Major Depressive Disorder Market Report 2032 | Major players: Takeda Pharmaceuticals, Forest Laboratories, Otsuka Pharmaceuticals, Janssen Research & Development, Axsome Therapeutics, AbbVie, SAGE Therapeutics, Minerva Neurosciences

DelveInsight's "Major Depressive Disorder Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Major Depressive Disorder, historical and forecasted epidemiology as well as the Major Depressive Disorder market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Major Depressive Disorder market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Major Depressive Disorder market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Major Depressive Disorder treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Major Depressive Disorder market.

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Major Depressive Disorder: An Overview
Major Depressive Disorder (MDD) is a significant mental health condition characterized by persistent feelings of sadness, hopelessness, or a loss of interest in activities that were once enjoyable. It's a common and serious medical illness that negatively impacts a person's thoughts, emotions, and daily functioning.

Key features of Major Depressive Disorder include:

Persistent Depressed Mood: Individuals with MDD often experience a pervasive feeling of sadness, emptiness, or hopelessness that persists most of the day, nearly every day.

Loss of Interest or Pleasure: A marked decrease or complete loss of interest or pleasure in most activities, including ones previously enjoyed, known as anhedonia.

Various Physical and Emotional Symptoms: These may include changes in appetite or weight, sleep disturbances (insomnia or excessive sleep), fatigue, decreased energy, difficulty concentrating, indecisiveness, feelings of worthlessness or excessive guilt, and recurrent thoughts of death or suicidal ideation.

Duration and Impact: Symptoms of MDD typically persist for at least two weeks and significantly interfere with a person's ability to function in their daily life, affecting their work, school, relationships, and overall well-being.

Diagnosing Major Depressive Disorder involves a comprehensive evaluation by a mental health professional, such as a psychiatrist or psychologist. They assess the presence and severity of symptoms, duration, and their impact on the individual's life.

Treatment for MDD often involves a combination of therapies:

Psychotherapy (Talk Therapy): Cognitive-behavioral therapy (CBT), interpersonal therapy (IPT), and other forms of therapy can help individuals learn coping strategies, understand thought patterns, and address underlying issues contributing to depression.

Medication: Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or other classes of antidepressants, may be prescribed based on symptom severity and individual response.

Lifestyle Changes: Regular exercise, a healthy diet, sufficient sleep, and stress management techniques can play a supportive role in managing symptoms.

Support Groups and Peer Support: Participating in support groups or seeking support from peers who understand the challenges of depression can provide comfort and encouragement.


Learn more about Major Depressive Disorder, treatment algorithms in different geographies, and patient journeys. Contact to receive a sample @ https://www.delveinsight.com/report-store/major-depressive-disorder-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr
Major Depressive Disorder Market

The Major Depressive Disorder market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Major Depressive Disorder market trends by analyzing the impact of current Major Depressive Disorder therapies on the market and unmet needs, and drivers, barriers, and demand for better technology.

This segment gives a thorough detail of the Major Depressive Disorder market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Major Depressive Disorder market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the Major Depressive Disorder market in 7MM is expected to witness a major change in the study period 2019-2032.

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Major Depressive Disorder Epidemiology

The Major Depressive Disorder epidemiology section provides insights into the historical and current Major Depressive Disorder patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Major Depressive Disorder market report also provides the diagnosed patient pool, trends, and assumptions.

Explore more about Major Depressive Disorder Epidemiology at: https://www.delveinsight.com/report-store/major-depressive-disorder-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Major Depressive Disorder Emerging Drugs
To meet the current demands of the patient pool and to counter the major depressive disorder unmet needs of the therapeutic market, drug developers are gradually shifting their attention toward major depressive disorder as a possible indication for new targeted therapies.

Several companies are working robustly on many new therapies, such as AXS-05 (Axsome Therapeutics), Vraylar (AbbVie), Zuranolone (SAGE Therapeutics), and LY03005 (Luye Pharma). The mid-stage pipeline is crowded, with several potential therapies with the imminent attention of big pharmaceutical companies for this market space.

AXS-05 (Axsome Therapeutics), is a novel, oral, patent-protected, investigational NMDA receptor antagonist with multimodal activity under development to treat major depressive disorder and other central nervous systems (CNS) disorders. AXS-05 utilizes a proprietary formulation and dose of dextromethorphan and bupropion and Axsome's metabolic inhibition technology to modulate the delivery of the components. The dextromethorphan component of AXS-05 is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, also known as a glutamate receptor modulator, which is a novel mechanism of action, meaning it works differently than currently approved therapies for major depressive disorder. The dextromethorphan component of AXS-05 is also a sigma-1 receptor agonist. The bupropion component of AXS-05 serves to increase the bioavailability of dextromethorphan and is a norepinephrine and dopamine reuptake inhibitor.

Vraylar (AbbVie) is an oral, once-daily atypical antipsychotic approved for the acute treatment of adult patients with manic or mixed episodes associated with bipolar I disorder, with a recommended dose range of 3-6 mg/day, and for the treatment of schizophrenia in adults, with a recommended dose range of 1.5-6 mg/day.

While the mechanism of action of Vraylar in schizophrenia and bipolar I disorder is unknown, the efficacy of VRAYLAR could be mediated through a combination of partial agonist activity at central dopamine D and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Pharmacodynamic studies with cariprazine have shown that it acts as a partial agonist with high binding affinity at dopamine D3, dopamine D2, and serotonin 5-HT1A receptors. Cariprazine demonstrated up to ~eightfold greater in vitro affinity for dopamine D3 vs. D2 receptors. Cariprazine also acts as an antagonist at serotonin 5-HT2B and 5-HT2A receptors with high and moderate binding affinity, respectively, as well as it binds to the histamine H1 receptors. Cariprazine shows lower binding affinity to the serotonin 5-HT2C and 1A- adrenergic receptors and has no appreciable affinity for cholinergic muscarinic receptors. The clinical significance of these in vitro data is unknown. The company has announced the submission of the Supplemental New Drug Application to US FDA for cariprazine (Vraylar) for the adjunctive treatment of major depressive disorder.

Major Depressive Disorder Companies
Takeda Pharmaceuticals
Forest Laboratories
Otsuka Pharmaceuticals
Janssen Research & Development
Axsome Therapeutics
AbbVie
SAGE Therapeutics
Minerva Neurosciences
Luye Pharma
Relmada Therapeutics
BioLite Inc.
VistaGen Therapeutics
Praxis Precision Medicines
Intra-Cellular Therapies
Neurocrine Biosciences
Arrivo Bioventures
Sirstei Pharmaceuticals
Alto Neuroscience
Chase Therapeutics
Neumora Therapeutics, Inc.
BlackThorn Therapeutics, Inc.
Otsuka Pharmaceutical Co., Ltd.
Fabre-Kramer Pharmaceuticals
Novartis

Major Depressive Disorder Pipeline Development Activities

The Major Depressive Disorder report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Major Depressive Disorder key players involved in developing targeted therapeutics.

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Major Depressive Disorder Therapeutics Assessment

Major key companies are working proactively in the Major Depressive Disorder Therapeutics market to develop novel therapies which will drive the Major Depressive Disorder treatment markets in the upcoming years.

Learn more about the emerging therapies & key companies at: https://www.delveinsight.com/report-store/major-depressive-disorder-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Major Depressive Disorder Report Key Insights

1. Major Depressive Disorder Patient Population
2. Major Depressive Disorder Market Size and Trends
3. Key Cross Competition in the Major Depressive Disorder Market
4. Major Depressive Disorder Market Dynamics (Key Drivers and Barriers)
5. Major Depressive Disorder Market Opportunities
6. Major Depressive Disorder Therapeutic Approaches
7. Major Depressive Disorder Pipeline Analysis
8. Major Depressive Disorder Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Major Depressive Disorder Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Major Depressive Disorder Competitive Intelligence Analysis
4. Major Depressive Disorder Market Overview at a Glance
5. Major Depressive Disorder Disease Background and Overview
6. Major Depressive Disorder Patient Journey
7. Major Depressive Disorder Epidemiology and Patient Population
8. Major Depressive Disorder Treatment Algorithm, Current Treatment, and Medical Practices
9. Major Depressive Disorder Unmet Needs
10. Key Endpoints of Major Depressive Disorder Treatment
11. Major Depressive Disorder Marketed Products
12. Major Depressive Disorder Emerging Therapies
13. Major Depressive Disorder Seven Major Market Analysis
14. Attribute Analysis
15. Major Depressive Disorder Market Outlook (7 major markets)
16. Major Depressive Disorder Access and Reimbursement Overview
17. KOL Views on the Major Depressive Disorder Market
18. Major Depressive Disorder Market Drivers
19. Major Depressive Disorder Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

Get the Detailed TOC of the Major Depressive Disorder Market report here: https://www.delveinsight.com/report-store/major-depressive-disorder-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

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