mRNA Synthesis and Manufacturing Services Market Forecast: Future Developments and Projections

InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled "Global mRNA Synthesis and Manufacturing Services Market (by Type of Industry (Therapeutics and Vaccine Developers, CDMO Organizations, Custom Synthesis/Other Service Providers), Applications (Infectious Disease Vaccines, Other Vaccines, Therapeutics and Others), Scale of Operation (Research / Preclinical, Clinical, Commercial))- Market Outlook and Industry Analysis 2031"

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According to company's newest research, the Global mRNA Synthesis and Manufacturing Services Market is worth US$ 53.27 Billion in 2021 and is predicted to reach US$ 22.63 Billion in 2030, with a promising CAGR of -3.4% between 2024 and 2031.

mRNAs are nucleic acids with a single strand that are transcribed from DNA. They are an essential component of the process by which genes are expressed. mRNA molecules must be transported to the site of clinical action in order for these molecules to fulfil their clinical role of guiding the creation of the encoded protein within cells. Because of its adaptability and versatility, messenger RNA (mRNA) is a good platform for researching and developing therapeutic and preventative vaccines against a wide variety of infectious and chronic diseases. When compared to traditional pharmaceuticals, mRNA vaccines offer a greater success rate, improved immunogenicity, and require less expensive production than other vaccines. For instance, the first two vaccines against the SARS-CoV-2 viral pathogen were based on mRNA and had been licenced for usage across a variety of worldwide locations. These vaccines were also approved for use against other viral pathogens.

As a direct consequence of this, there has been a significant rise in the requirement for mRNA manufacturing capacity. mRNA-based therapies are expected to become effective treatments for a wide range of diseases that are hard to treat, such as infectious diseases, metabolic genetic diseases, cancer, cardiovascular and cerebrovascular diseases, and others. Importantly, there is no chance that mRNA could get infected by accident or be changed by insertional mutagenesis by chance. Also, mRNA has a lot of potential for treating diseases that need protein expression and has higher therapeutic efficacy than traditional protein/peptide drugs because it is continuously translated into encoded proteins/peptides that cause long-lasting expression.

This mRNA synthesis and manufacturing services market expansion is driven by the increased incidence of rare diseases, including propionic acidemia, methylmalonic acidemia, glycogen disease, metabolic and metabolic and immunological disorders, as well as chronic diseases like cancer, heart disease, pulmonary, CKD, and others. Recent advancements in this area of the biopharmaceutical sector suggest that service providers are expanding their capacities and infrastructure to meet the demand for this innovative class of biologics that is currently present and predicted. The market for mRNA synthesis and manufacturing services is expected to grow significantly over the next few years due to the rising number of clinical trials for cancer treatments and infectious diseases. Recent industry trends include more significant investments by operational firms, expanded mergers and alliances, and increased research and development efforts. For example, in April 2021, the American mRNA therapeutic developer Arcturus Therapeutics formed a Japanese company in Chiba Prefecture as part of a joint venture with Axcelead, Inc., and they are currently constructing a production facility in Minamisoma City, which is located in Fukushima Prefecture. It is anticipated that these investments would contribute positively to the sector's expansion in the years to come.

The expansion of mRNA synthesis and manufacturing services is, however, being hampered by a dearth of manufacturing procedures that are flexible, sustainable, and efficient in terms of cost. Also, the lengthy process of approvals and long-term clinical trials will hamper the market growth in the forecasting period.

The mRNA synthesis and manufacturing services market in North America will be driven by the availability of significant financing for research, the expansion of federal programmes toward RNA-based therapeutics, and the increasing number of clinical studies.

Some of the significant market players in the mRNA synthesis and manufacturing services market are eTheRNA (Etherna Immunotherapies), Eurogentec, Aldevron, biosynthesis, Biomay, Jena Biosciences, APExBIO, TriLink BioTechnologies, CELLSCRIPT, Thermo Fisher Scientific, New England Biolabs, BioNTech (Pfizer), Translate Bio, CureVac, Moderna, Ethris (AstraZeneca), Kernal Biologics, Silence Therapeutics, In-Cell-Art, Anima Biotch, H3 Biomedicine Inc., Tiba Biotechnology, Arcturus Therapeutics, Ionis Pharmaceuticals, Inc., Stemirna Therapeutics Co., Ltd., eFFECTOR Therapeutics, Inc., Ziphius Therapeutics NV, miRagen Therapeutics, Inc., RNAimmune (Sirnaomics), Skyhawk Therapeutics, Inc, Strand Therapeutics Inc., and other Prominent Players.

Key Developments in the Market :
• In Aug 2022, A novel enzymatic mRNA capping solution for the manufacture of mRNA was introduced by New England Biolabs® under the name Faustovirus Capping Enzyme. This new enzyme boosts the capping effectiveness and scalability for mRNA manufacturing workflows, including vaccine production.
• In Jan 2022, Pfizer and BioNTech signed a new global collaboration agreement to work together on developing the first mRNA-based shingles vaccine. Both Pfizer's antigen technology and BioNTech's proprietary mRNA technology will be utilised to develop potential product candidates. It is expected that clinical trials will begin in the second half of the year 2022.
• In Oct 2021, Silence Therapeutics and Hansoh Pharma announced a collaboration to develop therapeutics utilising Silence's mRNAi GOLDTM Platform. The upfront cash payment from Hansoh is expected to be sixteen million dollars, and the possible milestone payments for Silence might be as high as one billion three hundred million dollars.

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Market Segmentation:
Global mRNA Synthesis and Manufacturing Services Market, by Type of Industry 2024-2031 (Value US$ Mn)
• Therapeutics and Vaccine Developers
• CDMO Organizations
• Custom Synthesis/Other Service Providers

Global mRNA Synthesis and Manufacturing Services Market, by Applications, 2024-2031 (Value US$ Mn)
• Infectious Disease Vaccines
• Other Vaccines
• Therapeutics and Others

Global mRNA Synthesis and Manufacturing Services Market, by Scale of Operation, 2024-2031 (Value US$ Mn)
• Research / Preclinical
• Clinical
• Commercial

Global mRNA Synthesis and Manufacturing Services Market, by Region, 2024-2031 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

North America mRNA Synthesis and Manufacturing Services Market, by Country, 2024-2031 (Value US$ Mn)
• U.S.
• Canada

Europe mRNA Synthesis and Manufacturing Services Market, by Country, 2024-2031 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe

Asia Pacific mRNA Synthesis and Manufacturing Services Market, by Country, 2024-2031 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand

Latin America mRNA Synthesis and Manufacturing Services Market, by Country, 2024-2031 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa mRNA Synthesis and Manufacturing Services Market, by Country, 2024-2031 (Value US$ Mn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa
•
Why should buy this report:
 To receive a comprehensive analysis of the prospects for the global mRNA Synthesis and Manufacturing Services Market
 To receive an industry overview and future trends of the mRNA Synthesis and Manufacturing Services Market
 To analyze mRNA Synthesis and Manufacturing Services Market drivers and challenges
 To get information on the mRNA Synthesis and Manufacturing Services Market size (Value US$ Mn) forecast to 2030
 Significant investments, mergers & acquisitions in the mRNA Synthesis and Manufacturing Services Market industry

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