Avascular Necrosis Market Growing Worldwide by Leading Key Players, Shares, and , Regional Analysis and Forecast 2024-2031 | Solara Active Pharma Sciences Limited, Bayer AG

Market Overview:

Avascular necrosis (AN) is a disease that occurs due to interrupted blood supply to the bones, resulting in the death of bone tissues. It can affect any bone but is commonly found in the hip, knee, shoulder, ankle, and wrist bones. The main symptoms of AN include pain, swelling, tenderness, and restricted movement in the affected joints. Treatment options depend on the stage of the disease and may include medication, minimally invasive procedures, joint replacement surgeries, and therapies.

Market Dynamics:

The avascular necrosis market is expected to witness significant growth over the forecast period owing to rapidly increasing geriatric population worldwide and rising incidence of associated risk factors such as long-term steroid use and excessive alcohol consumption. According to the United Nations, the global population aged 60 years and older is expected to double from 12% to 22% between 2015 and 2050. Older individuals are vulnerable to AN due to chronic diseases, mobility issues, and increased likelihood of bone injuries from falls and fractures. Another major factor driving market revenue is the rising prevalence of osteoarthritis of the hip requiring total hip replacement surgery, which is one of the treatments for advanced AN in elderly patients. It is estimated that over 250,000 total hip replacements are performed each year in the United States alone for severe osteoarthritis resulting from untreated AN. In addition, increasing healthcare expenditure and public awareness about treatment options are expected to support market growth over the forecast period.

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List of TOP Players in Market Report are: -

◘ Teva Pharmaceutical Industries Ltd.
◘ Dr. Reddy's Laboratories Ltd.
◘ Solara Active Pharma Sciences Limited
◘ Bayer AG
◘ Rochem International Inc.
◘ Alkem labs.
◘ Dwarkesh Pharmaceuticals Private Limited.
◘ Novartis AG
◘ GSK
◘ Pfizer Inc

Market Detailed Segmentation:

By Drug Type: Nonsteroidal anti-inflammatory drugs ( Ibuprofen, Naproxen Sodium), Osteoporosis drugs, Cholesterol-lowering drugs, Blood thinners, Others
By Route of Administration: Oral, Injectable
By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies

Higher incidence of avascular necrosis due to several underlying diseases is driving the growth of the avascular necrosis market

Avascular necrosis, also known as osteonecrosis or bone infarction, is a disease that results in the death of bone tissues due to an interruption in the blood supply. It commonly affects the hips, shoulders, knees and other weight-bearing joints. The incidence of avascular necrosis is increasing over the years due to rise in certain underlying diseases and risk factors that can lead to AVN. Some of the major diseases associated with avascular necrosis include alcohol abuse, autoimmune diseases like lupus and rheumatoid arthritis, bone marrow disorders, fracture, and use of oral corticosteroids. According to statistics, alcohol abuse is one of the leading causes of avascular necrosis worldwide. A study found that patients with alcohol use disorder are 15 times more likely to develop avascular necrosis compared to the general population. With rising alcohol consumption globally, the prevalence of alcohol-induced AVN is also rising. Similarly, autoimmune diseases are becoming more common which increases the risk of developing AVN. Higher usage of oral corticosteroids for treatment of various diseases is another factor augmenting the incidence rate of AVN. All these underlying risk factors are contributing to the increasing patient volume requiring treatment for avascular necrosis, thereby driving demand in the market.

Limited treatment options act as a restrain for the avascular necrosis market growth.

While the incidence of avascular necrosis is rising, the treatment options for advanced stages of AVN remain limited. Currently, the two main treatment approaches are core decompression surgery and joint replacement surgery like total hip replacement. Both procedures have certain limitations. Core decompression is mainly indicated for early stages of AVN where there is still viable bone tissue remaining. However, its long term effectiveness is still controversial. For later stages where the bone collapse is significant, the only option is joint replacement which involves invasive surgery and has risks of postoperative complications and limited lifespan of the prosthetic implant. Other promising treatment modalities like bone marrow stem cell therapy and gene therapy are still under research with uncertain clinical applications. The absence of effective minimally invasive therapies for intermediate and advanced AVN stages act as a major challenge restricting widespread adoption and growth potential of the market. Development of new treatment modalities able to halt or reverse the disease progression even at later stages can help overcome this restraint.

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Advancements in regenerative medicine provide new opportunities for treating avascular necrosis

Rising research interest and progress in the field of regenerative medicine is opening up new opportunities for treating avascular necrosis. Regenerative therapies aim to repair and replace damaged tissues through stimulation of the body's innate healing response. Specifically for AVN, technologies like bone marrow concentrate, platelet rich plasma therapy, and adult stem cell therapy hold immense potential. Bone marrow concentrate containing mesenchymal stem cells and growth factors have shown ability to regenerate necrosed bone and improve clinical symptoms when injected locally. Similarly, injection of autologous platelet-rich plasma harvested from patient's own blood has demonstrated positive outcomes in halting disease progression by promoting angiogenesis. Many ongoing clinical studies are evaluating efficacy and safety of different cell-based therapies either alone or as an adjunct to existing treatments. With further refinements, regenerative therapies may provide effective minimally invasive solutions even for advanced AVN, without need for joint replacement. This represents a significant commercial opportunity with potential to transform management of this debilitating condition.

Increased adoption of minimally invasive procedures will drive future trends in avascular necrosis market

Going forward, the demand for minimally invasive procedures for treating avascular necrosis is expected to grow significantly. Minimally invasive techniques offer advantages over traditional open surgeries like smaller incisions, lesser post-operative pain and quicker recovery time. This makes them increasingly preferable for patients. With continuous technological innovations, more advanced minimally invasive procedures are becoming available. For instance, robot-assisted hip replacement surgeries using Navigation systems allows for smaller incisions and higher precision. Similary, percutaneous drilling and grafting procedures are gaining prominence as alternatives to traditional core decompression for early AVN. Advancements are also being made in image-guided injections of regenerative therapies to treat AVN.

Furthermore, the years considered for the study are as follows:

Historical data - 2016-2022
The base year for estimation - is 2022
Estimated Year - 2024
Forecast period** - 2024 to 2031

This Avascular Necrosis Market Research/Analysis Report Contains Answers to your following Questions:

◈What are the current global trends in the Avascular Necrosis market, and will the market experience an increase or decrease in demand in the upcoming years?

◈ What is the expected demand for various product types within the Avascular Necrosis market, and what are the emerging Market applications and trends?

◈ What are the projections for the global Avascular Necrosis Market in terms of capacity, production, production value, cost, profit, market share, supply, consumption, import, and export?

◈ How will strategic developments shape the Market trajectory in the medium to long term?

◈ What factors contribute to the final price of Avascular Necrosis , and what are the raw materials used in its manufacturing?

◈ What is the market's growth potential, particularly with the increasing adoption of Avascular Necrosis in mining?

◈ What is the current and 2022 value of the global market, and who are the leading companies in this market?

◈ What recent Market trends can be leveraged to create additional revenue streams?

◈ What entry strategies, economic impact mitigation measures, and marketing channels should be considered for the Avascular Necrosis Market?

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Summarized Extracts from TOC of Market Study

Chapter 1 Avascular Necrosis Introduction and Market Overview

1.1 Objectives of the Study

1.2 Overview of Avascular Necrosis

1.3 Scope of The Study

1.3.1 Key Market Segments

1.3.2 Players Covered

1.3.3 COVID-19's impact on the Avascular Necrosis industry

1.4 Methodology of The Study

1.5 Research Data Source

Chapter 2 Executive Summary

Chapter 3 Industry Chain Analysis

Chapter 4 Market, by Type

Chapter 5 Market, by Application

Chapter 6 Market Analysis by Regions

Chapter 7 North America Market Analysis by Countries

Chapter 8 Europe Avascular Necrosis Market Analysis by Countries

Chapter 9 Asia Pacific Avascular Necrosis Market Analysis by Countries

Chapter 10 Middle East and Africa Avascular Necrosis Market Analysis by Countries

Chapter 11 South America Avascular Necrosis Market Analysis by Countries

Chapter 12 Competitive Landscape

Chapter 13 Industry Outlook

Chapter 14 Market Forecast

Chapter 15 New Project Feasibility Analysis

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