mRNA Revolution: A Booming Market for Manufacturing and Synthesis Services From Bench to Bedside

Global mRNA Synthesis and Manufacturing Services Market to Record an Exponential CAGR by 2030 - Exclusive Report by InsightAce Analytic

InsightAce Analytic Pvt. Ltd. has announced the publication of a market research report titled "Global mRNA Synthesis and Manufacturing Services Market (by Type of Industry (Therapeutics and Vaccine Developers, CDMO Organizations, Custom Synthesis/Other Service Providers), Applications (Infectious Disease Vaccines, Other Vaccines, Therapeutics and Others), Scale of Operation (Research / Preclinical, Clinical, Commercial))- Market Outlook and Industry Analysis 2030"

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According to company's newest research, the Global mRNA Synthesis and Manufacturing Services Market is worth US$ 53.27 Billion in 2021 and is predicted to reach US$ 22.63 Billion in 2030, with a promising CAGR of -3.4% between 2024 and 2031.

mRNA: Revolutionizing Vaccines and Gene Therapies
Messenger RNA (mRNA) is a single-stranded molecule emerging as a powerful tool in healthcare. Produced during transcription from DNA, mRNA plays a central role in protein synthesis within cells. This unique characteristic is being harnessed to develop novel therapeutic and preventative approaches.
The Rise of mRNA Vaccines

mRNA's versatility and adaptability make it highly suitable for vaccine development. mRNA vaccines offer several advantages over traditional vaccines:
• Faster Development: mRNA vaccines can be designed and produced more quickly compared to conventional vaccines.

• Enhanced Immunogenicity: mRNA vaccines can trigger robust immune responses, potentially leading to greater efficacy.

• Lower Production Costs: Manufacturing mRNA vaccines can be more cost-effective than traditional methods.

This is exemplified by the success of the first two mRNA vaccines against the SARS-CoV-2 virus, demonstrating the real-world potential of this technology. Regulatory approvals for mRNA vaccines targeting other viruses are paving the way for broader applications.

Beyond Vaccines: The Promise of mRNA Therapeutics
The growing demand for mRNA manufacturing capacity reflects the exciting potential of mRNA therapeutics. These therapies hold promise for treating a

wide range of diseases, including:
• Cancer
• Metabolic disorders
• Cerebrovascular diseases
• Infectious diseases
• Hereditary diseases

A key advantage of mRNA therapeutics is their safety profile. Unlike some viral vector-based therapies, mRNA is unlikely to integrate into the host genome, minimizing the risk of insertional mutagenesis. Furthermore, mRNA-based therapies offer the potential for targeted protein expression, leading to potentially higher therapeutic efficacy compared to conventional treatments.

In conclusion, mRNA is revolutionizing healthcare with its transformative potential in both vaccines and therapeutics. As research continues to advance, mRNA-based therapies offer great promise for tackling a vast array of previously untreatable diseases.

protein/peptide drugs because it is continuously translated into encoded proteins/peptides that cause long-lasting expression.
This mRNA synthesis and manufacturing services market expansion is driven by the increased incidence of rare diseases, including propionic acidemia, methylmalonic acidemia, glycogen disease, , metabolic and metabolic and immunological disorders, as well as chronic diseases like cancer, heart disease, pulmonary, CKD, and others.

Recent advancements in this area of the biopharmaceutical sector suggest that service providers are expanding their capacities and infrastructure to meet the demand for this innovative class of biologics that is currently present and predicted. The market for mRNA synthesis and manufacturing services is expected to grow significantly over the next few years due to the rising number of clinical trials for cancer treatments and infectious diseases. Recent industry trends include more significant investments by operational firms, expanded mergers and alliances, and increased research and development efforts.

For example, in April 2021, the American mRNA therapeutic developer Arcturus Therapeutics formed a Japanese company in Chiba Prefecture as part of a joint venture with Axcelead, Inc., and they are currently constructing a production facility in Minamisoma City, which is located in Fukushima Prefecture. It is anticipated that these investments would contribute positively to the sector's expansion in the years to come.

The expansion of mRNA synthesis and manufacturing services is, however, being hampered by a dearth of manufacturing procedures that are flexible, sustainable, and efficient in terms of cost. Also, the lengthy process of approvals and long-term clinical trials will hamper the market growth in the forecasting period.

The mRNA synthesis and manufacturing services market in North America will be driven by the availability of significant financing for research, the expansion of federal programmes toward RNA-based therapeutics, and the increasing number of clinical studies.

Some of the significant market players in the mRNA synthesis and manufacturing services market are eTheRNA (Etherna Immunotherapies), Eurogentec, Aldevron, biosynthesis, Biomay, Jena Biosciences, APExBIO, TriLink BioTechnologies, CELLSCRIPT, Thermo Fisher Scientific, New England Biolabs, BioNTech (Pfizer), Translate Bio, CureVac, Moderna, Ethris (AstraZeneca), Kernal Biologics, Silence Therapeutics,

In-Cell-Art, Anima Biotch, H3 Biomedicine Inc., Tiba Biotechnology, Arcturus Therapeutics, Ionis Pharmaceuticals, Inc., Stemirna Therapeutics Co., Ltd., eFFECTOR Therapeutics, Inc., Ziphius Therapeutics NV, miRagen Therapeutics, Inc., RNAimmune (Sirnaomics), Skyhawk Therapeutics, Inc, Strand Therapeutics Inc., and other Prominent Players.

Key Developments in the Market :
• In Aug 2022, A novel enzymatic mRNA capping solution for the manufacture of mRNA was introduced by New England Biolabs® under the name Faustovirus Capping Enzyme. This new enzyme boosts the capping effectiveness and scalability for mRNA manufacturing workflows, including vaccine production.

• In Jan 2022, Pfizer and BioNTech signed a new global collaboration agreement to work together on developing the first mRNA-based shingles vaccine. Both Pfizer's antigen technology and BioNTech's proprietary mRNA technology will be utilised to develop potential product candidates. It is expected that clinical trials will begin in the second half of the year 2022.

• In Oct 2021, Silence Therapeutics and Hansoh Pharma announced a collaboration to develop therapeutics utilising Silence's mRNAi GOLDTM Platform. The upfront cash payment from Hansoh is expected to be sixteen million dollars, and the possible milestone payments for Silence might be as high as one billion three hundred million dollars.

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Market Segmentation:
Global mRNA Synthesis and Manufacturing Services Market, by Type of Industry 2022-2030 (Value US$ Mn)
• Therapeutics and Vaccine Developers
• CDMO Organizations
• Custom Synthesis/Other Service Providers

Global mRNA Synthesis and Manufacturing Services Market, by Applications, 2022-2030 (Value US$ Mn)
• Infectious Disease Vaccines
• Other Vaccines
• Therapeutics and Others

Global mRNA Synthesis and Manufacturing Services Market, by Scale of Operation, 2022-2030 (Value US$ Mn)
• Research / Preclinical
• Clinical
• Commercial

Global mRNA Synthesis and Manufacturing Services Market, by Region, 2022-2030 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

North America mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• U.S.
• Canada

Europe mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe

Asia Pacific mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand

Latin America mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa mRNA Synthesis and Manufacturing Services Market, by Country, 2022-2030 (Value US$ Mn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa
•

Why should buy this report:
 To receive a comprehensive analysis of the prospects for the global mRNA Synthesis and Manufacturing Services Market
 To receive an industry overview and future trends of the mRNA Synthesis and Manufacturing Services Market
 To analyze mRNA Synthesis and Manufacturing Services Market drivers and challenges
 To get information on the mRNA Synthesis and Manufacturing Services Market size (Value US$ Mn) forecast to 2030
 Significant investments, mergers & acquisitions in the mRNA Synthesis and Manufacturing Services Market industry

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