Press release
Berthold Technologies Redefines Precision in HPLC Detection with Cutting-Edge Radiochromatography Solutions
Berthold HPLC detector
As a global leader in bioanalytical instrumentation, Berthold's radio-HPLC detectors are transforming how laboratories across pharmaceuticals, environmental science, and nuclear medicine achieve unparalleled accuracy in separating and quantifying radiolabeled compounds.
The Critical Role of HPLC Detectors in Modern Science
Chromatography remains a cornerstone of analytical chemistry, enabling the separation of complex mixtures into individual components.
However, the true power of HPLC lies in its detection systems. Unlike universal detectors, HPLC requires specialized solutions tailored to the unique properties of analytes-whether they absorb UV light, fluoresce, or emit radioactivity.
For radioactive compounds, such as those labeled with isotopes like ¹⁴C, ³H, or ¹²⁵I, traditional detectors fall short. This is where Berthold's radio-HPLC detectors excel, offering unmatched sensitivity for applications ranging from drug metabolism studies to environmental contaminant tracking.
Berthold's Flagship Solutions: HERM LB 500 and FlowStar² LB 514
1. HERM LB 500: Flexibility Meets Precision
Designed for laboratories requiring adaptability, the HERM LB 500 supports dual detector configurations: the NaI detector for gamma and high-energy beta isotopes and the fLumo detector for PET and chemiluminescence applications. Its compact, lead-free design simplifies integration into existing HPLC systems via USB or analog outputs, making it ideal for high-background environments like nuclear medicine labs. Key features include:
• Direct positron measurement for PET isotopes, eliminating bulky shielding
• Low-noise photon counting with a head-on PMT for detecting faint chemiluminescence signals
• Compliance with GLP/GMP standards, ensuring reproducibility in quality control
2. FlowStar² LB 514: The Ultimate High-Sensitivity Platform
The FlowStar² LB 514 redefines ease of use with its intuitive touchscreen interface and SmartCell technology. Each SmartCell contains an embedded chip that auto-configures system parameters, streamlining workflows for isotopes like ⁹⁹mTc and ¹¹¹In 511. Highlights include:
• Random coincidence counting and luminescence subtraction to minimize background noise
• Integrated A/D converter for seamless data acquisition from external instruments (e.g., UV detectors)
• Dual analog outputs for compatibility with all HPLC data
systems
Applications Driving
Berthold's detectors are pivotal in addressing global challenges:
• Pharmaceutical Development: Quantifying radiolabeled drugs and metabolites with precision, accelerating FDA approvals
• Environmental Monitoring: Detecting trace contaminants like pesticides and pharmaceuticals at ultralow concentrations
• Radiopharmaceutical QC: Ensuring purity of ⁶⁸Ga-labeled antibodies and ¹⁸F-based PET tracers for cancer diagnostics
Recent studies published in EJNMMI Research and Cancer Research underscore the reliability of Berthold's systems in cutting-edge research, such as optimizing folate conjugates for tumor imaging.
Software Integration: Powering Smarter Workflows
Berthold's RadioStar software and Chromeleon™ drivers bridge hardware and digital analysis, offering:
• Real-time chromatogram displays for instant data interpretation
• Half-life correction for short-lived isotopes, critical in radiopharmacy
• Customizable reports to meet stringent regulatory requirements
Commitment to Safety and Sustainability
The FlowStar²'s waste valve technology ensures only radioactive fractions are diverted to specialized containers, reducing hazardous waste by up to 70% 11. Meanwhile, the HERM's automatic shutdown feature enhances operational safety in high-radiation environments.
For more information, visit https://www.berthold.com/ or contact our team at info@berthold.com.
Berthold Technologies GmbH & Co. KG
Calmbacher Str. 22
75323 Bad Wildbad
Phone: +49 7081 177-0
E-Mai: info[at]Berthold.com
https://www.berthold.com/
Berthold Technologies is a global technology leader in life sciences, process control, and radiation protection. Berthold delivers integrated measuring solutions that have been trusted by scientists, technicians and engineers since more than 70 years.
Berthold is a family-run business, rooted in the Black Forest (Baden-Wuerttemberg, Germany), a region famous for entrepreneurship and numerous innovations. The company was founded in 1949 by Prof. Dr. Rudolf Berthold founds the company in 1949 under the name "Laboratorium Prof. Dr. Rudolf Berthold" in Bad Wildbad, Germany.
Every day, Berthold strives to create a healthier world, a safer environment and more efficient manufacturing processes through superior products and services.
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