Primary Sclerosing Cholangitis Pipeline 2024: Clinical Trials Assessment, FDA Approvals, Therapies, and Key Companies Involved by DelveInsight | Engitix, GRI Bio, Qing Bile Therapeutics, Sirnaomics, Cascade Pharma, Chemomab Therapeutics, Mirum Pharmac, Pl

(Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Primary Sclerosing Cholangitis pipeline constitutes 14+ key companies continuously working towards developing 14+ Primary Sclerosing Cholangitis treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight.

"Primary Sclerosing Cholangitis Pipeline Insight, 2024" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Primary Sclerosing Cholangitis Market.

The Primary Sclerosing Cholangitis Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, FDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

Some of the key takeaways from the Primary Sclerosing Cholangitis Pipeline Report: https://www.delveinsight.com/sample-request/primary-sclerosing-cholangitis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr
• Companies across the globe are diligently working toward developing novel Primary Sclerosing Cholangitis treatment therapies with a considerable amount of success over the years.
• Primary Sclerosing Cholangitis companies working in the treatment market are HighTide Biopharma, Gilead Sciences, Immunic, Engitix, GRI Bio, Qing Bile Therapeutics, Sirnaomics, Cascade Pharmaceuticals, Chemomab Therapeutics, Mirum Pharmaceuticals, Pliant Therapeutics, Inc., HighTide Biopharma, Dr. Falk Pharma, Mirum Pharmaceuticals, CymaBay Therapeutics, Ipsen, Genfit, Albireo, and others, are developing therapies for the Primary Sclerosing Cholangitis treatment
• Emerging Primary Sclerosing Cholangitis therapies in the different phases of clinical trials are- HTD 1801, GS-9674, IMU-838, Research programme-antifibrotic therapeutics, GRI-0124, QBT-002, STP707, CS0159, CM 101, Volixibat, PLN-74809 (bexotegrast), HTD1801, Norursodeoxycholic acid, Volixibat, Seladelpar, Elafibranor, A3907, and others are expected to have a significant impact on the Primary Sclerosing Cholangitis market in the coming years.
• In July 2024, Chemomab Therapeutics Ltd. (Nasdaq: CMMB), a clinical-stage biotechnology company focused on developing innovative therapies for fibro-inflammatory diseases with significant unmet needs, has announced positive topline results from its Phase 2 SPRING trial evaluating its first-in-class monoclonal antibody, CM-101, in patients with primary sclerosing cholangitis (PSC). CM-101 successfully met its primary endpoint of safety and tolerability and showed anti-fibrotic, anti-inflammatory, and anti-cholestatic effects across various disease-related secondary efficacy endpoints, including a statistically significant improvement in liver stiffness, a critical marker for PSC. CM-101 is the first investigational drug developed for PSC that demonstrates broad, clinically relevant effects on all three disease components, supporting its multifactorial mechanism of action and potential for disease modification.
• In November 2023, Chemomab Therapeutics Ltd. (Nasdaq: CMMB), a clinical-stage biotech firm dedicated to pioneering treatments for fibro-inflammatory diseases with significant unmet needs, has revealed that the U.S. Food and Drug Administration (FDA) granted Fast Track designation to CM-101 for treating primary sclerosing cholangitis (PSC) in adult patients. PSC is a fibrotic liver ailment associated with risks like liver transplant, cancer, and premature mortality.
• In September 2023, Pliant Therapeutics, Inc. (Nasdaq: PLRX), has announced encouraging findings from the INTEGRIS-PSC Phase 2a clinical trial of bexotegrast in patients with primary sclerosing cholangitis (PSC) and suspected moderate to severe liver fibrosis. The trial successfully achieved its primary and secondary objectives, indicating favorable tolerance of bexotegrast over a 12-week treatment period, with its plasma levels escalating proportionally to dosage. Furthermore, the trial explored efficacy through endpoints such as alterations in liver fibrosis markers (including Enhanced Liver Fibrosis (ELF) score and PRO-C3 levels), liver biochemistry, and magnetic resonance imaging (MRI) of the liver.
• In March 2023, Pliant Therapeutics, Inc. revealed the initiation of enrollment in a Phase IIa trial of bexotegrast at a dosage of 320 mg administered once daily for a duration ranging from at least 24 weeks to up to 48 weeks. This trial focuses on patients diagnosed with primary sclerosing cholangitis (PSC) following a favorable safety review conducted by an independent Data Safety Monitoring Board (DSMB).

Primary Sclerosing Cholangitis Overview
Primary Sclerosing Cholangitis (PSC) is a chronic liver disease characterized by inflammation and scarring of the bile ducts, both inside and outside the liver.

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Emerging Primary Sclerosing Cholangitis Drugs Under Different Phases of Clinical Development Include:
• HTD 1801: HighTide Biopharma
• GS-9674: Gilead Sciences
• IMU-838: Immunic
• Research programme: antifibrotic therapeutics Engitix
• GRI-0124: GRI Bio
• QBT-002: Qing Bile Therapeutics
• STP707: Sirnaomics
• CS0159: Cascade Pharmaceuticals
• CM 101: Chemomab Therapeutics
• Volixibat: Mirum Pharmaceuticals
• PLN-74809 (bexotegrast): Pliant Therapeutics, Inc.
• HTD1801: HighTide Biopharma
• Norursodeoxycholic acid: Dr. Falk Pharma
• Volixibat: Mirum Pharmaceuticals
• Seladelpar: CymaBay Therapeutics
• Elafibranor: Ipsen/Genfit
• A3907: Albireo/IPSEN

Primary Sclerosing Cholangitis Route of Administration
Primary Sclerosing Cholangitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
• Oral
• Parenteral
• Intravitreal
• Subretinal
• Topical
• Molecule Type

Primary Sclerosing Cholangitis Molecule Type
Primary Sclerosing Cholangitis Products have been categorized under various Molecule types, such as
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy
• Product Type

Primary Sclerosing Cholangitis Pipeline Therapeutics Assessment
• Primary Sclerosing Cholangitis Assessment by Product Type
• Primary Sclerosing Cholangitis By Stage and Product Type
• Primary Sclerosing Cholangitis Assessment by Route of Administration
• Primary Sclerosing Cholangitis By Stage and Route of Administration
• Primary Sclerosing Cholangitis Assessment by Molecule Type
• Primary Sclerosing Cholangitis by Stage and Molecule Type

DelveInsight's Primary Sclerosing Cholangitis Report covers around 14+ products under different phases of clinical development like
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Further Primary Sclerosing Cholangitis product details are provided in the report. Download the Primary Sclerosing Cholangitis pipeline report to learn more about the emerging Primary Sclerosing Cholangitis therapies
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Some of the key companies in the Primary Sclerosing Cholangitis Therapeutics Market include:
Key companies developing therapies for Primary Sclerosing Cholangitis are - HighTide Biopharma, Dr. Falk Pharma, Mirum Pharmaceuticals, Pliant Therapeutics, Inc., Chemomab Therapeutics, CymaBay Therapeutics, Genfit, Albireo, IPSEN, and others.

Primary Sclerosing Cholangitis Pipeline Analysis:
The Primary Sclerosing Cholangitis pipeline report provides insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of Primary Sclerosing Cholangitis with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Primary Sclerosing Cholangitis Treatment.
• Primary Sclerosing Cholangitis key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Primary Sclerosing Cholangitis Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Primary Sclerosing Cholangitis market.
The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Primary Sclerosing Cholangitis drugs and therapies
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Primary Sclerosing Cholangitis Pipeline Market Drivers
• Increasing prevalence of diseases associated with PSC such as liver cancer and inflammatory bowel disease, A rising number of research studies on PSC are some of the important factors that are fueling the Primary Sclerosing Cholangitis Market.

Primary Sclerosing Cholangitis Pipeline Market Barriers
• However, withdrawal of molecules from late clinical stages, lack of skilled professionals or trained expertise and other factors are creating obstacles in the Primary Sclerosing Cholangitis Market growth.

Scope of Primary Sclerosing Cholangitis Pipeline Drug Insight
• Coverage: Global
• Key Primary Sclerosing Cholangitis Companies: HighTide Biopharma, Gilead Sciences, Immunic, Engitix, GRI Bio, Qing Bile Therapeutics, Sirnaomics, Cascade Pharmaceuticals, Chemomab Therapeutics, Mirum Pharmaceuticals, Pliant Therapeutics, Inc., HighTide Biopharma, Dr. Falk Pharma, Mirum Pharmaceuticals, CymaBay Therapeutics, Ipsen, Genfit, Albireo, and others
• Key Primary Sclerosing Cholangitis Therapies: HTD 1801, GS-9674, IMU-838, Research programme-antifibrotic therapeutics, GRI-0124, QBT-002, STP707, CS0159, CM 101, Volixibat, PLN-74809 (bexotegrast), HTD1801, Norursodeoxycholic acid, Volixibat, Seladelpar, Elafibranor, A3907, and others
• Primary Sclerosing Cholangitis Therapeutic Assessment: Primary Sclerosing Cholangitis current marketed and Primary Sclerosing Cholangitis emerging therapies
• Primary Sclerosing Cholangitis Market Dynamics: Primary Sclerosing Cholangitis market drivers and Primary Sclerosing Cholangitis market barriers

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Table of Contents
1. Primary Sclerosing Cholangitis Report Introduction
2. Primary Sclerosing Cholangitis Executive Summary
3. Primary Sclerosing Cholangitis Overview
4. Primary Sclerosing Cholangitis- Analytical Perspective In-depth Commercial Assessment
5. Primary Sclerosing Cholangitis Pipeline Therapeutics
6. Primary Sclerosing Cholangitis Late Stage Products (Phase II/III)
7. Primary Sclerosing Cholangitis Mid Stage Products (Phase II)
8. Primary Sclerosing Cholangitis Early Stage Products (Phase I)
9. Primary Sclerosing Cholangitis Preclinical Stage Products
10. Primary Sclerosing Cholangitis Therapeutics Assessment
11. Primary Sclerosing Cholangitis Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Primary Sclerosing Cholangitis Key Companies
14. Primary Sclerosing Cholangitis Key Products
15. Primary Sclerosing Cholangitis Unmet Needs
16 . Primary Sclerosing Cholangitis Market Drivers and Barriers
17. Primary Sclerosing Cholangitis Future Perspectives and Conclusion
18. Primary Sclerosing Cholangitis Analyst Views
19. Appendix
20. About DelveInsight

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