Advanced Glycation End Products Market Size to Cross USD 2.76 billion, with a CAGR of over 5.4% during 2021 to 2031: TMR study

AGEs are formed through a process known as glycation, which occurs spontaneously when reducing sugars react with amino groups on proteins, resulting in the formation of irreversible cross-links and structural modifications. AGE accumulation occurs naturally with aging but is accelerated in conditions characterized by hyperglycemia, oxidative stress, and inflammation, such as diabetes mellitus. AGEs contribute to tissue damage, organ dysfunction, and disease progression by promoting inflammation, oxidative stress, and cross-linking of extracellular matrix proteins.

Advanced Glycation End Products market is estimated to attain a valuation of US$ 2.76 Bn by the end of 2031, states a study by Transparency Market Research (TMR). Besides, the report notes that the market is prognosticated to expand at a CAGR of 5.4% during the forecast period, 2021-2031

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The significant players operating in the global Advanced Glycation End Products market are

AbbVie, Inc. (Allergan Plc), Merck KGaA, Takeda Pharmaceutical Company Limited, Estée Lauder Companies, Shiseido Company

Key Trends and Innovations:

Diagnostic Biomarkers: Biomarkers of AGE accumulation and glycation-induced damage serve as valuable tools for assessing disease risk, monitoring disease progression, and evaluating treatment efficacy. Common biomarkers include circulating AGEs, such as pentosidine, carboxymethyllysine (CML), and methylglyoxal-derived hydroimidazolone (MG-H1), as well as AGE-modified proteins and lipids detected in tissues, bodily fluids, and skin samples.

AGE Inhibitors and Breakers: Therapeutic interventions targeting AGE formation or degradation aim to prevent AGE accumulation, disrupt existing AGE cross-links, and attenuate downstream pathological effects. AGE inhibitors, such as aminoguanidine, pyridoxamine, and benfotiamine, inhibit glycation reactions by scavenging reactive carbonyl species and blocking AGE precursor formation. AGE breakers, such as alagebrium (ALT-711) and thiazolium-based compounds, cleave existing AGE cross-links and restore tissue elasticity and function.

Lifestyle Interventions: Lifestyle modifications, including dietary changes, physical activity, and antioxidant supplementation, play a crucial role in reducing AGE burden and mitigating AGE-related complications. Diets rich in antioxidants, polyphenols, and advanced glycation end product-restricted (AGE-less) foods help mitigate oxidative stress, inflammation, and glycation-induced tissue damage, promoting healthy aging and disease prevention.

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Market Drivers:

Rising Prevalence of Age-Related Diseases: The aging population and the increasing prevalence of age-related diseases, such as diabetes, cardiovascular disease, and neurodegenerative disorders, drive demand for innovative solutions to address the underlying mechanisms of aging and AGE-related pathology. As the burden of chronic diseases continues to rise globally, so does the need for effective AGE-modulating therapies and preventive strategies.

Research Advancements: Research efforts in AGE biology, glycation chemistry, and AGE-modulating interventions fuel innovation and growth in the advanced glycation end products market. Collaboration between academia, industry, and regulatory agencies accelerates drug discovery, biomarker development, and clinical translation of AGE-targeted therapies, fostering the development of novel treatments and diagnostic tools for AGE-related diseases.

Healthcare Cost Burden: The economic burden of age-related diseases, including healthcare costs, productivity losses, and caregiver burden, underscores the importance of preventive measures and early intervention strategies to mitigate AGE-related complications and reduce healthcare expenditures. Investments in preventive healthcare, disease management, and personalized medicine approaches offer opportunities for cost savings and improved patient outcomes in the long term.

Future Outlook:

The advanced glycation end products market is poised for continued growth and innovation, driven by advances in aging research, biomarker discovery, and therapeutic development. With ongoing efforts to elucidate the role of AGEs in disease pathogenesis and aging processes, stakeholders in the advanced glycation end products market aim to develop targeted interventions, personalized treatment approaches, and preventive strategies to promote healthy aging and improve the quality of life for individuals affected by AGE-related diseases.

Market Segmentation -

Type
Non-fluorescent AGEs
Fluorescent AGEs

Application
Diabetic Complications
Cancer
Bone Diseases
Neurodegenerative Diseases
Others

End User
Hospitals
Specialty Clinics
Others

This Report lets you identify the opportunities in Advanced Glycation End Products Market by means of a region:

North America (the United States, Canada, and Mexico)
Europe (Germany, UK, France, Italy, Russia, Turkey, etc.)
Asia-Pacific (China, Japan, Korea, India, Australia, and Southeast Asia (Indonesia, Thailand, Philippines, Malaysia, and Vietnam))
South America (Brazil etc.) The Middle East and Africa (North Africa and GCC Countries)

Reasons to Buy The Advanced Glycation End Products Market Report: -

1.Regional report analysis highlighting the consumption of products/services in a region also shows the factors that influence the market in each region.

2.Reports provide opportunities and threats faced by suppliers in the Advanced Glycation End Products industry around the world.

The report shows regions and sectors with the fastest growth potential.

3.A competitive environment that includes market rankings of major companies, along with new product launches, partnerships, business expansions, and acquisitions.

4.The report provides an extensive corporate profile consisting of company overviews, company insights, product benchmarks, and SWOT analysis for key market participants.

5.This report provides the industry's current and future market outlook on the recent development, growth opportunities, drivers, challenges, and two regional constraints emerging in advanced regions.

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About Us Transparency Market Research

Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. The firm scrutinizes factors shaping the dynamics of demand in various markets. The insights and perspectives on the markets evaluate opportunities in various segments. The opportunities in the segments based on source, application, demographics, sales channel, and end-use are analysed, which will determine growth in the markets over the next decade.

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