United Kingdom Hypophosphatasia Therapeutics Market 2023 : Projected to Deliver Greater Revenues during the Forecast Period 2028

Report Overview

The UK Hypophosphatasia (HPP) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Hypophosphatasia (HPP) is also known as Rathbun disease is an ultra-rare metabolic genetic disorder characterized by the abnormal development of bones and teeth due to defective mineralization, a process by which bones and teeth use minerals such as calcium and phosphorus. It caused by mutations in the tissue nonspecific alkaline phosphatase (TNSALP) gene, also called the ALPL gene. Such mutations lead to low activity of this enzyme that should be breaking down a chemical called inorganic pyrophosphate that blocks mineralization, profound muscle weakness, seizures, respiratory failure, and premature death.

According to a report, the disease is more common in older children and adults, affecting 1 per 6,370 of the population. HPP affects males and females in equal numbers. Juvenile and adult-onset forms of HPP have much lower mortality rates than those appearing in infancy, where 100% of those diagnosed in the first six months of their lives die before they reach one year. The total cost per person per year of treatment is a whopping 366,912 (assuming an average weight of 19.3 kg and 100% adherence). It seems to be rare in individuals with black ancestry.

Market Growth Drivers

The HPP community is helping to bring programs that will bring new and treatment options to people with rare diseases. Currently, clinical trials are conducted, wherein a large number of organizations are actively participating in several research programs to develop novel therapies for infantile and juvenile-onset hypophosphatasia treatment.

Introduction of several novel therapies, breakthrough therapy designation, orphan drug designation for rare diseases, financial incentives and grants by the government, clinical

studies on the safety and efficacy of products are expected to be the biggest hit in the UK infantile and juvenile-onset hypophosphatasia market over the forecast period.

Market Restraints

Gaps in making hypophosphatasia (HPP) health priority, patients non-adherence to therapy regime, high therapy cost, a smaller number of approved therapies, failure in a clinical trial at the late phase are some of the factors restraining the infantile and juvenile-onset hypophosphatasia treatment market.

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Top Major Players

The major key players operating in United Kingdom Hypophosphatasia (HPP) treatment markets are Alexion Pharmaceuticals Inc., and AM-Pharma BV primarily. There is currently no permanent solution for hypophosphatasia. Medical management is aimed at monitoring and alleviating symptoms and decreasing morbidity. Vitamin B6 may also be given to reduce seizures. On the other hand, asfotase alfa by Alexion Pharmaceuticals Inc. and recombinant human alkaline phosphatase by AM-Pharma BV considered as an effective enzyme replacement therapy to treat all forms of hypophosphatasia, prevailing in the UK market and expected to develop novel therapies for infantile and juvenile-onset hypophosphatasia treatment during the forecast period.

The report delivers the challenges in front of the United Kingdom Hypophosphatasia Therapeutics Market 2023 that allows a better understanding of the market providing a helpful comprehensive evaluation and clear-cut dynamics associated with this market. The analyst has studied the current market scenario while concentrating on the new business objectives with the lucrative opportunities that are available. This report includes changes in customer requirements, customer preferences, and the vendor landscape in the industry with key factors that are expected to influence the overall dynamics of the United Kingdom Hypophosphatasia Therapeuticss Market including the current trends, growth opportunities, restraints, and market drivers.

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Market Segmentation

By Type:

Based on type, the hypophosphatasia treatment market can be segmented into

Odonto-hypophosphatasia
Pseudo-hypophosphatasia
Others

The odonto-hypophosphatasia segment accounted for the highest share of the hypophosphatasia treatment market in 2020. This segment is expected to dominate the hypophosphatasia treatment market during the forecast period due to the high number of patients with odonto-hypophosphatasia, which is characterized by loss of premature teeth in childhood or loss of teeth in adulthood.

By Treatment:

On the basis of treatment, the hypophosphatasia treatment market can be divided into

Strensiq (asfotase alfa
Non-steroidal anti-inflammatory drugs (NSAIDs)
Thiazide diuretics
Surgery
Others

The medications generated the highest revenue in 2020 and are anticipated to witness growth during the forecast period. This can be attributed to the launch of products for the treatment of hypophosphatasia from major manufacturers. In the UK, the European Medicines Agency (EUA) also approved Strensiq (asfotase alfa) as the first approved medical treatment for infantile, perinatal, and juvenile-onset HPP.

By Route of Administration:

Based on the route of administration, the hypophosphatasia treatment of the market can be segmented into

Oral
Injectables
Others

The injectables witness huge market growth potential during the forecast period. As asfotase alfa and recombinant human alkaline phosphatase is given as an enzyme replacement therapy by the subcutaneous route of administration that targets the underlying cause of the disease.

By Distribution Channels:

In terms of distribution channels, the hypophosphatasia treatment market can be divided into

Hospital pharmacies
Retail pharmacies
Online pharmacies

The hospital pharmacies segment generated the highest revenue in 2020 and is anticipated to witness growth during the forecast period due to most of the major products are prescription products, which are available in hospital pharmacies.

By End Users:

As per the end-user, the hypophosphatasia treatment market has been segmented into

Academic and research organizations
Diagnostic centers
Hospitals and clinics

Currently, there are around 250+ hospital admissions for hypophosphatasia in the UK. Thus, the hospitals and clinics segment commands the largest market share in terms of value during the forecast period.

Top Major Players

The major key players operating in United Kingdom Hypophosphatasia (HPP) treatment markets are Alexion Pharmaceuticals Inc., and AM-Pharma BV primarily. There is currently no permanent solution for hypophosphatasia. Medical management is aimed at monitoring and alleviating symptoms and decreasing morbidity. Vitamin B6 may also be given to reduce seizures. On the other hand, asfotase alfa by Alexion Pharmaceuticals Inc. and recombinant human alkaline phosphatase by AM-Pharma BV considered as an effective enzyme replacement therapy to treat all forms of hypophosphatasia, prevailing in the UK market and expected to develop novel therapies for infantile and juvenile-onset hypophosphatasia treatment during the forecast period.

The United Kingdom Hypophosphatasia Therapeutics Market report is an easy-to-understand document giving section-wise details about the global market. Starting with the brief outline of the overall market, it will put forth the all-inclusive evaluated market statistics and different parameters for the forecast period. The report covers numerous aspects of the United Kingdom Hypophosphatasia Therapeutics market divided into product kind, application, and end-use, offering the report to assist the customers in improving their ability to make precise decisions related to the business under the United Kingdom Hypophosphatasia Therapeutics Market.

International Market Players will use the correct market facts and figures and applied math studies provided within the report back to perceive this and future growth of the worldwide Electrophoretic United Kingdom Hypophosphatasia Therapeutics market. Each section of the research study is specially prepared to explore key aspects of the global United Kingdom Hypophosphatasia Therapeutics Market. Buyers of the report will have access to accurate PESTLE, SWOT, and other types of analysis on the global United Kingdom Hypophosphatasia Therapeutics market. Moreover, it offers highly accurate estimations on the CAGR, market share, and market size of key regions and countries.

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Strategic Points Covered in Table of Content of Global United Kingdom Hypophosphatasia Therapeutics Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the United Kingdom Hypophosphatasia Therapeutics market
Chapter 2: Exclusive Summary - the basic information of the United Kingdom Hypophosphatasia Therapeutics Market.
Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges & Opportunities of the United Kingdom Hypophosphatasia Therapeutics
Chapter 4: Presenting the United Kingdom Hypophosphatasia Therapeutics Market Factor Analysis, Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.
Chapter 5: Displaying the by Type, End User and Region/Country
Chapter 6: Evaluating the leading manufacturers of the United Kingdom Hypophosphatasia Therapeutics market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile
Chapter 7: To evaluate the market by segments, by countries and by Manufacturers/Company with revenue share and sales by key countries in these various regions
Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

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