Autoimmune diseases: Autoantibodies differ in their diagnostic sensitivity and specificity
Conrad, Schößler, Hiepe, Fritzler: Autoantibodies in Systemic Autoimmune Diseases - A Diagnostic Reference
Testing for autoantibodies can be helpful or necessary for the diagnosis, differential diagnosis, prognostication, or monitoring of autoimmune diseases. The diagnostic sensitivity and specificity, the positive and negative predictive values as well as the likelyhood ratios of a given autoantibody for the corresponding disease are important criteria for evaluating its diagnostic relevance for a particular disease. The higher these parameters, the more valuable the antibody is for the corresponding diagnosis.
These parameters differ when using different tests for detection of a particular antibody. The diagnostic sensitivity is the proportion of patients with the disease who are correctly identified by the autoantibody test. The diagnostic specificity is the proportion of patients without the disease who are correctly identified by the autoantibody test. Ideally, the diagnostic sensitivity and specifity must both be 100%; however, none of the diagnostically relevant autoantibodies achieve this goal. The use of highly sensitive enzyme immunoassays increases the diagnostic sensitivity, but usually does so at the expense of diagnostic specificity ...
>> . Pabst, 360 pages.Karsten Conrad, Werner Schößler, Falk Hiepe, Marvin J. Fritzler: Autoantibodies in Systemic Autoimmune Diseases - A Diagnostic Reference
ISBN print 978-3-89967-883-3: http://www.pabst-science-publishers.com/index.php?30&backPID=30&swords=978-3-89967-883-3&tt_products=179K.
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