parasites, are characterized by in-situ hybridization (ISH) using specific labeled nucleic acid sequences (probes) to detect corresponding nucleic acid sequences present in the tissue. Consequently, the rise in infectious diseases encourages the growth of the in-situ hybridization market. For example, the US-based government agency, the Centers for Disease Control and Prevention, reported that the number of tuberculosis cases increased from 8,320 in 2022 to 9,615 in 2023 in March 2024, marking an increase of 1,295 cases. Hence, the escalating infectious diseases are propelling the expansion of the in-situ hybridization market.

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What is the projected compound annual growth rate (CAGR) of the in situ hybridization market from 2025 to 2034, and what factors influence it?
The market for in situ hybridization has seen robust growth lately. Its size is set to increase from $1.68 billion in 2024 to $1.83 billion in 2025, with a compound annual growth rate (CAGR) of 8.9%. Factors that contributed to this growth during the historic period include early adoption in research, the development of molecular biology tools, advancements in diagnostic applications, a shift in the focus of biomedical research, and a rise in investment in biotechnology.

The market size for in situ hybridization is predicted to grow significantly in the coming years. The market is projected to reach "$2.79 billion by 2029 with a compound annual growth rate (CAGR) of 11.2%. The anticipated growth during the forecast period is attributed to factors such as its rising use in clinical diagnostics, an increase in research and development funding, automation, and high-throughput solutions, and broader applications in the neuroscience and pathology sectors. Key trends expected to influence the market during this period include advancements in molecular biology, increased demand in research applications, the growth of diagnostic applications, the need for personalized medicine, and augmented funding for biomedical research.

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How are the latest trends influencing the growth of the in situ hybridization market?
Leading firms in the in situ hybridization market are centered on the creation of unique solutions like RNA detection assays to facilitate progress in gene therapy research. An RNA detection assay, a molecular method, helps in identifying and measuring specific RNA molecules within a given sample, subsequently allowing for in-depth study of gene expression, viral infections, and other related biological processes. For instance, Bio-Techne Corporation, a life sciences company based in the US, introduced its RNAscope Plus smRNA-RNA detection assay in January 2023. This is a state-of-the-art in situ hybridization tool that allows simultaneous fluorescent detection of small regulatory RNAs or microRNAs (miRNAs) and three target RNAs or RNA biomarkers within the same tissue section. The assay facilitates single-cell and subcellular resolution, empowering researchers to effectively evaluate the biodistribution and functionality of novel gene therapies along with endogenous regulatory RNAs. The assay, suitable for large scale studies, can be used on the Leica Bond Rx platform or manually. By combining unique RNAscope and miRNAscope technologies, this assay considerably enhances comprehension of gene expression and cellular responses. This provides pivotal insights that aid in formulating personalized gene therapies for inherited or acquired diseases.

What are the major segments of the in situ hybridization market and their role in driving growth?
The in situ hybridization market covered in this report is segmented -

1) By Product: Analytical Instruments, Kits and Reagents, Software and Services, Other Products
2) By Technique: Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ hybridization (CISH)
3) By Probe: Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA)
4) By Application: Cancer, Cytogenetics, Developmental Biology, Infectious Diseases, Other Applications
5) By End Use: Research And Diagnostic Laboratories, Contract Research Organization (CROs), Academic Institutes, Other End Uses

Subsegments:
1) By Analytical Instruments: Fluorescence Microscopes, Imaging Systems, Hybridization Systems
2) By Kits and Reagents: Hybridization Kits, Detection Kits, Probes And Reagents
3) By Software and Services: Image Analysis Software, Data Management Software, Consulting And Support Services
4) By Other Products: Accessories, Control Samples, Maintenance Supplies

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Which regions are key players in the growth of the in situ hybridization market?
North America was the largest region in the in situ hybridization market in 2024. Asia-Pacific is expected to be the fastest-growing region in the global in situ hybridization market during the forecast period. The regions covered in the in situ hybridization market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa

Who are the key firms paving the way for growth in the in situ hybridization market?
Major companies operating in the in situ hybridization market include Thermo Fisher Scientific Inc., Bio SB Inc., BioGenex Laboratories, Advanced Cell Diagnostics Inc., Exiqon A/S, Agilent Technologies Inc., F. Hoffmann-La Roche AG, Abbott Laboratories Inc., Merck KGaA, PerkinElmer Inc., Biocare Medical LLC, Genemed Biotechnologies, Danaher Corporation, Leica Biosystems Nussloch GmbH, Bio-Rad Laboratories Inc., Oxford Gene Technology, Abnova Corporation, Qiagen, Bio-Techne Corporation, Biochain Institute Inc., Cytocell Ltd., Enzo Life Sciences Inc., Eurofins Scientific SE, FISH Technologies Sdn Bhd, Genetix Biotech Asia Pvt. Ltd., Zytomed System GmbH, Akoya Biosciences Inc., Becton Dickinson and Company (BD), DAKO Systemtechnik und Service GmbH & Co, Molecular Devices LLC., NanoString Technologies Inc., Visiopharm A/S

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What Is Covered In The In Situ Hybridization Global Market Report?

• Market Size Forecast: Examine the in situ hybridization market size across key regions, countries, product categories, and applications.
• Segmentation Insights: Identify and classify subsegments within the in situ hybridization market for a structured understanding.
• Key Players Overview: Analyze major players in the in situ hybridization market, including their market value, share, and competitive positioning.
• Growth Trends Exploration: Assess individual growth patterns and future opportunities in the in situ hybridization market.
• Segment Contributions: Evaluate how different segments drive overall growth in the in situ hybridization market.
• Growth Factors: Highlight key drivers and opportunities influencing the expansion of the in situ hybridization market.
• Industry Challenges: Identify potential risks and obstacles affecting the in situ hybridization market.
• Competitive Landscape: Review strategic developments in the in situ hybridization market, including expansions, agreements, and new product launches.

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