Press release
RNA-Based Therapeutic Market: Unveiling the Remarkable Compound Annual Growth Rate (17.6 % CAGR) - 2023 To 2030
RNA therapy is a term used to describe the use of RNA-based molecules to modulate biological pathways to cure a specific condition. In general, the RNA sequence is the key to manipulating the expression or activity of its target molecules.
According to the report, the global RNA based therapeutics industry was estimated at $4.93 billion in 2021, and is anticipated to hit $25.12 billion by 2030, registering a CAGR of 17.6% from 2021 to 2030.
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Impact of COVID-19 on RNA Based Therapeutics Market-
There was a steep decline in the number of patients visiting clinics and hospitals for RNA based therapies, which, in turn, decreased the demand for RNA based therapeutic products, especially during the initial phase of the pandemic. This impacted the global RNA based therapeutic market negatively.
Also, mRNA vaccines could potentially offer long-term solutions all over the world for diseases ranging from influenza to AIDS, but owing to lockdown measures and temporary closure of research institutes and academic research, the demand for RNA based therapeutic solutions decreased significantly.
This trend is quite likely to continue till the pandemic is completely over.
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Key Takeaways:
mRNA Vaccines' Success: One of the most notable developments was the success of mRNA vaccines, particularly the Pfizer-BioNTech and Moderna COVID-19 vaccines. These vaccines demonstrated the feasibility and effectiveness of using mRNA to instruct cells to produce a viral protein, triggering an immune response. This success spurred further interest and investment in mRNA technology for other diseases.
RNA Interference (RNAi) Therapeutics: RNAi technology involves using small RNA molecules to silence or downregulate the expression of specific genes. This approach showed promise in treating genetic disorders, certain types of cancers, and viral infections by targeting the underlying genetic cause.
Delivery Challenges: A significant challenge in RNA-based therapeutics was delivering the RNA molecules to the appropriate cells and tissues without triggering an immune response or causing toxicity. Researchers were working on developing effective delivery methods to ensure that the therapeutic RNA reaches its intended target.
Expanding Therapeutic Applications: Researchers were exploring the application of RNA-based therapies in various medical fields, including oncology, rare genetic disorders, neurodegenerative diseases, and infectious diseases. The versatility of RNA-based therapeutics made them a potential treatment option for a wide range of conditions.
Investment and Partnerships: The success of mRNA vaccines led to increased investments from pharmaceutical companies, biotechnology firms, and research institutions in developing RNA-based therapeutics. Partnerships between academic institutions, startups, and established companies were formed to accelerate research and development efforts.
Market Segmentation:
Technology Type:
mRNA Therapeutics: This includes mRNA vaccines, which instruct cells to produce a protein to trigger an immune response, as well as mRNA therapies for other diseases, where the mRNA is designed to produce a therapeutic protein.
RNA Interference (RNAi) Therapeutics: This segment includes therapies that use small RNA molecules to silence or downregulate specific target genes, addressing genetic disorders, cancers, and other diseases.
Application:
Vaccines: This category covers mRNA-based vaccines for various infectious diseases, including the COVID-19 vaccines, and potentially vaccines for other diseases.
Oncology: RNA-based therapies designed to target specific genes implicated in cancer growth and progression.
Genetic Disorders: Therapies targeting genetic mutations responsible for rare genetic diseases.
Neurological Disorders: RNA-based therapies aimed at treating neurodegenerative disorders by targeting disease-associated genes.
Infectious Diseases: Beyond vaccines, RNA-based therapies designed to combat viral infections directly.
Metabolic Disorders: Treating disorders caused by metabolic dysregulation using RNA-based approaches.
Delivery Method:
Lipid Nanoparticles (LNPs): The delivery system used in many mRNA-based therapies, including vaccines.
Polymeric Nanoparticles: Alternative nanoparticle-based delivery systems for RNA-based therapeutics.
Viral Vectors: Delivery using modified viruses as carriers for therapeutic RNA.
Stage of Development:
Preclinical: Therapies that are still in the laboratory testing and development phase.
Clinical Trials: Therapies that are being tested in human clinical trials, categorized by phase (Phase 1, 2, or 3).
Approved: Therapies that have received regulatory approval for marketing and use.
Geography:
Regional Markets: Separating the market by regions, such as North America, Europe, Asia-Pacific, and rest of the world, to understand regional variations in adoption and development.
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Key players in the industry-
Silence Therapeutics plc.
Arbutus Biopharma Corporation
Ionis Pharmaceuticals
Sarepta Therapeutics
Alnylam Pharmaceuticals, Inc.
Benitec Biopharma Inc.
Genzyme (Sanofi), Arrowhead Pharmaceuticals
Biogen, Inc.
Gradalis, Inc.
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